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Advantages And Disadvantages Of Aspirin

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Drug NSAID Chemical Structure Rationale Mechanism of action Advantages Disadvantages
Aspirin Salicylate Widely used Irreversibly inhibits cycloxygenase activity, decreased in prostaglandin synthesis ,thromboxane A2,inhibits platelet aggregration. • Analgesic for minor aches and pains
• Antipyretic -reduce fever
• Prevention and treatment of acute coronary syndromes, acute ischemic stroke and transient ischemic episodes. (low daily dose ( 75-100 mg ) - completely block platelet TXA2 production, antiplatelet action is because aspirin is highly selective to COX-1 isoenzyme(especially in platelets))
• Used in rheumatic fever, rheumatoid and osteo - arthritis.
• Adjuvant with revascularization and stent implantation procedures. • To be maintained …show more content…
• Upper Gastrointestinal disturbances are common.
• Ulcerogenic, not to use in patients with ulcer.
• Can't be administered with uricosuric drugs, decreases the effect of probenecid and sulfinpyrazone.
• Salicylate to be monitored and stopped before surgery ( possibility of increase …show more content…
• Neonates: Contraindication: necrotizing enterocolitis, thrombocytopeia, coagulation disorders, untreated infection, impaired renal function ,active bleeding and congenital heart disease where patent ductus arteriosus is necessary.
• Tocolytic effect-- to prevent preterm labor, but toxicity of it limits the application lead to fetal morbidity.
Naproxen Propionic acids More indication Reversibly inhibit COX-1 AND COX-2 enzymes. Decrease in PG synthesis. Analgesic, antipyretic and anti-inflammatory effect • Treatment for OA, acute gout, RA ,tendonitis,bursitis,juvenile arthritis,ankylosing spondylitis and primary dymenorrhea.
• Highly protein bound and displace other protein bound drug(its effectiveness is maintained)
• Holds more FDA approved indication compared to other NSAIDS. • Highly protein bound and displace other protein bound drug(other protein bound drug effectiveness decreased)
• Contraindication :hypersensitive to naproxen and other NSAIDS.
• Contraindicated in perioperative pain in CABG

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