...BMC Neurology (2001) 1:3 http://www.biomedcentral.com/1471-2377/1/3 BMC Neurology (2001) 1:3 Research article Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype Address: 1L.Boltzmann Institute of Clinical Neurobiology, Baumgartner Hoehe 1, B-Bldg., A-1140 Vienna, Austria, 2Department of Neuropathology, University of Munster School of Medicine, Munster, Germany and 3Cognitive Neuropharmacology Unit, H.M. Jackson Foundation, Bethesda, Md, USA E-mail: Kurt A Jellinger* - kurt.jellinger@univie.ac.at; Werner Paulus - werner.paulus@uni-muenster.de; Christian Wrocklage - christian.wrocklage@uni-muenster.de; Irene Litvan - ilitvan@dvhip.org *Corresponding author Kurt A Jellinger*1, Werner Paulus2, Christian Wrocklage2 and Irene Litvan3 Published: 30 July 2001 BMC Neurology 2001, 1:3 This article is available from: http://www.biomedcentral.com/1471-2377/1/3 Received: 29 June 2001 Accepted: 30 July 2001 © 2001 Jellinger et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any non-commercial purpose, provided this notice is preserved along with the article's original URL. For commercial use, contact info@biomedcentral.com Abstract Background and Purpose: The impact of traumatic brain injury (TBI) on the pathogenesis of Alzheimer disease (AD) is still controversial. The aim of our retrospective autopsy study...
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...The usefulness and potential of artificial/non-caloric sweeteners as weapons to reduce or control obesity in the general population Abstract Obesity is a growing global health problem in the work. Many are increasing in weight and seeking ways to reduce weight or solution to stop matter from getting worse. Over a century ago many accidental discovery of sweetening agent which called artificial sweeteners with low or zero calories ought to be able to assist with obese and overweight issues. Many research have been done to find the actually benefit of artificial sweeteners. Sweeteners benefit from being much sweeter than normal sugar and could reach up to 600 times sweeter than sugar which industries took advantage in cutting cost of their product and heavily promote the benefit side of artificial sweeteners. Studies shows that artificial sugar does help to cut sugar calories low but on the other the population is getting more over weight on correlation with the use of artificial sugar. People tend to consume more calories from other food instead. Real sugar allows your body to accurately determine that it has received enough calories, thereby activating satiety signaling. Without the calories, your appetite is activated by the sweet taste, but as your body keeps waiting for the calories to come, sensations of hunger remain. Nonetheless many have criticized artificial sugar but it does help to reduce tooth decay and give the privilege of diabetes to satisfy the sweet tooth...
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...Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes1–3 Heike A Bischoff-Ferrari, Edward Giovannucci, Walter C Willett, Thomas Dietrich, and Bess Dawson-Hughes Downloaded from ajcn.nutrition.org at UNIVERSITY OF OTAGO SCIENCE LIBRARY on September 23, 2012 ABSTRACT Recent evidence suggests that vitamin D intakes above current recommendations may be associated with better health outcomes. However, optimal serum concentrations of 25-hydroxyvitamin D [25(OH)D] have not been defined. This review summarizes evidence from studies that evaluated thresholds for serum 25(OH)D concentrations in relation to bone mineral density (BMD), lowerextremity function, dental health, and risk of falls, fractures, and colorectal cancer. For all endpoints, the most advantageous serum concentrations of 25(OH)D begin at 75 nmol/L (30 ng/mL), and the best are between 90 and 100 nmol/L (36 – 40 ng/mL). In most persons, these concentrations could not be reached with the currently recommended intakes of 200 and 600 IU vitamin D/d for younger and older adults, respectively. A comparison of vitamin D intakes with achieved serum concentrations of 25(OH)D for the purpose of estimating optimal intakes led us to suggest that, for bone health in younger adults and all studied outcomes in older adults, an increase in the currently recommended intake of vitamin D is warranted. An intake for all adults of 1000 IU (40 g) vitamin D (cholecalciferol)/d is needed to bring vitamin...
