...DEFINATION: Nuclear receptors are a superfamily of ligand activated transcription factors that modulate specific gene expression. Currently there are 100 nuclear receptor are identified[1]. 2. INTRODUCTION: In the field of molecular biology, nuclear receptors are a class of proteins found within other molecules. In response, these receptors work in concert with other proteins to regulate the expression of specific genes thereby controlling the development, homeostasis, and metabolism of the organism. Nuclear receptors have the ability to directly bind to DNA and regulate the expression of adjacent genes, hence these receptors are classified as transcription factors. The regulation of gene expression by nuclear receptors only happens when a ligand—a molecule which affects the receptor's behavior is present. More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor which in turn activates the receptor resulting in up-regulation of gene expression. A unique property of nuclear receptors which differentiate them from other classes of receptors is their ability to directly interact with and control the expression of genomic DNA. Consequently nuclear receptors play key roles in both the embryonic development and adult homeostasis of organisms [2, 3, 4]. 3. LIGANDS: Ligands that bind to and activate nuclear receptors include lipophilic substances such as endogenous hormones, vitamins A and D, and xenobiotic endocrine disruptors...
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... Nielsen2, Jesper L. Kristensen1, Michael Gajhede1, Thomas Balle1*¤ 1 Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, 2 NeuroSearch A/S, Ballerup, Denmark Abstract Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels that belong to the Cys-loop receptor superfamily. These receptors are allosteric proteins that exist in different conformational states, including resting (closed), activated (open), and desensitized (closed) states. The acetylcholine binding protein (AChBP) is a structural homologue of the extracellular ligand-binding domain of nAChRs. In previous studies, the degree of the C-loop radial extension of AChBP has been assigned to different conformational states of nAChRs. It has been suggested that a closed C-loop is preferred for the active conformation of nAChRs in complex with agonists whereas an open C-loop reflects an antagonist-bound (closed) state. In this work, we have determined the crystal structure of AChBP from the water snail Lymnaea stagnalis (Ls) in complex with dihydro-b-erythroidine (DHbE), which is a potent competitive antagonist of nAChRs. The structure reveals that binding of DHbE to AChBP imposes closure of the C-loop as agonists, but also a shift perpendicular to previously observed C-loop movements. These observations suggest that DHbE may antagonize the receptor via a different mechanism compared to prototypical antagonists and...
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...EFSA Scientific Report (2009) 231, 1-107 SCIENTIFIC COOPERATION AND ASSISTANCE SCIENTIFIC REPORT OF EFSA Review of the potential health impact of β-casomorphins and related peptides 1 Report of the DATEX Working Group on β-casomorphins (Question N° EFSA-Q-2008-379) Issued on 29 January 2009 WORKING GROUP MEMBERS Ivano De Noni, Richard J. FitzGerald, Hannu J. T. Korhonen, Yves Le Roux, Chris T. Livesey, Inga Thorsdottir, Daniel Tomé, Renger Witkamp. 1 For citation purposes: Scientific Report of EFSA prepared by a DATEX Working Group on the potential health impact of β-casomorphins and related peptides. EFSA Scientific Report (2009) 231, 1-107 © European Food Safety Authority, 2009 Review of the potential health impact of β-casomorphins and related peptides SUMMARY Proteins are a very diverse family of large organic compounds involved in many important biological processes. Following their enzymatic hydrolysis during food processing or digestion, proteins may release fragments from their primary amino acid sequence. These fragments are called peptides, and many of them are known to be physiologically active. The possible beneficial effects of bioactive peptides have attracted increasing interest in recent years. On the other hand, there are also reports suggesting that some food-derived peptides might adversely affect human health. Among these, β-casomorphin-7 (BCM7), a peptide sequence present in the milk protein β-casein, has been suggested to...
