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Bipolar

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The causes of this condition are contributed by genetic factors and as well as environmental influence (Kato, 2007). Study of Genetics had suggested that the regions of chromosome and the candidate genes are responsible for development of bipolar disorder. Genes of an individual are likely to effect in a small way to this disorder. Abnormalities or anomalies in the structural and functional circuits of brain could cause bipolar. Meta analyses of MRI study on structural basis of bipolar reports an increment in the volume of the globus pallidus, lateral ventricles, and in the white matter that is hyperintensities. Functional basis of MRI study shows that abnormal modulation among the ventral limbic and prefrontal regions, importantly the amygdala, contributes to mood swings and emotional regulation. Other component of brain which plays a role in this condition is the mitochondria, and the pump of sodium ATPase causing episodes of depression and mania. A study suggests that the environmental features play a wide role in the development of bipolar disorder. Evidences show that interpersonal relationships and events of life can severely affect bipolar disorder. Certain childhood events affect this condition severely. Neurological cause of this condition majorly includes stroke, brain injury, HIV infection, porphyria, multiple sclerosis, and temporal lobe epilepsy (Craddock, 2013). Dopamine which is a neurotransmitter plays role in mood swings shows a increased transmission in the manic stage. Two other neurotransmitters known as glutamate and GABA (gamma-Aminobutyric acid), causes enhanced mood states (Andreoli, 1989). External psychological and environmental factors are believed to aid in the development of bipolar disorder. Factors of such kind are known as triggers. These triggers can worsen the disorder or can increase the mania and depressive episode. Stress

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