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Alzheimer's Disease

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Submitted By tutorpro87
Words 1637
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Amanda Farrington
Research paper
October 17, 2014

Despite the forgetfulness, we have of the seriousness of Alzheimer’s disease; the behind the scenes action is what we need to be taking a look at. Researcher is now choosing different routes of prevention, treatment and diagnostic studies to solve this serious illness. Which different stages of diagnosis it’s difficult to find the target of what triggers the disease. With the majority of patients being diagnosed being of the elderly stage of life, testing different options is risky because of old age. As many years and millions have gone on to find the cure to stop this tragic illness that overcomes thousands of loved ones every year, scientist have decided to step back and make a strategy. With so many failed attempts of curing this disease, they decided to find an attack approach before being diagnosed. Studies have gone into the smallest detail to find common traits that those diagnosed have. While this is an endless and tedious process, they continued. Scientist have discovered that there are ways to lower the risks of being diagnosed with the disease in the future. Although there is no cure once diagnosed, there have been studies found on how to lessen your chances of getting it. Multiple articles, including National Institute of Agings “alheimer’s prevention”, state that vitamins are always a natural and healthy route as well as anti inflammatory drugs. While a healthy diet and exercise can be effective for staying healthy and fighting against most viruses, which also plays a big part in dementia and alzheimer’s prevention as well. There are know foods that protect your memory and keep you mind sharp. A mediterranean diet is said to be one, if not the healthiest diet to go by in terms of memory consumption. Other things like red wine and tea has said to play a factor in this topic as well. Previous diagnosis of other diseases that are potentially linked to dementia and Alzheimer is a common red flag that patients and doctors are focusing on. Medicinenet.com states the top 10 signs of Alzheimer disease include memory loss, difficulty performing similar tasks, problems with language disorientation to time and place, poor or decreased judgment, problems with abstract thinking, misplacing things, changes in mood or behavior, changes in personality and loss of initiative. (Howard, pg.4). While there are many different types of prevention strategy’s, some have found to be harmful to the body. As doctors in previous years have done test on mice and animals, they are finding the test to be inaccurate because of a gene that animals do not have that humans do. This has caused the test patient numbers to lower significantly. Fortunately, there have been studies made that allow a natural and holistic path of prevention the strikes interest in more patients that the medical way because of the potential damage they can cause. Alzheimers prevention is going in many different directions.
Can Alzheimer's be averted? It's a question that continue to intrigue researchers and also fuel new research. There are no clear-cut answers but partially due to the need for more large-scale studies but promising research will be under way. The Alzheimer's Association continues to fund studies discovering the influence involving exercise, diet, sociable and mental stimulation, and other factors within the development of Alzheimer’s.
A % of people together with Alzheimer’s disease (less in comparison with 1 percent) offer an early-onset type related to genetic mutations. Individuals who have these ancestral mutations are guaranteed to develop the disease. A continuous clinical trial conducted because of the Dominantly Inherited Alzheimer Community (DIAN), is testing whether antibodies to beta-amyloid can reduce the accumulation of beta-amyloid plaque from the brains of people with such genetic mutations along with thereby reduce, postpone or prevent signs. Participants in a particular test are getting antibodies (or placebo) previous to they develop symptoms, and brain scans will monitor the advancement of beta-amyloidal plaques along with other tests.
Heart Head Connection
Several conditions are seen to increase the risk of cardiovascular disease such seeing that high blood demand, diabetes and substantial cholesterol also increase the risk associated with developing Alzheimer's. Some autopsy studies show that possibly 80 percent of people with Alzheimer's disease in addition have cardiovascular disease.
A longstanding question is the reasons some people acquire hallmark Alzheimer's plaques as well as tangles, but do not develop the signs and symptoms of Alzheimer's. Vascular disease could help researchers eventually find an answer. Some autopsy studies declare that plaques and tangles might be present in mental performance without causing signs and symptoms of cognitive decline unless mental performance also shows proof of vascular disease. More research is needed to understand the URL between vascular health insurance and Alzheimer’s. (Nehlig, 2010)