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...caloric intake, as compared to energy consumption, combined with inadequate insulin secretion, due to dysfunction of the insulin-secreting pancreatic beta cells (Pfeiffer & Klein, 2014). Type II diabetes has reached pandemic levels, despite efforts to slow its progression. In a society where healthcare is ever-changing, primary care physicians, along with advanced practitioners are now treating this disease more readily, as compared to specialist and endocrinologist in the past. As with many disease processes, there are several options when choosing a treatment plan for type II diabetes. Combining knowledge and evidence-based research, the practitioner will be able to establish an individualized treatment plan for treating type II diabetes mellitus. Pathophysiology Type II diabetes is a very complex, non-communicable disease that effects more than 370 million people throughout the world. The symptoms of this disease can vary from patient to patient. Without intense and concentrated efforts to address the pathogenesis and treatment of this syndrome, the destructive macrovascular and microvascular outcomes of type II diabetes will remain a major problem for years to come (Kahn, Cooper, & Del Prato, 2014). In T2D plasma insulin levels may be low, normal, or high and although the specific etiology is unknown, autoimmune destruction of beta cells does not occur (Woo and Wynn, 2012). This is a distinguishing factor between type I and type II diabetes. The main physiological variation...
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...March 14, 2011 Pharmacology Dr. Hutcherson PROJECT FOR NON-CLINICAL PHARMACOLOGY STUDENT BY SUZANNE NATION PART 1: THE PATIENT’S MEDICATIONS 1. INTRODUCTION a. Mrs. Jenkins is a 73 year old Caucasian widow who lives alone and is a retired school teacher of 35 years. She is fiercely independent but is looked after by oldest daughter who comes every few days to take her to appointments and shopping for groceries. Being a former school teacher Mrs. Jenkins is well educated and knows a good deal about her medical condition and medications. She always tries to follow a strict diabetic diet and take her medications exactly as prescribed, however, when her daughter stops by to see her she is shocked to find her mother confused and having difficulty breathing. She immediately calls 911 and Mrs. Jenkins is brought to the hospital. The emergency room doctor is informed of her medical history that includes insulin dependent diabetes, congestive heart failure, hypertension, osteoarthritis, and chronic obstructive pulmonary disease. Further diagnostic testing reveals Mrs. Jenkins has pneumonia and needs to be admitted for antibiotic treatment. b. Primary diagnosis is pneumonia which is an infection of the lungs caused by bacteria, virus, and sometimes fungus, characterized by inflammation of the lungs, congestion, shortness of breath, cough and fever. Symptoms may vary. Secondary diagnoses COPD Chronic obstructive pulmonary disease which is a combination of...
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...Running Head: CASE STUDY IN INEFFECTIVE PHARMACOLOGICAL MANAGEMENT Case Study in Ineffective Pharmacological Management Southern University A&M College Graduate Nursing 652 Dr. Blair April 23rd, 2015 Introduction In the case study of Mr. J; he has been exhibiting dyspnea upon exertion and fatigue. His blood pressure was 170/95 mmHg. After reviewing his labs; his LDL level was 200 mg/dl. Upon physical examination, he was found to have peripheral edema and jugular vein distention. A chest X-ray revealed cardiomegaly and pleural effusion. An echogram has also been scheduled. Based on his signs and symptoms, the physician suspects Mr. J has new onset Stage C heart failure. Mr. J has multiple prescribed drugs for Hypertension, Hyperlipidemia, Parkinson’s, Gout and Depression. After careful reviewing Mr. J’s medications there is concerns ineffective pharmacological management. Ineffective pharmacological management refers to medication therapy prescribed that does not take into account the patient’s age, diagnoses and comorbidities; therefore leading to complications of existing health problems. Side effects, adverse reactions and drug to drug interactions have to also be considered when reviewing a patient’s medication regimen. The drug categories most commonly involved in adverse reaction are cardiovascular agents, antibiotic, diuretics, anticoagulants, hypoglycemic, steroids, opioids, anticholinergic...
