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Analysis of the Concept Trust

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Non-Small-Cell Lung Cancer

Lung cancer, the most preventable cancer, it is the leading cause of cancer-related deaths in men and women in Canada. In 2008, it was estimated that there would be 23,900 new cases (12,600 men and 11,300 women) of lung cancer in Canada and that there would be 20,200 deaths (11,000 men and 9200 women) from lung cancer in Canada (Lewis, Heitkemper McLean, Dirksen Ruff, O’Brien Graber, & Bucher). Non-small-cell lung cancer (NSCLC) is a term for different types of lung cancers that have different types of cancer cells that grow and spread in their own way. NSCLC accounts for 80-85% of all lung cancer cases and includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma (Gutierrez-Cabezon & et al. 2012), which are the most common types of non-small-cell lung cancer. There are some rare types of NSCLC but the purpose of this essay is to cover the most common types of non-small-cell lung cancer.
Overview of Non-small-cell Lung Cancer Squamous cell (epidermoid) carcinoma is closely correlated to smoking and environmental carcinogens such as “asbestos, radon, nickel, iron and iron oxides, uranium, polycyclic aromatic hydrocarbons, chromates arsenic, and air pollution” (Lewis et al., 2010). The squamous cell carcinoma tends to originate in the central bronchi as an intraluminal growth and is thus more amendable to early detection through cytologic examination of sputum than other forms of lung cancer (Hannon, Pooler & Porth). The proportion of adenocarcinoma has been increasing over time, possibly due to the shift to low-tar filtered cigarettes, which are inhaled more deeply into the periphery of the lung and also contain a higher amount of nitrosourea (Gutierrez-Cabezon et al., 2012). Currently, adenocarcinoma is the most common type of lung cancer in North America. Adenocarcinoma can have their origin in either

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