Necrosis

Necrosis is something that not everyone thinks they’re going to get due to it being very rare. Well you may be wondering what necrosis is. Necrosis is the disorganized breakdown of flesh in some part of the body of a multicellular organism. In an average adult human 50 billion to 70 billion cells die off and are replaced every day. Necrosis refers to cell death that is un-programmed and results from body conditions. These body conditions are things such as: Infections, cancer, serious injury, venom, severe inflammation, and the most severe being brown recluse, whose bite can cause lesions up to 10 inches. In contrast, apoptosis is a naturally occurring programmed and targeted cause of cellular death. While apoptosis often provides beneficial effects to the organism, necrosis is almost always detrimental and can be fatal. Cells that die due to necrosis do not follow the apoptotic signal transduction pathway but rather various receptors are activated that result in the loss of cell membrane integrity and an uncontrolled release of products of cell death into the intracellular space. Necrosis is irreversible and can result in gene mutation, disruption in cell membrane and organelles. Necrosis occurs when there is a shift in the structure of cells that ultimately leads to their death and hence in this situation it is difficult to ascertain the time of the death of cells. These changes in the cells occur due to multiple reasons like deprivation of oxygen, enzymatic dissolution, various type of trauma affecting cells and infections. Necrosis is serious and the lesion grows bigger as time goes on. There are different types of necrosis that occur the first being cogulative necrosis, which occurs when the structure and enzymatic protein undergoes primary denaturation. Another important necrosis is colliquative necrosis caused by a highly powerful catalytic enzyme which undergo autolysis. Necrosis is spread by the substances that kill cells are nearby other cells killing those as well. This causes an inflammation to the nearby tissue. When a large mass is affected this is called gangrene, thus the part affected has to be cut off to solve the problem. Necrosis can be very serious, especially by it being spread so rapidly. If not taken care of eventually one can die or have a large mass of the body being taken off. So taking care of the problem before it escalades is important.