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Blood Group Genotype Lab Report

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The molecular bases of most blood groups have been determined over the last two decades. This has been of assistance in developing of DNA based methods that are used in determining blood group genotype. Inherited blood group antigens have been described on human red cells surface. They were revealed by detecting of antigen specific anti bodies, which are mostly found in human serum. Very few of these blood group antigens are actually polymorphic in the world. This means that they have alternate alleles at great levels that can be maintained by a mutation that has to be recurrent. A few of the polymorphic antigens stimulate antibodies of clinical significance. This one happens by causing transfusion reactions or …show more content…
This is because the inactive mutations causes group O phenotype occurrence in the coding ABO gene region. The O allele is the most common allele which is distinguished from the A allele due to a G deletion at cordon 261. This leads to a creation of a frame shift .This results to a truncated enzyme. Knowledge based on the molecular bases of group O phenotype permits DNA assays, which are capable of detecting all alleles. There is a possibility of an ABO incompatible transfusion incase such methods are used for replacements of established procedures. Additional testing should be conducted to minimize risks. However, it is difficult to see or verify how DNA based methods can be used to without application of conventional serology for the confirmation of ABO type. The non-deletional alleles occur on A1 allele. Hence, any DNA method, which is not designed to select O alleles, may type the sample as …show more content…
It has an excellent product record although it does not mean it is totally risk free. Human monoclonal anti-D would avoid this risk hence introducing such a product in the market. The main problem why it is not yet introduced is the high cost. There is the use of immunodominant peptides. It is derived from the D polypeptide sequence with an aim of inducing tolerance to D antigen. Many studies suggest that it is possible. The most important valuable contribution as far as health is concerned is the diagnostic testing introduction. It is being used to determine the whether an expectant D- woman carries a negative or a positive D

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