Free Essay

Article Review on Chronic Caffeine

In:

Submitted By dixieangelec
Words 729
Pages 3
The name of this article was “Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity”. The hypothesis of this study was that chronic caffeine intake reverses aging-induced insulin resistance in rats. The study included other aspects in order to rule these other aspects out of the cause of the insulin sensitivity. This meant that nothing else could be the cause of the insulin sensitivity. Wistar rats were used to test whether caffeine intake affected aging-induced insulin resistance. The experimental groups were three groups of rats treated with caffeine. These three groups were of different ages: 3 months, 12 months, and 24 months. The control groups were three groups of the same ages used in the experimental groups, but these were not treated with caffeine. The manipulations occurred in separating the rats into age groups and separating them into groups that get caffeine and those that do not get caffeine. Everything else in this study was constant including the amount of caffeine given and the amount of time it was administered.
This was an accurate test of the hypothesis. The hypothesis wanted to test caffeine intake and aging induced insulin resistance. This required groups of different ages to be tested. These groups also needed to each have their own control group to be able to determine any difference in what was being tested. The dependent variable was glucose disappearance and the independent variable was age and caffeine intake.
The results indicated that caffeine completely reversed the aging-induced insulin resistance in both 12 months and 24 months experimental groups. The caffeine did not affect insulin sensitivity in the 3 months group enough to be significant. Because the caffeine was only administered to the experimental groups, the control groups were not affected by the caffeine at all. The effect of caffeine on Glut4, AMPKα1, and AMPKα1 Thr172 phosphorylation expression in skeletal muscle was also tested. The Glut4 transporters decreased significantly; however, chronic caffeine intake restored Glut4 to normal levels. AMPKα1 levels were greatly decreased in 12 month and 24 month rats, but this was not caused by caffeine intake. The AMPKα1 Thr172 phosphorylation was not changed through aging or through the intake of caffeine.
The effect caffeine intake had ono cortisol, epinephrine, and norepinephrine levels was also tested. Aging increased cortisol levels as the levels in the 12 month and 24 month rats were higher. Both epinephrine and norepinephrine levels were decreased. While these changes occurred, none were caused by chronic caffeine intake.
Weight was also measured and it was found that chronic caffeine intake did not significantly modify body weight in any of the different age groups. However, the caffeine did reduce visceral fat mass in the 12 month group of rats. This meant that the results of caffeine intake increasing insulin sensitivity were not caused by weight loss or any other aspects. These results prove the hypothesis of this study.
Rats are physiologically similar to humans. Some characteristics both share are: warm-blooded, similar hormones controlling the body, nervous systems work in the same way, and react similarly to infection and injury. Therefore, this study could be used as a parallel for a study on how caffeine would affect insulin sensitivity in humans.
One thing the knowledge that this study produced changed, is the thought that caffeine causes weight loss. The article referred to the thought and that it was a widely accepted thought. While this study was not directly testing caffeine intake and weight loss, it was one of the variables that needed to be ruled out as a cause of insulin sensitivity. This indirectly stated that weight loss was not a direct result of caffeine intake.
While many people do not like rats, some even being terrified of them, rats can be very useful to the study of science and physiology. As it was already mentioned, rats and humans are similar in their physiological reactions and other aspects. This study has proven that a study can be done on rats and the results could possibly be used to explain physiological views about humans and different problems that humans face. Some issues rats are known to be studied for are high blood pressure and heart disease. Possibly, in the near future, rats can be helpful in discovering remedies for many other problems as well.

