...Basic Pharmacology is a senior level/graduate level course which will make use of representative groups of pharmacologic agents to introduce the basic principles of pharmacology. Pharmacodynamics and pharmacokinetics will be the main focus of course, but concepts of cell biology, anatomy, physiology and pathology will be incorporated to present a thorough understanding of the action of drugs in the human body. The course will not cover all the major drug groups, however. The course will require study and mastery of assigned topics and chapters, and so the textbook is necessary. More importantly, the main educational goal of the class is to develop competencies deemed essential in the field of biomedicine, as reported by the AAMC-HHMI special committee. The course will require that students work through the Blackboard resources of the UM-Flint website. Students are responsible for gaining access to the Internet as needed. It is highly suggested that students avail of the resources of the UM Flint library and computer labs as much as possible. Course Objectives 1. To know basic pharmacologic terms and definitions 2. To understand concepts specific to pharmacology 3. To apply these basic concepts to the use of commonly known drugs 4. To analyze the relationship of drug action to physiologic signs and symptoms Textbook (Required) Brody’s Human Pharmacology (Molecular to Clinical) 5th Edition, by Lynn Wecker with Lynn Crespo, George Dunaway, Carl Faingold and Stephanie...
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...NEW DRUG REVIEW PROCESS Abstract Investigational New Drug (IND) review process begins from the time the sponsor files investigation new drug application and the purpose of the review is to confirm the safety and efficacy of the patient for the drug. Moreover in the process of review if the review committee notifies any deficiencies by the new drug then there will be a clinical however if there are no deficiencies the drug will be approved for new drug application and will be under continuous review to make sure , that the drug does not cause any potential harm. This entire step wise process of review is explained in the following paper INVESTIGATIONAL NEW DRUG REVIEW PROCESS The following flow chart gives an overview of the IND review process Applicant (Drug Sponsor) IND Review by CDER Statistical Pharmacology/ Toxicology Medical Chemistry Sponsor Submits New Data Safety Review Safety acceptable for study to proceed Clinical Hold Decision Notify Sponsor Complete reviews Reviews Complete and Acceptable? Sponsor Notified of Deficiencies No Deficiencies Study Ongoing INVESTIGATIONAL NEW DRUG REVIEW PROCESS I. Applicant (Drug sponsor): An applicant or the sponsor is a person or a group who takes responsibility and initiates for the investigation of new drug. A person other than an individual that uses one or more of its own employees to conduct an investigation that it has initiated is...
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...Higher Secondary Certificate (H.S.C) Institution : Ullapara Science College, Sirajganj Group : Science Passing Year : 2010 Board : Rajshahi Result : GPA: 4.80 out of 5.00 Secondary School Certificate (S.S.C) Institution : Momena Ali Biggan School, Sirajganj Group : Science Passing Year : 2008 Board : Rajshahi Result : GPA: 5.00 out of 5.00 Training Program and Seminar Attended: • Attended in day long workshop on “Pharmaceutical Marketing” arranged by the Department of Pharmacy, NUB and four esteemed national Bangladeshi Pharmaceuticals Companies. Date: 17th April, 2015. • Attended in day long workshop on “Cardiovascular Safety Pharmacology and Its Strategic Direction” arranged by the Department of Pharmacy, NUB. Date: 23rd June, 2015. • Attended in day long workshop on “Approaches to Pharma-Sector Versatility” arranged by the Department of Pharmacy, NUB and three esteemed national Bangladeshi Pharmaceuticals Companies. Date: 11th February,2016 • Navana pharmaceuticals Ltd. Visited Industries: • The SQUARE pharmaceutical Ltd., Kaliakoir, Gazipur, Bangladesh. Date:18th August,2015 • Truthfulness, Punctual • Quick learner, polite and a great team player • Hard working,...
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...Article Rebuttal Paper Carrington Ethridge 4/14/2014 Dr. Linda Vallejo Should Marijuana Be a Medical Option? In 1972, the US Congress placed marijuana in Schedule I of the Controlled Substances Act because they considered it to have "no accepted medical use." Since then, 21 US states Nations Capitol have legalized the medical use of marijuana. Supporters of medical marijuana argue that it can be a safe and effective alternative treatment for the symptoms of cancer, AIDS, multiple sclerosis, pain, glaucoma, epilepsy, and other conditions. There are multiple studies from credible sources from prominent medical organizations, major government reports, and the use of marijuana as medicine throughout world history that support this. Non-Supporters of medical marijuana like the FDA argue that it is too dangerous to use as an alternative treatment for various reasons. One example would be that legal drugs make marijuana use redundant. They also say marijuana is addictive, a gate way to use other illegal drugs, interferes with fertility, and other physical and mental illnesses. They say that medical marijuana is used as front for the legalization of a banned substance. I believe medical marijuana should be legalized in all 50 states for alternative treatment. I feel if there is more supportive evidence supporting my beliefs on this topic then there is unsupportive evidence. Plus with man-made drugs they usually have a lot...
