...Private Equity Investments - Final Exam (July/ 4/ 2011) Question 1-a a. What are financial theory and concepts that support and rationalize activities of parties involved in the events leading to the financial crisis? Why and how did the meltdown happen? Is the model used in the process wrong? Answer 1-a Moral hazard nurtured by Real estate and MBS bubble; House prices of the United States had risen steadily since 1975. This trend accelerated in 1996, and reached about 12 percent per annum in late 2005 and early 2006. One reason for the rise in house prices is the Federal Reserve’s policy of maintaining low interest rates after the 2001 recession. Under these market situation, mortgage loan and mortgage backed securities market became more popular and bigger. The financial markets’ appetite for mortgage product also resulted in more creative and complex financial products and strategies such as MBS (Mortgage-backed securities), CDO (Collateralized debt obligation), ABCP (Asset-backed commercial paper), Conduits, SIV (Structured investment vehicles). For example, according to the case, the S&L crisis also boosted the securitization of mortgages by two government-sponsored enterprises (GSEs), Fannie Mae and Freddie Mac. Starting with bundles of mortgages purchased from mortgage originators, the GSEs created and sold mortgage-backed securities (MBSs), which delivered to holders the payments made on these mortgages. In exchange for a fee, the GSEs guaranteed...
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...Province of the Eastern Cape Department of Public Works PE : Hirsch Flats : Forest Hill Military Base : Compl. Electrical Renovation Tender No : SCMU5-08/09-0443 E082/EB6.2 Inspection Schedule 27/05/15 Date Printed : Inspection Schedule Electrical Installation EB The following items were inspected on on the dates statedand were found to be unacceptable in terms of the specifications and instructions. The said items shall be remedied immediately and will be subject to further inspection. Status symbols : I = Initial record of defect; R = Repeat at subsequent inspection, remedy incomplete; P= Partial remedy as stated but incomplete; M = The effectiveness of remedy will be Monitored over time until acceptance; C = Remedy complete. Loc ID Plant Def ID Item Ref Description of defect Insp Date Stat -us Further Inspection or remedy effected 103 302.03 Flats Subdistribution Boards : DB-G01...G02, DB-101...704 : SDB 103 : Door & architrave dirty. 13/10/2014 I Remains Remains. Cleaned. Signs required. Signs fitted. Circuit breakers skew on DIN rail. CBs remain skew. No access to flat. No access to flat. Remains Remains, no access. Remains, no access. SDB 101 remains. Paintwork damage inside of SDB door frame. EB011 16/10/2014 R 27/10/2014 R 10/11/2014 R 27/11/2014 R 01/12/2014 R 08/12/2014 R 24/02/2015 R 02/03/2015 R 19/03/2015 R 02/04/2015 R 27/05/2015 ...
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...com/locate/jim Research paper CD107a as a functional marker for the identification of natural killer cell activity Galit Alter, Jessica M. Malenfant, Marcus Altfeld* Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Massachusetts, USA Received 17 June 2004; received in revised form 5 August 2004; accepted 10 August 2004 Available online 25 September 2004 Abstract Natural killer (NK) cells are a subset of lymphocytes that play a central role in the innate immune response to tumors and infections. An important limitation in the field of NK research is attributable to the deficit of assays available for the detection of the functional activity of NK cells. Recently, lysosomal-associated membrane protein-1 (LAMP-1 or CD107a) has been described as a marker of CD8+ T-cell degranulation following stimulation. Here we describe CD107a as a marker of NK cell functional activity using multi-parameter flow cytometry. CD107a is significantly upregulated on the surface of NK cells following stimulation with MHC devoid targets. Additionally, CD107a expression correlates with both cytokine secretion and NK cell-mediated lysis of target cells. However, as well as being coordinately expressed on nearly all cytokine secreting cells, CD107a was also expressed on a large subset of NK cells that did not secrete cytokine following stimulation. These data suggest that employing CD107a as a marker of NK cell functional activity may allow for the...
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...Obstetrics and Gynecology Director: Sangeeta Jain MD Coordinator: Brandie Davis Overview: The Galveston Obstetrics and Gynecology clerkship consists of 1 week Labor and Delivery Days, 1 week of Labor and Delivery Nights, I week of Antepartum, 1 week of Post-partum 1 week of Gynecology, and 1 week of Out-patient clinic. However, the structure of the course is often changed in response to student feedback, so please refer to your syllabus for details! The obstetrics portion focuses on labor and delivery, antepartum, and postpartum aspects of patient care. The weeks that you spend in gynecology vary widely and can range from community clinics to gynecologic surgery. This clerkship is highly dependent on how much effort you put into it, as evaluations from residents and faculty make up a significant portion of your grade. The clerkship is generally VERY organized, which you will learn to appreciate as you go through other clerkships. Didactics: There are lectures one day per week, which are mandatory. You will be excused from all clinical duties on your didactic day. Apart from the lectures, you will have quizzes over certain topics in Ob-Gyn (refer to syllabus for schedule). The course textbook (Beckman) is an excellent study guide for these quizzes, but make sure you have the latest edition! Other helpful study resources are the online APGO quizzes, Blue Prints, First Aid and Case Files. You are allowed to wear casual clothes on didactic days. Small Groups: ...