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...Vyvanse: An Investigation of the New Breed of ADHD Treatment By Craig Leopold Psychopharmacology Dr. Zoladz 9 May 2011 On April 23, 2008, Vyvanse (lisdexamfetamine) received FDA approval for the adult population. The approval of this drug marked a new era in evolution of Attention Deficit Hyperactivity Disorder treatments. After decades of criticism on the rampant abuse and alleged overprescribing of amphetamine ADHD medications New River Pharmaceuticals responded by developing lisdexamfetamine, a compound that is inactive until converted to dextroamphetamine by the gastrointestinal tract. This means that Vyvanse is only effective when taken orally, reducing the potential for abuse. Moreover, that Vyvanse lasts much longer than typical amphetamine ADHD medications. One administration of the drug lasts throughout an entire day. Although this drug removes a few issues pertaining to amphetamine treatment of ADHD, there has been questioning as to its efficacy in treating the full range of symptoms caused by ADHD because it is broken down into dextroamphetamine alone instead of a combination of amphetamines such as Adderall. Nevertheless, Vyvanse has been established as efficacious in the treatment of ADHD symptoms. In order investigate this new breed of ADHD treatment more completely one must understand the neurobiology of ADHD, the pharmacodynamics and pharmacokinetics of lisdexamfetamine, and what the empirical evidence on Vyvanse suggests. Before...
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... [Name of Student]* A thesis submitted to the Department of [Project dept]* National University of Singapore in partial fulfilment for the Degree of Bachelor of Science with Honours in Life Sciences *Please replace with the relevant inputs. Please delete this instruction in red. Cohort AY2012/2013 S1 GUIDELINES ON THESIS WRITING ( LSM4199 (Version V) Order of presentation The order of contents should be as below: Title Page Acknowledgements Table of Contents Abstract Introduction (including Literature Review) Materials & Methods Observations and/or Results Discussion (Results and Discussion can also be combined as one section) [A short section on General Conclusion(s) can also be included] References Appendices (if there is any) Pagination All sections before the Introduction (except the Title Page) should be numbered in Roman numerals (i, ii, iii, iv, etc.) at the bottom centre of the page. All other pages should be numbered with Arabic numbers (1, 2, 3, 4, etc.) Appendices will not be paginated. Length of Thesis The maximum length of the thesis text is 15,000 words. A length of 100 pages from the Introduction to References is recommended. Please do not ‘pad’ your thesis and reach this suggestion. This is detrimental! Typing The entire thesis must be typed on white A4 paper with double...
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...determine the efficay of chlorhexidine in decontamminating the oral cavity of pathogens in mechanically ventilated intensive care patients based on published scientific literature. Significance of the Problem Pneumonia is the second most common nosocomial infection in the United States and the leading cause of death from nosocomial infections. Critically ill patients are a vulnerable population that is more susceptible to developing nosocomial infections. Ventilator-associated pneumonia (VAP) occurs in patients treated with mechanical ventilation, and is associated with a higher incidence in patients treated with continuous ventilatory support. These patients have 8% to 25% risk of developing VAP, and the risk increases by as much as 1% per ventilator day (CDC, 2015). VAP is considered a serious problem, because it extends hospital stay by 6 days or more, has substantial cost implications of up to $40,000 per patient episode, and is associated with significant morbidity and mortality rates (CDC, 2015). Strategies for the reduction and prevention of VAP are urgently needed to help reduce hospitalization costs, incidence of mortality and improve patient outcome. Evidence identifies that VAP occurs 48 hours after intubation and because length of MV increases risk of acquiring an infection, it is divided into two categories, early-onset (4 days of MV). The development of VAP linked to increased oropharyngeal colonization and bacterial...
