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Atrial Fibrillation Essay

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Atrial fibrillation (AF) is a heart arrhythmia that affects both the atria and the ventricles of the heart. It is characterized by an irregularly irregular heart rate. The atria are beating rapidly and irregularly, and the ventricles are beating typically fast and irregularly, but out of sync with the atria. There are several classifications for AF. Recurrent AF is defined as two or more episodes of AF. More commonly, paroxysmal AF can last up to seven days, but spontaneously resolves. If it doesn’t spontaneously resolve and persists for more than seven days it is called persistent AF. Similarly, if AF cannot be resolved in more than seven days, it is termed permanent AF. On the other hand, if AF is the only indicator of a disease associated with the heart, it is called Lone AF.
AF is the most common heart …show more content…
Reentry can maintain AF by one of two methods: fibrillatory propagation or multiple irregular reentry circuits. Both methods of reentry involve the spontaneous recirculation of conduction. The longer the conduction, the less reentry, whereas the shorter the conduction, the more reentry. A reduced refractory period will also accelerate the reentry time. Other factors influencing the reentry interval is the action potential duration, which is regulated by ion concentration. An increase of influx of Ca2+ and Na+ will prolong the action potential duration, but an outflow of K+ will shorten its duration, therefore promoting reentry.
Atrial remodeling will occur in AF electrically, structurally and neutrally. Electrically, Ca2+ entry is reduced and K+ current is enhanced. Structurally, the myocardium becomes stiff, causing fibrosis. Fibrosis separates the muscle bundles which further interfere with electric conduction of signals. Neural remodeling produces hyperinnervation of the sympathetic nervous system. The autonomic remodeling promotes the persistence and recurrence of AF via a positive-feedback

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