Similar Documents

Free Essay

Biostatistics Journal

...ARTICLE IN PRESS Sleep Medicine Reviews (2008) 12, 153–162 www.elsevier.com/locate/smrv CLINICAL REVIEW Caffeine: Sleep and daytime sleepiness Timothy Roehrsa,b,Ã, Thomas Rotha,b a Sleep Disorders and Research Center, Henry Ford Hospital, 2799 W Grand Blvd, CFP-3, Detroit, MI 48202, USA b Department of Psychiatry and Behavioral Neuroscience, School of Medicine, Wayne State University, Detroit, MI, USA KEYWORDS Caffeine; Daytime sleepiness; Sleep disturbance; Caffeine dependence Summary Caffeine is one of the most widely consumed psychoactive substances and it has profound effects on sleep and wake function. Laboratory studies have documented its sleep-disruptive effects. It clearly enhances alertness and performance in studies with explicit sleep deprivation, restriction, or circadian sleep schedule reversals. But, under conditions of habitual sleep the evidence indicates that caffeine, rather then enhancing performance, is merely restoring performance degraded by sleepiness. The sleepiness and degraded function may be due to basal sleep insufficiency, circadian sleep schedule reversals, rebound sleepiness, and/or a withdrawal syndrome after the acute, over-night, caffeine discontinuation typical of most studies. Studies have shown that caffeine dependence develops at relatively low daily doses and after short periods of regular daily use. Large sample and population-based studies indicate that regular daily dietary caffeine intake is associated with disturbed...

Words: 7248 - Pages: 29

Free Essay

Knowledge and Behavior Towards Caffeinated and Carbonated Beverages Among High School Students

...Knowledge and Behavior towards Caffeinated and Carbonated Beverages among High School Students Chapter One Introduction of the Study Chapter one is divided into five parts: (1) Background and Theoretical Framework of the Study, (2) Statement of the Problem and Hypothesis, (3) Significance of the Study, (4) Definition of Terms, and (5) Delimitation of the Study. Part One, Background and Theoretical Framework of the Study, presents the rationale and the reasons why the study is being conducted. Likewise, it describes the theoretical basis of the study as well as the conceptual framework. Part Two, Statement of the Problem and Hypothesis, describes the general goal of the study and the specific questions to be answered in the study with corresponding hypothesis to be tested. Part Three, Significance of the Study, enumerates the different beneficiaries and corresponding benefits that they can derive from the results of the study. Part Four, Definition of Terms, lists alphabetically technical terms used in this study. These terms are defined conceptually and operationally. Part Five, Delimitation of the Study, identifies the scopes and limitations encountered during the conduct of the study. It identifies the variables, the subjects, research designs and statistical analysis procedures used in the study. Likewise, it specifies the location and time of the conduct of the study. Background and Theoretical Framework of the Study Soft drinks and sodas could...

Words: 12041 - Pages: 49

Free Essay

Is It Possible for the Old to Resist Cola

...managers attempt to change the production method and find appropriate advertising ways to satisfy consumers’ needs (Bowles Jr et al, 1984). However, some surveys still indicate that the sale of Coca-Cola is larger than that of Pepsi Cola. The factors resulting in Pepsi Cola only in the second place in the competition are diverse, however, this article only explores whether the old group, which accounts for the majority of population, especially in developed countries, refuses this kind of soft drink or not and whether the factor of health indeed plays a crucial role in the old’ s purchase. This article has been organized in the following way. The definitions of consumer, consumer behavior together with health are explained in the first part. In the second part, an experiment is introduced about who has reading nutrition labels habit and the findings are also listed. The third and fourth parts are the extension of the second one, that is, analysis of the findings and some reasonable suggestions to the company. Therefore, the third and fourth parts are the cores of the whole article. The last part is my conclusion about the whole article. Definitions Some important factors and their effects are analyzed on the basis of explanations of their definitions. Schiffman (1995) suggested that the term, consumer was always divided into two different groups, that is, personal consumer and organizational...

Words: 2275 - Pages: 10

Premium Essay

Nur 641e Complete Class

...NUR 641E Complete Class Click Link Below To Buy: http://hwcampus.com/shop/nur-641e-complete-class/ Advanced Pathophysiology and Pharmacology for Nurse Educators Discussion Questions week 1-8 Week 1: Question 1= Find an article on a genetic disorder and summarize in two or three paragraphs the genetic component causing the disorder and any multifactorial inheritance components that may contribute to the disorder. Discuss the usual age of disease onset and if the sex-specific threshold model fits the disorder. What education could you present to high-risk patients to reduce the risk of disease onset if a multifactorial component exists? Question 2= Genetic screening has become widely available to the public including prenatal screening of the fetus in utero to screening adults for genetic disorders, such as Parkinson's disease and breast cancer. Share your thoughts on the legal, ethical, and social implications that may be related to genetic screening. How would you educate your patient that is considering having genetic screening? Week 2: Question 1= Choose an FDA-approved prescription medication and discuss the pharmacokinetics and pharmacodynamics of the medication, including any differences that would be expected based on the patient's age, a condition of pregnancy, or lactation. Address any adverse effects the medication may have based on age, pregnancy, or lactation. Question 2= Active acquired immunity can be achieved through the...