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...Medication Administration Errors A medication error is commonly defined as a deviation from the physician’s medication order in the patient record or an error occurring in the medication-use process. (Choo, Hutchinson, & Bucknall, 2010, p. 854) The review of literature in the article “Nurses’ Role in Medication Safety” attempts to identify the challenges of medication safe delivery in the clinical practice by reviewing multiple studies. The article authors define two different approaches to viewing human errors in medication errors. The “person” approach focuses on the individual nurse making the error and focuses on the unsafe behavior related to inattention, forgetfulness, carelessness, negligence or recklessness. With this approach, errors are reduced by modifying human behavior. The system approach focuses on the working conditions and looks at errors as results of systems problems within the clinical setting, such as staff shortage, increased workload, interruptions etc. (Choo, Hutchinson, & Bucknall, 2010, p. 855) The system approach is more conducive to changing processes which contribute to errors instead of blaming the individual. Work environments are reported as being a major influence in medication errors. The authors cite a study by Sanghera et al. (2007) which states lighting, nurse interruptions, and poor communication amongst team members contribute to medication errors. Another study is cited as reporting increased workload for nurses as another cause of medication...
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...Funmi Ajakaiye Application Paper 2 Pain Medication Pain is an unpleasant feeling which signals to an injury. Pain can be of different forms. It can be acute or chronic pain. Each and every person has a different tolerance level towards pain. It can be treated in different ways, but the relief from the pain differs from person to person. There are different kinds of medications that a person can take, which includes prescription or non-prescription medications. All medications regardless of what they are or what they do should be taken with caution. Non-prescription medications include “Nonsteroidal anti-inflammatory drugs (NSAIDs), including Tylenol, Excedrin, Ibuprofen, Motrin, Aleve, Advil, etc. Then you have prescription medications which are Corticosteroids, Opioids, Antidepressants, Anticonvulsants (anti-seizure medications) and many others”. These can be used to get rid of the common headache, arthritis, or muscle and joint pain. In some cases it may take weeks before a specific medication starts to work, therefore making a person turn to another option (WebMD, 2008). Morphine is a narcotic pain drug indicated for the relief of pain in patients who require opioid analgesics for more than a few days. Morphine interacts predominantly with the opioid mu-receptor. “These mu-binding sites are discretely distributed in the human brain, with high densities in the posterior amygdala, hypothalamus, thalamus, nucleus caudatus, putamen, and certain cortical areas. They...
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... anxiety/depression, stomach pain, headache/migraine, insomnia, and recurring pain. Among the most commonly used alternative medicines are fish oil/omega 3, glucosamine, Echinacea, Ginkgo Biloba, and Flaxseed Oil. This research paper will focus primarily on the herbal/dietary supplement St. John’s wort, which is commonly used to treat depression. Depression is a commonly treated disorder within the United States that has an estimated prevalence of 17% and is often complex in its diagnosis and treatment approaches (Linde, Ramirez, Mulrow et al., 1996). St. John’s wort has also been used for other ailments such as sleep disorders, healing cuts, and hemorrhoids. It commonly used to treat depression in Germany and Europe and is increasing in popularity within the United States. According to Gaster and Holroyd, between 1995 and 1997 the sales of St. John’s wort went from $20 million to $200 million (2000). Regardless of its historical and widespread use to treat depression, meta-analysis have revealed that St. John’s wort’s benefits are minimal when compared to placebos. St. John wort contains many active ingredients including, but not limited to: cyclopseudohypericin, hypericin, hyperforcin, isohypericin, protohypericin, and pseudohypericin (Pharmacology Weekly, 2008). Many of the ingredients have been directly associated to antidepressant effects. The supplement works through many mechanisms throughout the brain displayed in Figure 2. The supplement inhibits the uptake of serotonin...
