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Acute Pancreatitis Research Paper

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Acute pancreatitis is a sudden and serious swelling of the pancreas. The amount of inflammation ranges from mild swelling/fluid buildup to extreme tissue death. This disease usually and equally affects middle-aged men and women; however, the percentage of African Americans with acute pancreatitis is three times higher than in Caucasians. Many factors make up the etiology of acute pancreatitis; gallbladder disease being the number one cause (most common in women) followed by chronic alcohol intake as the second most common cause (most common in men). Other causes of acute pancreatitis include vascular diseases, viral infections, abscesses, cystic fibrosis, trauma, penetrating duodenal ulcers, metabolic disorders, certain drugs, Kaposi sarcoma, …show more content…
In 20-40% of acute pancreatitis patients biliary sludge is seen which is caused by biliary stasis. Factors that injure the pancreas cause the pancreatic enzymes normally activated in the intestines to now be activated within the pancreas. This is usually caused by one of two things: either a blockage to the pancreatic duct created by gallstones or a reflux of bile acids due to a weakened sphincter. Pancreatic necrosis can be the result of an obstruction to the pancreas. Trypsin, a protein-digesting enzyme, normally activated in the intestines, can become activated in the pancreas during acute pancreatitis. This can result in pancreatic hemorrhage and autodigestion. Few risk factors are associated with acute pancreatitis. Smoking, eating a diet high in fat, alcohol consumption, gallstones and genetic factors all increase the risk of falling victim to acute pancreatitis. (Lewis, 2014; Digestive Disorders Health Center, …show more content…
Management and treatment of acute pancreatitis include pain management, NPO status while maintaining hydration via Lactated Ringers infusing at a high rate (250-500mL/hr), possible NG tube to suction, parenteral nutrition, administer albumin if shock present, IV calcium gluconate, proton pump inhibitors, insulin, and antibiotics. Medications prescribed during treatment include opiates for pain such as morphine or Dilaudid, antispasmodics such as Bentyl, carbonic anhydrase inhibitors such as Diamox, antacids and proton pump inhibitors such as Prilosec, to decrease acid secretion (Lewis,

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