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...or typesetting and insert your answers/corrections. ·Check that the text is complete and that all figures, tables and their legends are included. Also check the accuracy of special characters, equations, and additional files if applicable. Substantial changes in content, e.g., new results, corrected values, title and authorship are not allowed without the approval of the responsible editor. In such a case, please contact us for futher advice. · If we do not receive your corrections within 48 hours, we will send you a reminder. · The final versions of your article will be published around one week after receipt of your corrected proofs. Jaworek et al. Orphanet Journal of Rare Diseases 2012, 7:44 http://www.ojrd.com/content/7/1/44 1 2 3 4 5 6 7 RESEARCH Open Access Molecular genetic studies and delineation of the oculocutaneous albinism phenotype in the Pakistani population Thomas J Jaworek1, Tasleem Kausar2, Shannon M Bell1, Nabeela Tariq2, Muhammad Imran Maqsood2, Asma Sohail2, Muhmmmad Ali2, Furhan Iqbal2, Shafqat Rasool3, Saima Riazuddin1,4,5,6, Rehan S Shaikh2,8* and Zubair M Ahmed1,2,4,5,6,7* 8 Abstract 9 Background: Oculocutaneous albinism (OCA) is caused by a group of genetically heterogeneous inherited defects that result in the loss of pigmentation in the eyes, skin and hair. Mutations in the TYR,...
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...BUSINESS INSIGHTS The US Healthcare Market: into the 21st Century by David Sykes Projected value of the US PoM market, 1998-2007 200 180 Expenditure ($bn) 160 140 120 100 80 76 82 89 98 107 118 130 142 156 171 60 40 20 Source: Datamonitor "The vast projected increase in expenditure will offer pharmaceutical companies enormous opportunities to reap commercial reward if they are strategically placed to take advantage of these possibilities" 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 0 Business Insights Business Insights is a series of management reports designed to help you make informed, timely business decisions. We understand the problems facing today's managers in taking your business into the next millennium, and appreciate the importance of the role of accurate, up-to-date, incisive market and company analysis. We help you to crystallise your business decision making. Business Insights’ reports are authored by independent experts in their fields and offer results from our unique primary research methodology. Our authors' leading positions allow them to interview key industry executives and to quantify which issues will be of greatest strategic significance in an industry's future. The results of our analysis and recommendations will help you to evaluate the impact of these issues on your business, and plan to position yourselves to take the greatest advantage...
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...Review The Controversy about a Possible Relationship between Mobile Phone Use and Cancer Michael Kundi Institute of Environmental Health, Medical University of Vienna, Vienna, Austria oBjective: During the last decade, mobile phone use increased to almost 100% prevalence in many countries of the world. Evidence for potential health hazards accumulated in parallel by epidemiologic investigations has raised controversies about the appropriate interpretation and the degree of bias and confounding responsible for reduced or increased risk estimates. data sources: Overall, I identified 33 epidemiologic studies in the peer-reviewed literature, most of which (25) were about brain tumors. Two groups have collected data for ≥ 10 years of mobile phone use: Hardell and colleagues from Sweden and the Interphone group, an international consortium from 13 countries coordinated by the International Agency for Research on Cancer. data synthesis: Combined odds ratios (95% confidence intervals) from these studies for glioma, acoustic neuroma, and meningioma were 1.5 (1.2–1.8); 1.3 (0.95–1.9); and 1.1 (0.8–1.4), respectively. conclusions: Methodologic considerations revealed that three important conditions for epidemiologic studies to detect an increased risk are not met: a) no evidence-based exposure metric is available; b) the observed duration of mobile phone use is generally still too low; c) no evidence-based selection of end points among the grossly different types of neoplasias is possible...
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...EFSA Scientific Report (2009) 231, 1-107 SCIENTIFIC COOPERATION AND ASSISTANCE SCIENTIFIC REPORT OF EFSA Review of the potential health impact of β-casomorphins and related peptides 1 Report of the DATEX Working Group on β-casomorphins (Question N° EFSA-Q-2008-379) Issued on 29 January 2009 WORKING GROUP MEMBERS Ivano De Noni, Richard J. FitzGerald, Hannu J. T. Korhonen, Yves Le Roux, Chris T. Livesey, Inga Thorsdottir, Daniel Tomé, Renger Witkamp. 1 For citation purposes: Scientific Report of EFSA prepared by a DATEX Working Group on the potential health impact of β-casomorphins and related peptides. EFSA Scientific Report (2009) 231, 1-107 © European Food Safety Authority, 2009 Review of the potential health impact of β-casomorphins and related peptides SUMMARY Proteins are a very diverse family of large organic compounds involved in many important biological processes. Following their enzymatic hydrolysis during food processing or digestion, proteins may release fragments from their primary amino acid sequence. These fragments are called peptides, and many of them are known to be physiologically active. The possible beneficial effects of bioactive peptides have attracted increasing interest in recent years. On the other hand, there are also reports suggesting that some food-derived peptides might adversely affect human health. Among these, β-casomorphin-7 (BCM7), a peptide sequence present in the milk protein β-casein, has been suggested to...