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...NUR 641E Complete Class Click Link Below To Buy: http://hwcampus.com/shop/nur-641e-complete-class/ Advanced Pathophysiology and Pharmacology for Nurse Educators Discussion Questions week 1-8 Week 1: Question 1= Find an article on a genetic disorder and summarize in two or three paragraphs the genetic component causing the disorder and any multifactorial inheritance components that may contribute to the disorder. Discuss the usual age of disease onset and if the sex-specific threshold model fits the disorder. What education could you present to high-risk patients to reduce the risk of disease onset if a multifactorial component exists? Question 2= Genetic screening has become widely available to the public including prenatal screening of the fetus in utero to screening adults for genetic disorders, such as Parkinson's disease and breast cancer. Share your thoughts on the legal, ethical, and social implications that may be related to genetic screening. How would you educate your patient that is considering having genetic screening? Week 2: Question 1= Choose an FDA-approved prescription medication and discuss the pharmacokinetics and pharmacodynamics of the medication, including any differences that would be expected based on the patient's age, a condition of pregnancy, or lactation. Address any adverse effects the medication may have based on age, pregnancy, or lactation. Question 2= Active acquired immunity can be achieved through the...
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...The research conducted in this study focuses on how medication errors and how they are caused by doctors not being educated and trained in medical colleges about the administration and prescribing of medicine. The other problem shown in this article is that colleges within the United Kingdom are showing a lack of these special educational studies in medicine. The problem of the study is very important to Administrators because patient safety is one of the main priorities in any health care facility. Administrator overlook the progression of patient care and by seeing this study about medication errors, this should grab their attention. By knowing that doctors are not properly prescribing medications to patients, administration can take a deeper look into their faculties and makes sure all professional health care providers are up to date and fully trained in the process of prescribing medicine. The purpose of this study is to bring strong insight in the reader. Also, readers must realize that medication error dangerous and that they can happen anywhere. Not all doctors have the full education they need in prescribing medication to them. The research deals mostly on the research of the lack of education and training in medical colleges and how it influences poor medication errors. After reviewing the study, the main research question would be what causes medication errors and how can it be fixed? There are more than one hypotheses of this study. After reviewing the possible...
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...New Pharmaceuticals Josue Ortiz Institution New Pharmaceuticals Introduction Drug development process is a lengthy and costly process which can be terminated at any time during the development process. Several reasons can contribute to abandoning the drug; some of them are the presence of dangerous compounds or the irrevelance of the drug to the intended users. The process of delivering the drug into the market takes considerable time, and it can take more than a decade. This paper will discuss the process of delivering a new drug into the market and will give an example of a new drug that has been approved. New Drug Development Process New drug development process has three major steps that cost the company over $500 million. The first step starts with preclinical studies. At this stage, new drug is tested on animals with the primary aim of examining its pharmacological and therapeutic compounds as well biologically dangerous compounds. The second step is the Investigational New Drug Application (IND). At this stage, the drug is submitted to the Food and Drug Administration (FDA) for approval before testing it on humans. The company is expected to give details with regard to compound composition, protocols that will be applied in Phase 1 and the clinical research plan. More than 5000 compounds are submitted for clinical testing but only one of them is approved for marketing (Sharp, 2001)...
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...related by their chemical structure, the way they work or if they are used for the same purpose (Pubmed Health, 2012). A cholinergic stimulant is a class of drugs used to increase activity at acetylcholine synapses and can be further subdivided into two categories; direct and indirect acting cholinergic stimulants. This categorization is based on their mechanisms of action and specificity for clinical use (Ciccone, 2007). Direct-acting cholinergic stimulants increase activity at the acetylcholine synapses by binding directly with the cholinergic receptor on the other hand; indirect-acting cholinergic stimulants put forth the same effect by inhibiting the acetylcholinesterase enzyme situated on the cholinergic synapse. For the purpose of this paper, an analysis of indirect acting cholinergic stimulants will be completed, with focus on Pyridosigmine and Prostigmin and their implications to physical therapy practice. Indirect-Acting Cholinergic Stimulants Indirect-acting cholinergic stimulants are also known as Cholinesterase inhibitors or Anticholinesterase agents. Cholinesterase inhibitors increase activity at cholinergic synapses by preventing the acetylcholinesterase enzyme from breaking down acetylcholine (ACh) after its release from the presynaptic terminal. Cholinesterase inhibitors inhibit acetylcholinesterase thus allowing more acetylcholine to remain at the synapse which results in an increase in cholinergic synaptic transmission (Ciccone, 2007). For circumstances where acetylcholine...
