The conquest of commerce via the Internet or mobile is one of the biggest challenges that countries in development such as Ghana are confronted. The electronic environment is constantly changing and increasingly and demand the use of new technologies to companies wishing to make a place in this new world. Electronic commerce has been facilitated by the development of international trade. The opening of new markets in addition to the technological development has facilitated the exchange of information and increase productivity and sales. In order to be in this boom, many companies have started to head down in electronic commerce and don’t take into account major challenges identified. The first aspect that should ensure companies in opening an online store is the change in consumer behavior. The study of the state of the consumer to appropriate technologies and their use, without neglecting the acceptance of new modes of delivery becomes the first challenge facing the new world company. Also afford to drive the old consumers into the e-commerce and at the same time be able to get new one and make them stay on the long way remains a major challenge for companies. . Then the company will turn on the possibility and feasibility to be followed in this new world by its customers again gained in their brick and mortar. It will ensure their ability to be able to make online purchases and more of its own capacity to provide an online service as effective as physical service. To do this, it should not overlook the costly fees for most of the time very expensive of agents responsible for ensuring continuous updating and maintenance of the online site. Finally the company must reassure customers about security settings and privacy of commercial transactions. The customers now through e-commerce will have a way to easily compare prices. They can play is the competition and