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Biological Causes Of Depression Essay

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It is commonly known that depression involves the interaction of both biological and psychosocial factors (Syvalahti, 1994). However, there are many characteristics of depression that cannot be explained on psychodynamic grounds- such as a decrease in weight, changes in libido and sleeping disorders (Syvalahti, 1994). A look into the biological causes of depression indicates that serotonin, a compound that acts as a neurotransmitter and regulates our emotional reactions, is a major variable in the onset of depression. Research indicates that low levels of serotonin, in relation to other neurotransmitters such as norepinephrine and dopamine (Syvalahti, 1994) is found in individuals with the disorder- for example, in the early 1960s, concentrations of serotonin metabolite were found to be abnormally low in the spinal fluid of patients suffering from depression (Syvalahti, 1994). There is increasing evidence that in patients with depression, the functioning of binding site “imipramine receptor” may be impaired (Syvalahti, 1994). The binding site of imipramine is closely related to the transport protein (re-uptake mechanism) located in serotonin neurons (Syvalahti, 1994). Changes found in imipramine binding may thus reflect disorders in serotonin transporter activity, and therefore a …show more content…
The interpersonal model of depression claims that it is the relational factors of the patient that predispose, precipitate and perpetuate the patient’s distress (Wurm, Robertson & Rushton, 2009), for example- early childhood experiences, personality factors, biology and social network. The interpersonal model holds the view that current interpersonal and social factors cause and maintain depressive

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