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...sonicating 1 mM PIP2 (Boehringer Mannheim) in distilled water. Reconstituted monoclonal PIP2 antibody (Perspective Biosystems, Framingham, MA) was diluted 40-fold into experimental solution. Current–voltage relations of all currents reversed at EK and showed characteristic rectification, mostly owing to the presence of Na+ in FVPP and possibly also residual polyamines. Current records presented (measured at 30 C, −30 mV holding potential) are digitized strip-chart recordings. Purified bovine brain Gbg29 was diluted just before application such that the final detergent (CHAPS) concentration was 5 M. Detergent-containing solution was washed away thoroughly before application of PIP2, because application of phospholipid vesicles in the presence of detergent usually reversed the effects of Gbg; presumably, Gbg can be extracted from membranes by detergent plus phospholipids. Molecular biology. R188Q mutation was constructed by insertion of the mutant oligonucleotides between the Bsm1 and BglII sites of pSPORT– ROMK1 (ref. 11). A polymerase chain reaction (PCR) fragment (amino acids 180–391) from pSPORT–ROMK1 R188Q mutant was subcloned into pGEX2T vector (Pharmacia) for expression of R188Q mutant protein of GST–RKC. The construction, expression and purification of GST–IKC (amino acids 182– 428 of IRK1), GST–GKC (180–462 of GIRK1), GST–IKN (1–86 of IRK1) have been described21,22. 3 In vitro PIP2 binding assay. H-PIP2 in chloroform-methanol (1:1) (American Radiolabeled Chemicals; 0.4 Ci nM−1 specific...
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...DETERMINING EFFECTIVESS OF DELTAMETHRIN AND CARBOSULFAN, AND THEIR SYNERGIST EFFECT IN CONTROL OF MOSQUITOES BY OCHIENG’ JAMES WYCLIFFE S12/21157/12 A research proposal submitted to the Department of Biochemistry and Molecular Biology in partial fulfillment of the requirements for the award of Bachelor of Science in Biomedical Science & Technology of Egerton University. EGERTON UNIVERSITY 2015 DECLARATION I, Ochieng’ James Wycliffe, hereby declare that this proposal is my original work and has not been presented for award of a degree in any other university. Candidate: Sign ……………………………… Date……………………………….. …. RECOMMENDATION Supervisors: This proposal has been submitted for examination with my approval as supervisor Dr. Vincent Adunga, Department of Biochemistry and molecular Biology, Egerton University. Sign: …………………………………………Date: …………………………………… ABSTRACT The development and spread of insecticide resistance in the population of Anophene species, a major vector of malaria in Kenya, presents a serious threat to the progress made in malaria control interventions. This has significantly contributed to negative gains in eradication of mosquito population that spread malaria hence increased cases of deaths due to the disease. With this resistance to insecticides on the rise, surveillance of the target population for optimal choice of insecticides is a necessity. The objective of this study is thus to assess the level of insecticides...
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...Energy Drinks: An Assessment of Their Market Size, Consumer Demographics, Ingredient Profile, Functionality, and Regulations in the United States M.A. Heckman, K. Sherry, and E. Gonzalez de Mejia ABSTRACT: The consumption of energy drinks is rapidly increasing, as demonstrated by their large market growth. The targeted demographic group is teenagers, young adults, 18 to 34 y old; although expansion into nontraditional markets is also occurring. It is claimed that energy drinks can offer an increased energy boost related to their ingredient profile of caffeine, taurine, herbal extracts, and vitamins. Research suggests that energy drink formulations, in addition to increasing energy utilization, may also improve mood, enhance physical endurance, reduce mental fatigue, and increase reaction time. However, in most cases, the corresponding mechanisms of action are not clear. In addition, concerns have been raised over their safety and with a currently weak regulatory environment, efforts need to be made to ensure consumer safety. The objective of this article is to review the current U.S. energy drink market with emphasis on its market size, target demographic, active ingredients, potential benefits, safety, and regulations. Introduction Energy drinks refer to beverages that contain, besides calories, caffeine in combination with other presumed energy-enhancing ingredients such as taurine, herbal extracts, and B vitamins. They first appeared in Europe and Asia in the 1960s in...
