Alport Syndrome (AS) is an uncommon renal illness caused by alterations in type IV collagen. It was discovered in 1927 by Arthur Cecil Alport who was a physician, he identified the rare genetic illness in a British family with the syndrome. What draw his attention of the family was that the males in the family affected them more than the females of the family. The males developed progressive renal failure and deafness. Why is it that the females are less affected of the disease? Well there is a pattern, and it is called “ X-LINKED “. The usual print of the gene onto the other chromosome is relatively protects female carriers who inherit an unusual alport gene on the X chromosome. Some females may develop renal insufficiency, but they experience these symptoms later in life. Males receives one Y chromosome from his father and one X chromosome …show more content…
AS is also drawn in the kidneys and sometimes causes senseineural hearing loss and other abnormalities. Hematuria, high blood pressure, swollen; ankles, feet and legs, coughing all take place when someone has AS. Usually there no sign that AS exist, typically the first indication take place is blood in the urine (hematuria). Many people with AS will experience vision and hearing loss. Alport syndrome are more harsh in men than woman, it also progresses quicker in young males. Woman with Alport syndrome usually show no signs of the disease other than blood in the urine. In rare cases, woman with this condition may have swelling, high blood pressure and nerve deafness as a complication of pregnancy. Approximately eighty percent of young males with AS can become deaf. This often happens by the time a boy reaches his adolescent years, and deafness can be present with both ears. When young girls reach adulthood. Just about fifteen percent of men with Alport syndrome have an oddly shaped lens in the eye that may lead to