Words: 2242 - Pages: 9

Free Essay

Stress Management

...Stress is a normal physical response to events that make you feel threatened or upset your balance in some way. In other words, stress is a demand made upon the adaptive capacities of the mind and body. It is a demand upon the body’s capacity. When your capacity for handling stress is strong and healthy, the outcome is positive. When you lack the ability to handle the demands, the outcome is negative. The stress response is the body’s way of protecting you. Harvard physicians Robert Yerkes and John Dodson first described the relationship between stress and performance in 1908. The Yerkes-Dodson Principle implies that to a certain point, a specific amount of stress is healthy, useful, and even beneficial. When you are working, it helps you stay focused, energetic, and alert. In emergency situations, stress can save your life. I think stress helps us rise to meet challenges. Anxiety assumes an extremely imperative part on building fixation power. For example, it can keep you on your toes throughout a presentation at work, or drives you to study for an exam than sitting in front of the TV. Anyhow past a certain point, stress quits being useful and begins bringing on real harm to one's health, productivity, relationships, and quality of life. The signs and indications of stress over-burden might be practically anything. Stress influences the brain, body, and conduct from numerous points of view, and everybody encounters push diversely. Overwhelming stress does not only lead to...

Words: 1507 - Pages: 7

Premium Essay

Beet Athletic Performance

...significantly increased their anaerobic threshold after beet juice supplementation compared to testing without. This means increased oxygen capacity allowed them to swim longer before reaching exercise failure after drinking beet juice. The athletes were also shown to have a decreased aerobic energy cost supplementing with beet juice. A lowered energy cost enabled the swimmers to sustain an increased exercise time. The results indicate beetroot juice supplementation may enhance the athletic performance of master trained swimmers. Other Research Findings A systematic review was conducted on several articles studying the effects of beetroot juice and improved cardiorespiratory endurance in athletes. More than twenty articles were selected to be studied. The focus of the review was to determine the effects of beetroot juice alone and in combination with other supplementation on cardiorespiratory endurance in athletes. The articles covered a wide spectrum of sports and included both male and female athletes. Among the athletes indicated were kayakers, triathletes, cyclists, swimmers, runners and healthy active adults. The following results from these studies and have been summarized below: Beetroot juice supplementation appears to enhance aerobic performance in both trained male and female athletes. The volume of oxygen utilized at varying intensities was greatly improved after beet juice consumption. Kayakers supplementing with beet juice before competition showed improved oxygen capacity...

Words: 1528 - Pages: 7

Premium Essay

Marketing

... ABSTRACT: The consumption of energy drinks is rapidly increasing, as demonstrated by their large market growth. The targeted demographic group is teenagers, young adults, 18 to 34 y old; although expansion into nontraditional markets is also occurring. It is claimed that energy drinks can offer an increased energy boost related to their ingredient profile of caffeine, taurine, herbal extracts, and vitamins. Research suggests that energy drink formulations, in addition to increasing energy utilization, may also improve mood, enhance physical endurance, reduce mental fatigue, and increase reaction time. However, in most cases, the corresponding mechanisms of action are not clear. In addition, concerns have been raised over their safety and with a currently weak regulatory environment, efforts need to be made to ensure consumer safety. The objective of this article is to review the current U.S. energy drink market with emphasis on its market size, target demographic, active ingredients, potential benefits, safety, and regulations. Introduction Energy drinks refer to beverages that contain, besides calories, caffeine in combination with other presumed energy-enhancing ingredients such as taurine, herbal extracts, and B vitamins. They first appeared in Europe and Asia in the 1960s in response to consumer demand for a dietary supplement that would result in increased energy (Reissig and others 2009). In 1962, a Japanese company, Taisho Pharmaceuticals, launched Lipovitan D, one...

