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折耳猫基因缺陷Scottish Fold disease – osteochondrodysplasia
The Scottish Fold breed of cat has a genetic mutation that affects the development of cartilage. The most obvious outward manifestation of this is making the ear cartilage fold so the ears bend forward, giving the cat its characteristic appearance.
Unfortunately, the genetic defect that causes abnormality of the ear cartilage also causes severe abnormalities of the cartilage of bones – there will be defective bone development and severe bone and cartilage abnormalities in all cats with folded ears. These bone abnormalities lead to severe and painful arthritis.
The genetics of osteochondrodysplasia
The mutation causing osteochondrodysplasia results from a single autosomal dominant gene, although the gene may have incomplete penetrance, and thus the abnormalities may vary in severity between one cat and another.
All Scottish Fold cats suffer from variable degrees of painful degenerative joint disease, which can result in fusing of the tail, tarsi (ankles) and stifles (knees). This is apparent clinically as a reluctance to move, and abnormal posture and gait, lameness and short misshapen limbs.
International Cat Care believe that it is simply unethical to continue to breed cats with a genetic mutation that is known to cause significant painful disease – the rationale for breeding these cats was purely human pleasure, as some people believe the folded ears look appealing. This is an unnatural appearance for a cat though, and the underlying genetic defect has far reaching and severe consequences for the health of the cat.
More information is needed about other breeds of cats with folded or curly ears before we can be certain that they too do not have defects that may cause other problems. http://icatcare.org/advice/cat-health/scottish-fold-disease-%E2%80%93-osteochondrodysplasia Avoiding Unethical Breeders and What it Means to Rescue –
While many may not have ill intentions, backyard breeders are a major contributing factor to the pet overpopulation problem in the United States. They may not be necessarily breeding in their backyards, but this term encompasses any breeder who breeds for profit or who simply just lets their pets reproduce. According to the ASPCA, a puppy mill is “a large-scale commercial dog breeding operation that places profit over the well-being of its dogs—who are often severely neglected—and acts without regard to responsible breeding practices.” There is no way to tell if these breeders have correct and informed knowledge on proper socialization, health, nutrition, or breed standards. There is also no wholly effective way to determine a breeder's true intention as the screening process for potential homes is minimal or nonexistent. Regardless of whether the breeding was intentional or not, if someone allows two pets to breed and have a litter, they are breeders http://www.isfoundation.com/news/creatures/avoiding-unethical-breeders-and-what-it-means-rescue General approach:
澳洲RSPCA主席,是一位有三十二年经验的动物外科医师Hugh Wirth认为:「某些纯种狗,譬如贵宾犬和Cavalier King Charles猎犬,带有谜一般的基因缺陷,除非经过遗传学家来筛检,不然的话应停止买卖。
ANKC已成立遗传疾病委员会,调查研究如何避免遗传疾病
ASAP宠物基因测试公司 ASAP is currently working with Mars Veterinary on developing a Wisdom PanelTM Insights breed identification test for Australia. Already available in the US, Canadian and UK markets, the test identifies over 190 breeds, the diseases that can affect those breeds and information on the possible size of the dog. Having information on your dog’s ancestry means you can tailor what Mars calls a ‘wellness program’ to fit its individual needs.
AHT
合作对象:英国皇家防止虐待动物协会RSPCA(Royal Society of Preventing Crulty to Animal) http://www.rspca.org.uk/home 动物医学专家 Dr.Chin http://dogsnsw.org.au/resources-sp-1371102451/dogs-nsw-magazine/articles/articles-breeding/289-testing-123.html Pet owners are also availing themselves of this service, according to Dr Amanda Chin from Animal Network. “As inherited disease awareness increases we’ve seen an increase in the number of tests requested by pet owners who have recently purchased a pedigree dog as a pet,” Dr Chin says. “We encourage breeders and pet owners to always ask for a history of inherited disease in a pedigree line before purchasing a dog.”
Dr.Peter
Dr Peter Higgins, a veterinary surgeon and member of the ANKC Canine Health Committee, says the ANKC recommends DNA testing for all stud dogs so that breeders know all they can about their dogs’ health and the health of future litters.
ANKC
ASAP http://www.breedid.com.au/
Reference:
Articles:
Some practical solutions to welfare problems in dog breeding http://firefly.vetsci.usyd.edu.au/research/disorders/documents/solutiondogbreeding.pdf Population structure and genetic heterogeneity in popular dog breeds in the UK http://www.sciencedirect.com/science/article/pii/S1090023312003504 Selection for breed-specific long-bodied phenotypes is associated with increased expression of canine hip dysplasia http://www.sciencedirect.com/science/article/pii/S1090023309004432 Others: http://ankc.org.au/media/1038/154519ankc_protocols_for_dna_oct10b.pdf http://www.dogsact.org.au/ANKC%20Media/ANKC_Ltd_Breeder_Guidelines.pdf
Humans have been domesticating animal for thousands of years which is a great milestone in the development of human civilization. The most crucial role pets play in our lives is that they love us uncritically and without reserve. There is no doubt that many of us admit pets into intimate areas of our lives. However, due to the lack of breeding knowledge or the behavior of unethical breeding, many kinds of genetic diseases begins to affect the health of our pets. The Scottish Fold is a kind of varyingly known cats which has a genetic mutation that affects the development of cartilage. The Scottish Fold has characteristic appearance that their ears bend forward. Unfortunately, the genetic defect that causes abnormality of the ear cartilage also causes severe abnormalities of the cartilage of bones – there will be defective bone development and severe bone and cartilage abnormalities in all cats with folded ears. These bone abnormalities lead to severe and painful arthritis. Another example is German Shepherd had canine hip dysplasia defects(CHD) because of inbreeding. Dr Amanda Chin is Business Manager of the Animal Products Division at Animal Network, the animal DNA testing business of Genetic Technologies. Due to the cruel phenomenon, people pay more attention to the genetic problem before their pets breeding. Dr Amanda Chin who is Business Manager of the Animal Products Division at Animal Network, the animal DNA testing business of Genetic Technologies said “As inherited disease awareness increases we’ve seen an increase in the number of tests requested by pet owners who have recently purchased a pedigree dog as a pet,” Dr Chin says. “We encourage breeders and pet owners to always ask for a history of inherited disease in a pedigree line before purchasing a dog.”