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...Deakin University, Faculty of Health HNM704 Clinical Challenges in Maternity Care. Due Date: 4 October 2013 Assignment 1 Wendy Taylor 212242143 1 Wendy Taylor 212242143 Pre-eclampsia is a condition in pregnancy that causes placental dysfunction and can effect multiple maternal organs, it is characterized by new onset hypertension (systolic blood pressure >140 mm Hg or diastolic blood pressure >90 mm Hg) and proteinuria (excretion of >300 mg daily) usually after 20 weeks of gestation with no history of hypertension (Wagner 2004, 3 Centre collaboration, & Stevenson & Billington 2007). Symptoms can include hypertension, proteinuria, headache, visual disturbance, epigastric pain, hyperemesis, oedema of hands and feet (Briley 2003, NICE 2008). Pre-eclampsia can affect the pregnant woman through pregnancy birth and postpartum. However the focus of this essay will discuss the possible impact on maternal and fetal health and wellbeing as well as the management of the woman and her condition during the intrapartum phase. The role of the midwife in provision of care in this case will also be explored. The woman in this case was a primigravida at 37+6 weeks gestation. On assessment at antenatal clinic it was found that her blood pressure [BP] had acutely risen to 190/110 and she had significant proteinuria, she was admitted to the labour ward for management. During labour her blood pressure fluctuated from 145/90 to 190/110, she had a severe headache, visual disturbance and was very...
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...Factors Influencing Visitor's Choices to Visit Urban Destinations Ontario Ministry of Tourism and Recreation Canadian Tourism Commission Canadian Heritage Parks Canada PREPARED BY: PREPARED FOR: Global Insight, Inc. June 2004 Table of Contents I. EXECUTIVE SUMMARY .................................................................................................. 1 Highlights................................................................................................................................ 1 Study Summary........................................................................................................................ 1 Recommendations ................................................................................................................... 2 Next Steps................................................................................................................................ 3 II. III. IV. A. INTRODUCTION............................................................................................................. 4 STUDY OBJECTIVE....................................................................................................... 4 METHODOLOGY ........................................................................................................... 5 LITERATURE REVIEW ........................................................................................................... 6 Introduction............................................
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...Five ree F e Fr Sale Trainin S es T ng Trainin Gam s T ng G mes The following g are five fre ee sales train ning activitie es we have u used for mor re than a dec cade with clien nts during our sales train ning courses s. We frequentl W ly receive requests for sa ales training g ideas from organizations wishing to develop t their own sa ales training programs. In the intere est of improv ving sales sk kills, we are sharing these activiti ies for use by others. You are welco ome to incorporate them m into your sales trainin ng courses. You may also link to them m. However, we request tha H at you not pu ublish them in a printed d guide, onlin ne guide, or otherwise wit thout our pe ermission. ities listed re equires know wledge of sa ales. While w we are happ py to answer r Each of the activi of the games s and activit ties, we requ uest that you u do your ow wn questions about the mechanics o ns related to o content. research on question For m more informa ation about onsite custo omer service e workshops s and semina ars for your group, pl lease contac ct us at: info@ @businesstr rainingwork s.com or 301‐934‐3250. . gards, Kind reg Kate Z kie Zabrisk Business T Training Works®, Inc. www.businesstrainingw works.com 1 Sale es Training Ga ames and Activities © © 2012 Table of Contents Ask or Tell? .................................................. 3 Your Order, Please ...................................... 4 Mr...