Words: 12218 - Pages: 49

Premium Essay

Major Health Issues in the Us Today

...Paul Dereadt January 20th, 2014 Introduction Three major health conditions that is widespread in the United States today: • Heart Disease • Kidney Disease • Cancer • Kidney disease is the 8th leading cause of death in the United States. • More than 20 million adults age 20 or older in the U.S. have kidney disease and most don't know it. • Diabetes and high blood pressure are the two leading causes of kidney disease. Kidney Disease High blood pressure, especially when left untreated, can damage kidneys and lead to chronic kidney disease. High Blood Pressure • The National Kidney Foundation (NKF) has divided chronic kidney disease into five stages to create a guideline to identify and treat each level of kidney disease. The first four stages focus on ways to preserve kidney function for as long as possible. While the final stage 5 which is kidney failure reviews treatment choices. Chronic Kidney Disease  Kidney disease is on the rise.  Affects more than 10 percent of people worldwide.  Between 2000 and 2008 Kidney Disease has double in the Unites States with people over 65 years of age.  Due to increasing rate of obesity and diabetes researchers are founding increasing kidney disease with 1 in 25 adults between the ages of 20 and 29. World Wide Killer “Cancer comes from the Greek word “karkinos”, meaning crab. This word also means any dangerous and spreading evil.” 100 diseases created by abnormal cell growth...

Words: 1305 - Pages: 6

Premium Essay

Insomnia

...INTRODUCTION You climb into bed worn out and exhausted. But the minute the lights go out, you’re wide awake, worrying. The clock ticks ahead. Your anxiety builds. You wonder how you’ll survive the next day. Sleep can often be a barometer of your overall health. In many cases, people in good health tend to sleep well, whereas those suffering from repeated sleeping problems might have an underlying medical or mental health problem, be it minor or serious. Sleeping well is essential to your physical health and emotional well-being. Unfortunately, even minimal sleep loss can take a toll on your mood, energy, efficiency, and ability to handle stress. Ignoring sleep problems and disorders can lead to poor health, accidents, impaired job performance, and relationship stress. Most of us have experienced trouble sleeping at one time or another. This is normal and usually temporary, due to stress or other outside factors. But if sleep problems are a regular occurrence and interfere with your daily life, you may be suffering from a sleep disorder. Sleep disorders cause more than just sleepiness. The lack of quality sleep can have a negative impact on your energy, emotional balance, and health. A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal. Some sleep disorders are serious enough to interfere with normal physical, mental and emotional functioning. Polysomnography is a test commonly ordered for some sleep disorders. Disruptions in sleep...

Words: 2467 - Pages: 10

Premium Essay

Sugar Addiction Research Papers

...As a result, obesity rates started to rise at an alarming rate. Ultimately our “definition of what sugar is needs to expand.” Sugar is in more than just sweets, it is in bread, pasta, cereal, tomato sauce, and salad dressings (Hungry for Change). The chronic diseases that are related to obesity are not just in the obese. 40% of these metabolic diseases also effect normal weight individuals who work out (Sugar Coated). I think there is enough information out there now to win the fight against sugar this time around. In order to successful change the “food industry needs to be a part of the solution because we want them to keep making food” (Sugar...

Words: 2293 - Pages: 10

Premium Essay

Nursing

...Before you begin your teaching plan be sure to define the characteristics of the clinical site and patient population. The teaching plan should be customized to this population. This is a sample teaching plan that you can use and customize to your needs. You may want to design a pre-test and post-test to give your patients would are attending the teaching program. Based on statistics from the Centers for Disease Control website, 17.0 million people in the United States, approximately 6.2% of the population, have diabetes. Of this 17 million people, 11.1 million are diagnosed and 5.9 million are undiagnosed. In the different age groups, about 151,000 people less than 20 years of age have diabetes, approximately 0.19% of people in this age group. In the 20 and older age group 16.9 million and 8.6% of people have diabetes. The 65 and older age group has 7.0 million and 20.1% of all people with diabetes (www.cdc.gov/diabetes). The Identified Learning Need Patients with Diabetes have very comprehensive learning needs. The learning needs are focused on managing their glucose levels and preventing complications of diabetes. Learning needs for managing diabetes are complex and include: monitoring blood glucose levels, menu/food planning, exercise, medications, skin care, management of co-existing disease processes, knowledge of medications, knowledge of the disease process and how to manage hypo/hyperglycemic episodes. Many patients are diagnosed with diabetes every year and many...

