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Amygdala

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This study hypothesized that the hippocampus, amygdala, and dorsal striatum were involved in different types of memory. The authors stated previous evidence to support their hypothesis, such as previous studies showing memory deficits from posttraining stimulations of the hippocampus, amygdala and dorsal striatum. They hypothesized that the hippocampus is involved in the acquisition of information involving relationships among stimuli and would aid in the processes of memory and identification of multiple spatial locations. The amygdala was hypothesized to be involved in memories formed from Pavlovian conditioning, which involves association of a neutral stimulus with an unconditioned stimulus and gives the same unconditioned response. Lastly …show more content…
Injections were infused using a Harvard minipump for 8 minutes and a 30-gauge cannula. 0.9% saline solution was used for the sham lesion and rats were tested one week after surgery. The lateral amygdala and dorsal striatum were lesioned using injections of N-methyl-D-asparate (NMDA). The NMDA was injected into one site on the lateral amygdala on each side. The dorsal striatum was injected bilaterally with NMDA. Injections of a phosphate buffer were used to create sham lesions. The rats were tested one week after surgery. The rats that were injected with neurotoxins were watched for seizures and were given Valium if they had a seizure. 30 %Chloral hydrate, 0.9% saline, and 10% formol-saline solution were used to deeply anesthetize the rats after completions of the testing. The brains were removed, frozen, and …show more content…
For 2 consecutive days the rats were habituated to the food pellets and the radial maze for 5 minutes each day. Next was the acquisition trials, this involved the rat being placed in the center platform of the radial arm maze and four of the eight arms were lit and no adjacent arms were lit. At the end of each lit arm was food and if the rat ate the pellet from the arm the arm was rebaited only one time. After the rat ate the second pellet in the arm, the light was turned off and there was no more food in that arm. The trial would only last for 10 minutes or until 8 pellets were collected. They recorded errors, which were entries into unlit arms, choice accuracy, and the arms the rat chose to enter. In the group with the lesion to the fornix, the rats were the lesion more quickly learned the win-stay task than the sham and control groups, which showed a significant main effect of trial and of trial with regards to choice accuracy. All groups eventually acquired the same level of performance. The group with lesions to the lateral amygdala showed no effect on learning the win-stay task and had a significant effect of trial block in regards to choice accuracy. Dorsal striatum lesion group showed impairment on acquisition of the win-stay task and a

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