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...Diarrhea / ORT DEFINITION | SIGNS/SYMPTOMS | Most commonly due to acute infectious diarrhea (gastroenteritis) from a variety of causative organismsAntibiotics are a common cause of acute diarrhea! | Acute inflammation of the lining of the stomach and intestines caused by viruses, bacteria or their toxins or parasitesPresents commonly with diarrhea, abdominal cramps, and vomiting.CommunicabilityOften fecal-oral route (especially viruses)Food poisoning (especially bacteria)Day care centers, crowded living conditions, poor sanitation and cleanliness | DIAGNOSTIC TESTS | MAIN TREATMENT | Stool gram stain and culture (if bloody stools)Stool for Ova & Parasites (if hx suggestive)CBC – assess for anemia/infectionUrinalysis and urine culture (r/o UTI)Electrolytes | Oral rehydration therapy (ORT) is one of the major worldwide health advances of the last decade:Safer, less painful, and less costly than IV rehydrationOral rehydration solution enhances and promotes reabsorption of H2O and NaReduces vomiting, diarrhea, and duration of illnessORT GuidelinesDiarrhea w/o dehydrationMild dehydrationMod dehydrationSevere dehydrationReplacing ongoing losses | MAJOR TEACHING POINTS | NURSING CONSIDERATIONS | Teach parents at well childcare visits in first yearKeep 24 hour supply of ORT in homeBegin with first sign of diarrheaReplace with ½ cup ORT for each diarrheal stoolSeek medical attention prn signs or dehydrationAfter re-hydration resume breast/formula feeding or normal diet...
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...SUBJECT REVIEW Regression Methods in the Empiric Analysis of Health Care Data GRANT H. SKREPNEK, PhD ABSTRACT OBJECTIVE: The aim of this paper is to provide health care decision makers with a conceptual foundation for regression analysis by describing the principles of correlation, regression, and residual assessment. SUMMARY: Researchers are often faced with the need to describe quantitatively the relationships between outcomes andpre d i c t o r s , with the objective of ex p l a i n i n g trends, testing hypotheses, or developing models for forecasting. Regression models are able to incorporate complex mathematical functions and operands (the variables that are manipulated) to best describe the associations between sets of variables. Unlike many other statistical techniques, regression allows for the inclusion of variables that may control for confounding phenomena or risk factors. For robust analyses to be conducted, however, the assumptions of regression must be understood and researchers must be aware of diagnostic tests and the appropriate procedures that may be used to correct for violations in model assumptions. CONCLUSION: Despite the complexities and intricacies that can exist in re gre s s i o n , this statistical technique may be applied to a wide range of studies in managed care settings. Given the increased availability of data in administrative databases, the application of these procedures to pharmacoeconomics and outc o m e s assessments may result in...
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...February 2003 SUMMARY Aim: To investigate the effects of a probiotic formulation, VSL#3, on gastrointestinal transit and symptoms of patients with Rome II irritable bowel syndrome with predominant diarrhoea. Methods: Twenty-five patients with diarrhoea-predominant irritable bowel syndrome were randomly assigned to receive VSL#3 powder (450 billion lyophilized bacteria/day) or matching placebo twice daily for 8 weeks after a 2-week run-in period. Pre- and posttreatment gastrointestinal transit measurements were performed in all patients. Patients recorded their bowel function and symptoms daily in a diary during the 10-week study, which was powered to detect a 50% change in the primary colonic transit end-point. Results: There were no significant differences in mean gastrointestinal transit measurements, bowel function scores or satisfactory global symptom relief between the two treatment groups, pre- or post-therapy. Differences in abdominal bloating scores between treatments were borderline significant (P ¼ 0.09, analysis of covariance). Further analysis revealed that abdominal bloating was reduced (P ¼ 0.046) with VSL#3 [mean post- minus pre-treatment score, ) 13.7; 95% confidence interval (CI), ) 2.5 to ) 24.9], but not with placebo (P ¼ 0.54) (mean post- minus pre-treatment score, ) 1.7; 95% CI, 7.1 to ) 10.4). With the exception of changes in abdominal bloating, VSL#3 had no effect...