Words: 4068 - Pages: 17

Free Essay

Jhiww

...Public
Speaking
Made
Fun:
 A
Workbook
 
 
 
 
 
 
 
 
 
 
 
 
 Copyright
2011
 
 1
 Informative
Speech
–
Topic
Mapping
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 Today
I
would
like
to
talk
to
you
about
_____________________________________________.

 














 
 
 
 
 
 
 Topic
 By
examining
_______________________________

,
____________________________________
,

 
















































A


























































B
 _________________________
,
and
it
is
my
hope
that
you
will
have
a
better
understanding
 

















C













































































































































 of


_______________________________________________________.
 








































Topic
 
 



















































 






 
 
 
 
 
 
 
 
 




































2
 Learning activity created by: Todd L. Wirth, Ph.D. 3 Circle the most appropriate advice that Speech Bear should dispense based on the context clues. 1. 2. 3. 4. 5. 6. 7. 8. Advance preparation Positive thinking Practice, practice, practice Learn to use an extemporaneous style of speech Avoid chemicals as stress or anxiety relievers Use movement Seeing public speaking as a conversation, not as a performance Exercises for stress/anxiety relief 4 Circle the most appropriate advice that Speech Bear should...

Words: 10444 - Pages: 42

Premium Essay

Intervention

...performance, causing significant medical, psychological, and social disturbances.1,2 Insomnia is a widespread health complaint, and the most common of all sleep disorders.3 In the United States, the cost of insomnia, including treatment, lost productivity, and insomnia-related accidents may exceed $100 billion per year.4,5 Insomnia can be defined as the subjective complaint of impairment in the duration, depth, or restful quality of sleep. It is characterized by one or more of the following problems: difficulty falling asleep, difficulty maintaining sleep, early morning wakening, and unrefreshing sleep.6 Approximately 35 percent of the adult population have insomnia during the course of a year. Up to seven percent indicate the insomnia is chronic, severe, or both.7-9 In contrast to the occasional sleepless night experienced by most people,...

Words: 5605 - Pages: 23

Free Essay

Behavior Change Project

...Behavior Change Project The Transtheoretical Model The Transtheoretical Model (TTM) is an integrative model developed in the early 1980’s by Prochaska and DiClemente to conceptualize the process of intentional behavior change (Pro- Change Behavior Systems, 2015). The TTM emerged from a comparative analysis of the most powerful principles and processes of change from leading theories in psychotherapy and behavior change, including Conscious Raising by Sigmund Freud, Contingency Management by BF Skinner and Helping Relationships by Carl Rogers (Hayden, 2014; Hergenrather, 200*; Pro- Change Behavior Systems, 2015). Whereas other models of behavior change focus exclusively on certain dimensions of change such as social or biological, the TTM seeks to include and integrate key constructs from other theories into a comprehensive theory of change that can be applied to a variety of behaviors, populations, and settings including treatment settings, prevention and policy-making settings. Thus the name Transtheoretical (Pro- Change Behavior Systems, 2015). Stages of change It is not easy to for individuals to change from an unhealthy behavior to a healthy one. Therefore, the TTM focuses on the decision-making of the individual. It operates on the assumption that people do not change behavior quickly and decisively, rather, change in behavior, particularly long-term behavior, occurs continuously through a cyclical process (Boston University School of Public Health, 2016). The...

Words: 3063 - Pages: 13

Premium Essay

Kawasaki Disease

...Makati Medical Center - College of Nursing SY 2011 – 2012 A Case Study Presentation on the Care of a Mother with Preeclampsia Superimposed on Chronic Hypertension In Partial Fulfillment of the Course Requirement of NCM102 – Related Learning Experience Submitted To: Submitted By: Leader: Knight, Catherine P. Members: Iglesias, Pauleen Itliong, Juliane B. Javier, Reniccia Janel Joaquin, Gian Denise M. Kwek, Michael Angelo L. La Sangre, Anne Gabrielle B. Lacerna, Iruel Victor III Leynes, Sofia Antonniette M. Lindawan, Ma. Kristine S. BSN II – B Group 2 December 17, 2011 Table of Contents Chapter I - Introduction A. Description of the Case………................................................................. 4 B. Purpose and Objectives........................................................................... 5 C. Significance and Justification....................

Words: 13388 - Pages: 54