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...Pharmacology In this paper the author will discuss the effects of different substances of abuse on the user’s body, depending on the method of administration and different pharmacological principles that are in effect. (Doweiko, 2015). Effects of Drugs of Abuse All chemicals or pharmaceutical agents have a biological impact on the body. They all change “the biological function of target cells through chemical actions” (Doweiko, 2015, p. 16). In cases of drugs of abuse the target is most often the central nervous system. There is always a primary effect or the desired effect and then there is also the side effects and usually undesired effect. Some side effects are minor while others can be fatal (Doweiko, 2015) Drugs classifications can be categorized in a couple of different ways for different applications. In the medical world a drug can be classified by its chemical activity or by the symptom it treats. In the world of addiction treatment and recovery the drug classifications most used are the five classes of drugs regulated by the Controlled Substances Act (U.S. Department of Justice, n.d.). The chemical classifications of the ones that act on the central nervous system (CNS) and alter feelings and perceptions are: narcotics, depressants, stimulants, hallucinogens and anabolic steroids. Narcotics (often referred to as opioids) reduce pain, induce a state of sedation and can cause unconsciousness. Depressants suppress the activity of the brain and nerves and...
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...Most frauds of this nature involve accounting personnel falsifying financial information with the intent of materially misstating the financial statements. Nonfinancial measures are much more difficult for accounting personnel to manipulate, especially those produced independently; therefore, auditors have increasingly used these nonfinancial measures to help them detect fraud. In order to utilize the nonfinancial information of a company for auditing purposes, auditors must select Key Performance Indicators (KPIs) for the company or industry. By compiling KPIs for a company and its competitor(s), the audit team can compare the nonfinancial measures and the effects they might have on the financial statements. The purpose of this paper is to identify three KPIs for Pfizer, Inc. and compare these measures with those of Merck & Company, Inc. Both of these companies focus mainly on the development and sale of pharmaceutical drugs. The success of companies in this industry relies greatly on research and development of new drugs. New drugs stay in the research and development phase until they are granted FDA approval. For this reason, we have selected number of FDA approvals as a KPI for Pfizer and Merck. The pharmaceutical industry is fiercely competitive. Manufacturers of drugs are constantly coming out with new drugs that compete with existing drugs on the market. This makes it very difficult for company’s drugs to maintain their market share from year to year...
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...Pharmaceutical Testing of India's People Maira Watts Tarleton State University Abstract This paper looks at the pharmaceutical medical trials and clinical drug testing on the people of India as the ethical perspective conducted from journals and articles provided along with a video that was shown to understand the perspective of what we were to analyze. The journals speak on the process of approval, laws that are in place to advocate for the people, and the overall plight of the subjects that sign up for the clinical trials. The World Health Organization (WHO) and the Drugs Controller of General India (DGCI) are the two main controlling factions in the process to monitor and regulate the companies and sponsors that conduct clinical trials in India. This paper will discuss what happens to the people in the lower caste and what can be done to improve the situation of subjects that are part of the trials. Introduction Clinical medical trials are becoming one of the most prominently profitable industries in the world to come to a country with such a large population spread as India. The country is a largely technically adept workforce that has a great amount of population that demonstrate a variety of medical conditions along with the low cost of introduction into market which makes India hotbed for these medical trials. It comes down the problems of being ethical, is it right for the people, what ill effects will it have on these people, and do they even know...
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...CHAPTER 1: Pharmacology is defined as the STUDYING OF DRUGS, THEIR USES, AND THEIR INTERACTIONS IN LIVING TISSUE The physician must have permission from the FDA to dispose of any outdated medications. FALSE What government agency or agencies control prescription or legend medications? A AND C (DRUG ENFORCEMENT AGENCY AND FDA) Drug testing is done on which of the following before being named an Investigational New Drug? ANIMALS The physician must keep which of the following records when using drugs found on the DEA list of scheduled medications? ALL OF THE ABOVE The FDA is a division of the DEPARTMENT OF HEALTH AND HUMAN SERVICES The person(s) with the responsibility for obtaining information and keeping records of all drugs used by a patient (both prescription and over-the-counter medications and herbs) is/are the A AND B (PHYSICIAN AND MEDICAL ASSISTANT) Prescription pads make wonderful notepads and paper for ordering blood tests and X-rays. FALSE OTC means OVER THE COUNTER Who dispenses medications? PHARMACISTS CHAPTER 2: Anaphylaxis is a possible allergic response with any medication and may be fatal. TRUE Which of the following are considered the major drug actions? DEPRESSION, STIMULATION, IRRITATION, DEMULCENCE The amount of drug circulating in the body is called the drug’s BLOOD LEVEL Recombinant DNA technology uses artificially manipulated DNA segments for transfer from a cell of one species to a host...
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