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Anthrax

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Three Types of Anthrax Gastrointestinal - anthrax transmitted through ingestion. Pulmonar y- anthrax transmitted through inhalation. Cutaneous - anthrax transmitted through open wounds.  Cutaneous (Skin) Anthrax• A form of Anthrax -• 95% of all cases• Incubation: 2 to 3 days• Spores enter skin through open wound• Skin infection begins as a raised itchy bump
 10. Gastrointestinal Anthrax• Incubation: 2 to 5 days• Case fatality rate: 25 to 75%• has not been documented in U.S.• nausea, loss of appetite, vomiting, fever followed by abdominal pain and vomiting of blood
 11. Inhalational Anthrax• Incubation: 1 to 7 days• Usually Fatal• resemble a common cold – sore throat, mild fever, muscle aches and malaise• Then severe breathing problems and shock  cutaneous anthraxRaised itchy bump (resembles incest bite)1-2 days, develops into a vesicle (cyst)Develops into painless ulcer (1-3 cm diameter)Ulcer has black centerSwelling of surrounding tissues Swelling of adjacent lymph glands
 14. Gastrointestinal AnthraxInitial signs: nauseaLoss of appetiteVomiting bloodSever diarrheaLesions & soreness in throatDifficulty swallowingSwelling of neck &lymph glands50% of all patients develop meningitis
 16. Inhalation anthraxFlu/cold like symptomsCoughChest discomfortShortness of breathTiredness & muscle aches  . Cutaneous Anthrax Clinical Picture :- The lesions typically are 1–3 cm in diameter and have a characteristic central black eschar. Marked edema occurs. Lymphangitis and lymphadenopathy and systemic signs and symptoms of fever, malaise, and headache may occur.
 24. Cutaneous Anthrax Cutaneous Anthrax Vesicle Development Day 2 Day 4 Eschar Formation Day 6 Day 10 Day 7
 25. Cutaneous Anthrax Sequelae :-1) Healing After 7–10 days the eschar is fully developed. Eventually it dries, loosens, and separates. healing is by granulation and leaves a scar. It may take many weeks for the lesion to heal and the edema to subside.
 26. Cutaneous Anthrax Sequelae :-2) Death In as many as 20% of patients, cutaneous anthrax can lead to sepsis, the consequences of systemic infection (including meningitis ) and death
 27. Cutaneous Anthrax
 28. Inhalation Anthrax Preview:- Incubation period: 1-7 days (range up to 43 days). Infection occure by inhalation of B.Anthrasis spores. Case-fatality: 1) without antibiotic treatment – 85%- 97% 2) with antibiotic treatment – 75% (45% in2001)
 29. Inhalation AnthraxClinical Picture:- The early clinical manifestations are associated with marked hemorrhagic necrosis and edema of the mediastinum.
 30. Inhalation Anthrax Clinical Picture:- Rapid deterioration with fever, dyspnea, cyanosis and shock. Hemorrhagic pleural effusions follow involvement of the pleura; cough is secondary to the effects on the trachea.
 31. Inhalation Anthrax Chest X-rays isChest X-Ray :- advised as an initial method of inhalation anthrax detection, but it is sometimes not useful for patients without symptoms. Find a widened mediastinum and pleural effusion
 32. Inhalation AnthraxChest X-Ray :- Substernal pain may be prominent, and there is pronounced mediastinal widening visible on x-ray chest films
 33. Gastrointestinal anthraxPreview:-Animals acquire anthrax through ingestion of spores and spread of the organisms from the intestinal tractThis is Rare in Humans, Gastrointestinal anthrax is Extremely Uncommon.
 34. Gastrointestinal anthraxClinical Picture :-Abdominal pain, vomiting, and bloody diarrhea are clinical signs.Sepsis occurs, and there may be hematogenous spread to the gastrointestinal tract, causing bowel ulceration, or to the meninges, causing hemorrhagic meningitis. Cutaneous Anthrax
About 95 percent of anthrax infections are cutaneous anthrax. Transmission occurs when Bacillus anthracis enters a cut or abrasion on the skin, which can happen when handling contaminated wool, hides, leather, or hair products (especially goat hair) of infected animals. A cutaneous anthrax skin infection begins as a raised, itchy bump that resembles an insect bite, but within one to two days develops into a blister. This blister then turns into a painless ulcer with a characteristic black necrotic (dying) area in the center (see Anthrax Pictures). Lymph glands in the adjacent area may swell, too. About 20 percent of untreated cases of cutaneous anthrax will result in death. Deaths from this anthrax type are rare when appropriate treatment is received. Inhalation Anthrax
Inhalation anthrax is caused by breathing in the anthrax bacteria or spores. Most of the time, this occurs by breathing in spores from infected animal products. It can also occur if anthrax was used as a biological weapon. Gastrointestinal Anthrax
Gastrointestinal anthrax occurs with the consumption of contaminated meat. This anthrax type is characterized by an acute inflammation of the intestinal tract. Symptoms can include: * Nausea * Loss of appetite * Bloody diarrhea * Fever * Severe stomach pain * Vomiting blood. Gastrointestinal anthrax results in death in 25 to 60 percent of cases.

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