Physical exercise and diet Frequent physical exercise is often a beneficial strategy to lessen the risk regarding Alzheimer's and vascular dementia. Exercise may specifically benefit brain tissues by increasing bloodstream and oxygen flow within the brain To its known cardiovascular gains, a medically approved workout program is a valuable a part of any overall wellbeing plan. (Nehlig, 2010)
Current evidence shows that heart-healthy eating can help as well protect the brain. Heart-healthy eating involves limiting the consumption of sugar and fats and making sure you can eat plenty of fruits, vegetables, and whole grains. No one diet is better. Two diets that are studied and is advisable are the DASH (Dietary Ways to Stop Hypertension) diet as well as the Mediterranean diet. Your DASH diet emphasizes vegetables, fruits and fat-free or low-fat milk; includes whole grains, fish, poultry, beans, seed, nuts, and organic oils; and restricts sodium, sweets, sugary beverages, and red-colored meats. A Mediterranean and beyond diet includes comparatively little red various meats and emphasizes whole grains, fruits and also vegetables, fish and also shellfish, and nuts. (Lerner, 2012)
Social activities Many studies indicate of which maintaining strong cultural links and retaining mentally active even as we age might lower raise the risk of cognitive diminish and Alzheimer's. Experts are not sure about the real reason for this association. It might be due to direct mechanisms by which social and thought stimulation strengthen connections between nerve cells inside the brain.
Other Clues to Alzheimer’s Deterrence
The quest for solutions to prevent Alzheimer’s disease is part of a broad research program that may be exploring numerous possibilities. For example, scientists are taking a look at caregiver stress and physical frailty as you possibly can risk factors pertaining to Alzheimer’s disease and also MCI. Other aspects of interest include bodily hormones and immunization.
Bodily hormones
Scientists are learning hormones especially those obtained by more elderly ladies as menopausal hormone therapy for their potential ability to counteract or delay Alzheimer’s sickness and age-related cognitive decrease. Several clinical demos are testing forms of estrogen along with testosterone and additional hormones in both healthful older adults and the ones with MCI. (Lerner, 2012)
Hormones such as estrogen and progesterone include significant effects within the brain, many which could relate to helping cognitive aging and also Alzheimer’s disease. Over time, research has directed to conflicting reports as to whether menopausal hormone therapy can prevent cognitive decrease in postmenopausal ladies.
Some animal and also observational studies evaluating women who did and wouldn't take estrogen have shown that the hormone may perhaps benefits cognition. Nonetheless, clinical trials involving estrogen and progestin within older women include failed to indicate similar beneficial results. In fact, just one large study showed that prolonged treatment primary hormones increased danger of dementia within women 65 and also more elderly.
Researchers now wonder if it can be better for women to begin taking hormones nearer to menopause. NIA funded clinical trials are learning the timing involving menopausal hormone therapy on cognition along with other health factors.
Other hormones being analyzed in clinical trials with regards to effects on Alzheimer’s and also cognitive decline consist of testosterone, which has tested in old men with MCI and low degrees of the hormone; growth hormone releasing hormone (GHRH), in healthy older adults and the ones with early MCI; and also DHEA, in healthful postmenopausal women.
Immunization
The thinking behind a vaccine to counteract Alzheimer’s disease is under scrutiny also. Early vaccine scientific studies in mice had been so successful in reducing tissue of Alzheimer’s-related proteins within the brain and strengthening performance on memory space tests that researchers conducted preliminary clinical trials in mankind with Alzheimer’s sickness. These studies had to be stopped, however, simply because life-threatening brain inflammation occurred using some participants.
Scientists continue refine this method, hoping to keep the vaccine’s possible benefits while reducing unwanted effects. Several pharmaceutical firms are testing prospective vaccines for safe practices and effectiveness within clinical trials.
The NIA can also be supporting a clinical trial testing no matter if intravenous immunoglobulin (IVIg), a blood product comprising naturally occurring antibodies that may be used to take care of immune-system disorders, may perhaps improve cognition through clearing Alzheimer’s plaques from the brain.

References
Santos C, Costa J, Santos J, Vaz-Carneiro A, Lunet N. Caffeine intake and dementia: systematic review and meta-analysis. Journal of Alzheimer's Disease. 2010;20 Suppl 1:S187–204.
Nehlig A. The neuroprotective effects of cocoa flavanol and its influence on cognitive performance. British Journal of Clinical Pharmacology. July 2012;75(3)
Lerner AJ, Gustaw-Rothenberg K, Smyth S, Casadesus G. Retinoids for treatment of Alzheimer's disease.. BioFactors (Oxford, England). Mar–Apr 2012;38(2):84–9.
Loef M, von Stillfried N, Walach H. Zinc diet and Alzheimer's disease: a systematic review. Nutritional Neuroscience. 1 September 2012;
Bäckman L, Jones S, Berger AK, Laukka EJ, Small BJ. Multiple Cognitive Deficits During the Transition to Alzheimer's Disease. Journal of Internal Medicine. 2004;256(3):195–204.

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