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...Peer-Reviewed Journal Tracking and Analyzing Disease Trends pages 557–740 EDITOR-IN-CHIEF D. Peter Drotman Associate Editors Paul Arguin, Atlanta, Georgia, USA Charles Ben Beard, Ft. Collins, Colorado, USA Ermias Belay, Atlanta, Georgia, USA David Bell, Atlanta, Georgia, USA Sharon Bloom, Atlanta, GA, USA Mary Brandt, Atlanta, Georgia, USA Corrie Brown, Athens, Georgia, USA Charles H. Calisher, Ft. Collins, Colorado, USA Michel Drancourt, Marseille, France Paul V. Effler, Perth, Australia David Freedman, Birmingham, Alabama, USA Peter Gerner-Smidt, Atlanta, Georgia, USA Stephen Hadler, Atlanta, Georgia, USA Nina Marano, Nairobi, Kenya Martin I. Meltzer, Atlanta, Georgia, USA David Morens, Bethesda, Maryland, USA J. Glenn Morris, Gainesville, Florida, USA Patrice Nordmann, Fribourg, Switzerland Didier Raoult, Marseille, France Pierre Rollin, Atlanta, Georgia, USA Ronald M. Rosenberg, Fort Collins, Colorado, USA Frank Sorvillo, Los Angeles, California, USA David Walker, Galveston, Texas, USA Senior Associate Editor, Emeritus Brian W.J. Mahy, Bury St. Edmunds, Suffolk, UK Managing Editor Byron Breedlove, Atlanta, Georgia, USA Copy Editors Claudia Chesley, Laurie Dietrich, Karen Foster, Thomas Gryczan, Jean Michaels Jones, Shannon O’Connor, P. Lynne Stockton Production William Hale, Barbara Segal, Reginald Tucker Editorial Assistant Jared Friedberg Communications/Social Media Sarah Logan Gregory Founding Editor Joseph E. McDade, Rome, Georgia, USA Emerging Infectious Diseases...
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...of precautionary health protection April 2000 ECOLOG-Institut Translated by Andrea Klein Mobile Telecommunications and Health Review of the Current Scientific Research in view of Precautionary Health Protection Commissioned by T‐Mobil DeTeMobil Deutsche Telekom MobilNet GmbH Authors Dr Kerstin Hennies Dr H.‐Peter Neitzke Dr Hartmut Voigt With the support of Dr Gisa‐Kahle Anders ECOLOG‐Institut für sozial‐ökologische Forschung und Bildung gGmbH Nieschlagstrasse 26 30449 Hannover Tel. 0511‐92456‐46 Fax 0511‐92456‐48 Email mailbox@ecolog‐institut.de Hannover, April 2000 Contents 1 1 1.1 1.2 2 Introduction 1 3 New Technologies and Precautionary Health Protection Terms of Reference and Structure of the Review 5 2.1 2.2 3 Collating and Interpreting the Scientific Data (Methodology) 5 5 Primary Reciprocal Effects between High Frequency Electromagnetic Fields and Biological Systems (Biophysical and Biochemical Processes) 3.1 3.2 3.3 3.4 3.5 4 Thermal Effects 3.1.1 Effects of Homogenous Warming 3.1.2 Microthermal Effects Direct Field Effects 3.2.1 Effects from the Electrical Component of the Electromagnetic Field 3.2.2 Effects from the Magnetic Component of the Electromagnetic Field Quantum Effects Other Effects Particular Properties of Pulsed Electromagnetic Fields ...
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