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...Abstract: Neuropathic pain is chronically increased pain and heat sensitivity resulting from damage to the central or peripheral nervous system. Neuropathic pain is constant, and difficult to treat, because the pain persists even after the injury has healed. Current drug treatments are ineffective, have short durations, and have unpleasant side effects. The SIP-30 gene is a candidate gene for involvement in neuropathic pain. When neuropathic pain is present, SIP-30 levels rise indicating some cause and effect relationship. Transposons are mobile genetic elements that move around within a genome and integrate randomly, in a mechanism similar to some viruses. The PiggyBac transposon, derived from the cabbage looper moth Trichoplusa ni, is a particularly useful transposon, with many features that make it an ideal vector for gene therapy research. Plasmid vectors will be constructed, one carrying the SIP-30 gene, and another carrying antisense SIP-30 in the PiggyBac vector, in order to deliver the genes into mouse nerve cells. This is hypothesized to increase and decrease the expression of neuropathic pain respectively. The gene will be delivered through intrathecal injections into the mouse intrathecal fluid of the spinal cord. If successful, this research can have serious implications for future human gene therapy to treat neurological disorders, using the PiggyBac vector as the gene delivery system. Introduction: Features of the PiggyBac Transposon: Transposons...
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...The Future of Cardiovascular Diagnostics THE MARKET, TRENDS & FUTURE DIRECTIONS Extracted on: 20 Apr 2011 Reference Code: BI00021-008 Publication Date: 02 Mar 2010 Publisher: Datamonitor © Datamonitor This content is a licensed product, no part of this publication shall be reproduced, sold, modified or stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of Datamonitor. The information in this document has been extracted from published research by a registered user of the Datamonitor360 platform. Datamonitor shall not be responsible for any loss of original context and for any changes made to information following its extraction. All information was current at the time of extraction although the original content may have been subsequently updated. Please refer back to the website http://360.datamonitor.com/ to view the most recent content and the original source of the information. To the maximum extent permitted by applicable law we exclude all representations, warranties and conditions relating to the facts of all publications. At time of publication no guarantee of accuracy or suitability, whether express or implied, shall attach to this publication (including, without limitation, any warranties implied by law of satisfactory quality, fitness for purpose and/or the use of reasonable care and skill). Please note that the findings, conclusions and recommendations...
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...MARKET NEWS SERVICE MNS Medicinal Plants & Extracts North America Africa Western Europe India Eastern Europe China No. 18 March 2006 This note has b een prepared, without formal editing as a service to exporters and industries in developing countries by the Market News Service (MNS), Division of Product and Market Development, International Trade Centre UNCTAD/WTO. No part of this report may be reproduced, stored in a retrieval system, or transmitted in any form or by any means without the prior permission in writing of the MNS/ITC Geneva. Copyright © MNS/ITC 2006. All rights reserved Prepared by Mr. Josef Brinckmann, ITC Consultant brink@sonic.net International Trade Centre UNCTAD/WTO 54-56 rue de Montbrillant, CH-1202 Geneva, Switzerland. Tel : (4122) 730 01 11 - Fax: (4122) 733 44 39 E-mail: itcreg@intracen.org ; URL: http://www.intracen.org Postal address: International Trade Centre UNCTAD/WTO Palais des Nations, CH-1211 Geneva 10, Switzerland 2 EDITORS NOTE MNS Medicinal Plant and Extracts report is a formatted version of a news and information bulletin prepared by the International Trade Centre to promote international trade in medicinal plants and botanical extracts. The revised version of the report includes substantially more information on the structure and function of the market. These additional features have been included after extensive consultation with existing subscribers and trade experts. For subscription details please contact MNS...
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...KDA222 AUSTRALIAN ARCHITECTURE & DESIGN / Mohamad Afiqq Che Zani @ Jailani 175756 17. Identify key urban design themes in the work of Donovan, in either residential or commercial/public buildings. This essay will explain about the key features and themes of the urban design as in BVN Donovan Hill works in their commercial/public buildings. Donovan Hill architects was established in Brisbane in 1992 by two principles, Brian Donovan and Timothy Hill are graduate of the University of Queensland. Most of their design approach practiced in Australia is influenced by United Kingdom and United States architects and theorist such as Colin Rowe, Christopher Alexander and Colin St John Wilson.1 BVN Architecture is one of Australia’s biggest architectural practices, well-known for award winning across a broad and diverse portfolio in Australia and outside Australia. “The architectural engagement ranges from civic and institutional projects to office and residential design, tourism projects, industrial developments, master planning and urban design”.2 Some of their notable projects focused in this essay is in commercial/public building which is designed based on approaching the inevitability of the environment that is addressed with comprehensive understanding of the client, needs of the people, processes and places that illustrate the realm of their culture that aligns with it’s urban design.3. “Urban design defined as planned activities and products intended at resulting from the physical...