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...occur intermittently and so can be difficult to diagnose. * Can present with palpitations, chest pain, presyncope/syncope, hypotension, pulmonary oedema. Some are asymptomatic e.g. AF. * History taking make sure include: * Precipitating factors, onset, nature (fast/slow, regular/irregular), duration, associated symptoms (chest pain, dyspnoea, collapse). * Causes: * CARDIAC: * MI. * CAD. * LV aneurysm. * Mitral valve disease. * Cardiomyopathy. * Pericarditis. * Myocarditis. * Aberrant conduction pathways. * NON-CARDIAC: * Caffeine. * Smoking. * Alcohol. * Pneumonia. * Drugs (β2 agonist, digoxin, L-dopa, tricyclics). * Metabolic imbalance (K, Ca, Mg, hypoxia, hypercapnia, acidosis, thyroid disease, phaeochromocytoma). * Tests: * Bloods: FBC, U&E, glucose, Ca, Mg, TSH. * ECG: look for signs of IHD, AF, short P-R interval, long QT interval, U waves. * If ECG normal consider doing 24 hour tape. * Echo: look for structural heart disease. * Others: exercise ECG, cardiac catheterisation etc. * Types of Arrhythmias: * Bradycardias: * If asymptomatic and rate >40bpm then no treatment. * Look for cause and stop any drugs that may be the cause or contributing. * If rate <40bpm and patient’s symptomatic give atropine (consider external...
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...from adrenal glands and causes vasoconstriction. - Increase all bodily activity except GIT EFFECTS OF SNS - Dilation of pupils(mydriasis) in order to be aware. - Dry mouth (thickened saliva). - Increase BP and Heart Rate. - Bronchodilation, Increase RR - Constipation. - Urinary Retention. - Increase blood supply to brain, heart and skeletal muscles. - SNS I. Adrenergic Agents - Give Epinephrine. Signs and Symptoms: - SNS Contraindication: - Contraindicated to patients suffering from COPD (Broncholitis, Bronchoectasis, Emphysema, Asthma). II. Beta-adrenergic Blocking Agents - Also called Beta-blockers. - All ending with “lol” - Propranolol, Atenelol, Metoprolol. Effects of Beta-blockers B – roncho spasm E – licits a decrease in myocardial contraction. T – reats hypertension. A – V conduction slows down. Should be given to patients with Angina Pectoris, Myocardial Infarction, Hypertension. ANTI- HYPERTENSIVE AGENTS 1. Beta-blockers – “lol” 2. Ace Inhibitors – Angiotensin, “pril” (Captopril, Enalapril) 3. Calcium Antagonist – Nifedipine (Calcibloc) In chronic cases of arrhythmia give Lidocaine(Xylocaine) Parasympathetic Nervous System (CHOLINERGIC, VAGAL, SYMPATHOLYTIC) - Involved in fight or withdrawal response. - Release of Acetylcholine. - Decreases all bodily activities except GIT. EFFECTS OF PNS - Constriction of pupils (meiosis). - Increase salivation. - Decrease BP and Heart Rate. - Bronchoconstriction, Decrease RR. -...
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...Developmental Biology 394 (2014) 242–252 Contents lists available at ScienceDirect Developmental Biology journal homepage: www.elsevier.com/locate/developmentalbiology Marker genes identify three somatic cell types in the fetal mouse ovary Raphael H. Rastetter a,1, Pascal Bernard a,1, James S. Palmer b, Anne-Amandine Chassot c,d, Huijun Chen b, Patrick S. Western e, Robert G. Ramsay f,g, Marie-Christine Chaboissier c,d, Dagmar Wilhelm a,n a Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4075, Australia c University of Nice-Sophia Antipolis, UFR Sciences, Nice, France d INSERM U1091, CNRS UMR7277, IBV, Nice, France e MIMR-PHI Institute of Medical Research, Clayton, VIC 3800, Australia f Sir Peter MacCallum, Department of Oncology and the Pathology Department, The University of Melbourne, Parkville, VIC, Australia g Department of Pathology, The University of Melbourne, Parkville, VIC, Australia b ar t ic l e i nf o a b s t r a c t Article history: Received 27 June 2014 Received in revised form 12 August 2014 Accepted 15 August 2014 Available online 23 August 2014 The two main functions of the ovary are the production of oocytes, which allows the continuation of the species, and secretion of female sex hormones, which control many aspects of female development and physiology. Normal development of...
