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Cocaine Administration Research Paper

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Although there are many methods of administration for each drug, many of them fall into following these three categories: oral, injection, or inhalation. Amphetamine is usually administered through oral, insufflation, injection, or rectal. Oral administration of amphetamine is the only route used in the therapeutic setting, however is also very common as a method of recreational use. Cocaine is either snorted, swallowed, injected, or smoked. If 100 mg of cocaine is snorted, somewhere in between 15 and 30 minutes is plateau dose. Crack cocaine, which makes a crackling sound when heated, is considered to be more highly and more quickly addictive than snorted cocaine. Unlike the other stimulants with lots of methods in administration, nicotine is mainly administered by only smoking. The threshold dose of nicotine is 0.2 - 0.3 mg. In addition, since caffeine is mainly distributed through food, such as coffee and chocolates, method of administration of caffeine is usually oral. Threshold dose of caffeine is 10 - 20 mg. In addition, the effects from an oral dose of amphetamine appear within 15 to 60 minutes and peak within 2 to 3 hours. After that, the effects start to decline shortly. The second half of the amphetamine is released …show more content…
The cocaine molecule binds to the dopamine transporter molecule on the post-synaptic cleft, where the extra dopamine are taken in to be recycled. As a result, more dopamine can be used, which causes strong feelings of pleasure. Moreover, methamphetamines interfere with dopamine and norepinephrine since they have a similar chemical structure to the brain neurotransmitters. Instead of preventing the reabsorption of either dopamine or norepinephrine, they block the breakdown of these neurotransmitters, which causes pleasure, alertness and decrease fatigue. Methamphetamines also redirect where these neurotransmitters are

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