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...Am J Stem Cell 2012;1(3):196-204 www.AJSC.us /ISSN:2160-4150/AJSC1208001 Review Article Directed differentiation of progenitor cells towards an islet-cell phenotype Arif Abed1, Charlotte Critchlow2, Peter R Flatt3, Neville H McClenaghan3, Catriona Kelly1 The Guy Hilton Research Centre, Institute for Science and Technology, Keele University, UK; 2Keele Medical School, Keele University, UK; 3Diabetes Research Group, SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, UK 1 Received August 3, 2012; Accepted November 9, 2012; Epub November 30, 2012; Published December 10, 2012 Abstract: Exogenous insulin administration and oral anti-diabetic drugs are the primary means of treating diabetes. However, tight glycaemic control, with its inherent risk of hypoglycaemia, is required to prevent the microvascular and macrovascular complications of the disease. While islet or pancreas transplantations offer a longer-term cure, their widespread application is not possible, primarily because of a lack of donor tissue, the burden of life-long immunosuppression, and eventual graft rejection. The rapid increase in the incidence of diabetes has promoted the search for alternative cell-based therapies. Here we review recent advances in the directed differentiation of both endocrine and non-endocrine progenitors towards an islet-like phenotype. Keywords: Endocrine, progenitor cells, islet cells, insulin production, diabetes mellitus The need for cell-based therapies for...
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...Quality of Red Blood Cells Isolated from Umbilical Cord Blood Stored at Room Temperature Mariia Zhurova, 1 John Akabutu, 2 and Jason Acker 3 ,* Author information ► Article notes ► Copyright and License information ► ------------------------------------------------- Abstract Red blood cells (RBCs) from cord blood contain fetal hemoglobin that is predominant in newborns and, therefore, may be more appropriate for neonatal transfusions than currently transfused adult RBCs. Post-collection, cord blood can be stored at room temperature for several days before it is processed for stem cells isolation, with little known about how these conditions affect currently discarded RBCs. The present study examined the effect of the duration cord blood spent at room temperature and other cord blood characteristics on cord RBC quality. RBCs were tested immediately after their isolation from cord blood using a broad panel of quality assays. No significant decrease in cord RBC quality was observed during the first 65 hours of storage at room temperature. The ratio of cord blood to anticoagulant was associated with RBC quality and needs to be optimized in future. This knowledge will assist in future development of cord RBC transfusion product. Go to: ------------------------------------------------- 1. Introduction Fetal and neonatal anemias are among the most serious complications of pregnancy and postnatal development. The causes of fetal anemia include immune haemolytic disease [1],...
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...Supplemental Material can be found at: http://jn.nutrition.org/content/suppl/2011/01/20/jn.110.13002 1.DC1.html The Journal of Nutrition Nutrition and Disease Algal Docosahexaenoic Acid Affects Plasma Lipoprotein Particle Size Distribution in Overweight and Obese Adults1–3 Lisa M. Neff,4 Jill Culiner,4 Susanna Cunningham-Rundles,6 Cynthia Seidman,7 Diane Meehan,7 Janet Maturi,7 Knut M. Wittkowski,5 Barbara Levine,4 and Jan L. Breslow4* 4 Laboratory of Biochemical Genetics and Metabolism and 5Research Design and Biostatistics Core, Rockefeller University, New York, NY 10065; 6Cellular Immunology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, Weill Medical College, Cornell University, New York, NY 10065; and 7Bionutrition Department, Rockefeller University Hospital, New York, NY 10065 Fish oils containing both EPA and DHA have been shown to have beneficial cardiovascular effects, but less is known about the independent effects of DHA. This study was designed to examine the effects of DHA on plasma lipid and lipoprotein concentrations and other biomarkers of cardiovascular risk in the absence of weight loss. In this randomized, controlled, double-blind trial, 36 overweight or obese adults were treated with 2 g/d of algal DHA or placebo for 4.5 mo. Markers of cardiovascular risk were assessed before and after treatment. In the DHA-supplemented group, the decrease in mean VLDL particle size (P # 0.001) and increases in mean LDL (P # 0...
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...Analysis of Financial Statements Student number: 10221450 Word count: 2993 words Excluding Bibliography Course code: B9AC106 Course title: Financial Analysis Lecturer: Mr. Enda Murphy Company: Whitbread PLC Table of Contents 1. Whitbread plc 3 Financial Ratio Comparison 6 1.1 Profitability Ratio 6 1.2 Liquidity Ratio 9 1.3 Efficiency Ratio 11 2. Intercontinental hotels group plc and Ratio Comparison with Whitbread 12 3. 10% Stake in Intercontinental Hotels Group PLC 13 Conclusion 16 Market Value and Book Value 16 Bibliography 18 Appendix 20 Appendix-1 20 Appendix-2 25 1. Whitbread plc Whitbread plc is occupied with the operation of hotels and restaurants, and cafés. The company works in two fragments: hotels...
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