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...NURSING CARE PLAN COURSE: Basic Adult Health CLIENT INITIALS: DATE OF ADMISSION: AGE: GENDER: JL June 13, 2011 85 M HT: WT: ALLERGIES: 140 lbs. NKA CODE STATUS: FULL RACE/ETHNICITY: CULTURAL CONSIDERATIONS: Caucasian None RELIGION/SPIRITUAL CONSIDERATIONS: Unknown OCCUPATION/HOBBIES/RECREATIONAL ACTIVITIES: Retired LIVING SITUATION/WITH WHOM: (home, assisted living, LTC, etc) Lives with daughter. SOCIAL HISTORY: (tobacco, ETOH, illicit drugs, family dynamics) Quit smoking many years ago, no history of ETOH or drug use. NURSING CARE PLAN ADMITTING MEDICAL DIAGNOSIS: Client's principal admitting diagnosis was leukocytosis. Definition: (from Taber’s) “An increase in the number of leukocytes (usually above 10,000/mm3) in the blood. It occurs most commonly in disease processes involving infection, inflammation, trauma, or stress, but it also can result from the use of some medications” (Venes, 2009, p. 1327). Etiology/pathophysiology: ( NOT from Taber’s or Wikipedia) Etiology: Causes of leukocytosis are infection, inflammation, tissue damage, immune reaction, bone marrow problems, medications, and stress (Drug Information Online, 2011). Pathophysiology: “Leukocytosis can be a reaction to various infectious, inflammatory, and, in certain instances, physiologic processes (eg, stress, exercise). This reaction is mediated by several molecules, which are released or regulated in response to stimulatory events that include growth or survival factors (eg, granulocyte...
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...Single Convention on Narcotic Drugs From Wikipedia, the free encyclopedia | [hide]This article has multiple issues. Please help improve it or discuss these issues on the talk page. | This article lends undue weight to certain ideas, incidents, or controversies. (December 2013) | This article is outdated. (December 2013) | This article needs additional citations for verification. (October 2014) | | | Single Convention on Narcotic Drugs | Governments of opium-producing Parties are required to "purchase and take physical possession of such crops as soon as possible" after harvest to prevent diversion into the illicit market. | Signed | 30 March 1961 | Location | New York City | Effective | 8 August 1975 [1] | Condition | 40 ratifications | Parties | 185[1] | Depositary | Secretary-General of the United Nations | Languages | Chinese, English, French, Russian and Spanish | Single Convention on Narcotic Drugs at Wikisource | The Single Convention on Narcotic Drugs of 1961 is an international treaty to prohibit production and supply of specific (nominally narcotic) drugs and of drugs with similar effects except under licence for specific purposes, such as medical treatment and research. As noted below, its major effects included updating the Paris Convention of 13 July 1931 to include the vast number of synthetic opioids invented in the intervening thirty years and a mechanism for more easily including new ones. From 1931 to 1961, most of the families of synthetic...
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...TOP TEN CAUSES OF POISONING Section 2-D |Roña, Diandra Krystle B. | |Rosales, Aileen L. | |Rosaura, Franz D. | |Roxas, Marie Florence S. | |Rubio, Hannah Alexis O. | |Rugay, Jesus Emmanuel R. | February 1, 2012 POISONING Poisons are substances that cause disturbances in living organisms and do so by some biologic or chemical reaction in nature. For decades, the use of different substances for various applications lead to the discovery of potential toxic substances that may have caused injurious effects. Poisoning commonly occurs thru ingestion and usually, it was unintentional. Acute toxicity is the single exposure or multiple exposures for short periods to the substance causing the injury. Symptoms may be rapid and are in close relation to the toxic agent. On the other hand, chronic toxicity are caused by repeated or multiple exposure for longer periods to the poison. Signs and symptoms of chronic toxicity may appear even after several years upon the initial exposure. ADULT TOP TEN TOXICITIES 1. CAUSTICS Caustics are strong acids and alkali that when ingested can cause tissue injury by chemical reaction. They damage the tissues by accepting a proton (alkaline substance)...
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