..."Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid" was an article published by Francis Crick and James D. Watson in the scientific journal Nature in its 171st volume on pages 737–738 . It was the first publication which described the discovery of the double helix structure of DNA. This article is often termed a "pearl" of science because it is brief and contains the answer to a fundamental mystery about living organisms. This mystery was the question of how it is possible that genetic instructions are held inside organisms and how they are passed from generation to generation. The article presents a simple and elegant solution, which surprised many biologists at the time who believed that DNA transmission was going to be more difficult to deduce and understand. The discovery had a major impact on biology, particularly in the field of genetics, enabling later researchers to understand the genetic code . Origins of molecular biology The application of physics and chemistry to biological problems led to the development of molecular biology. Molecular biology is particularly concerned with the flow and consequences of biological information at the level of genes and proteins. The discovery of the DNA double helix made clear that genes are functionally defined parts of DNA molecules and that there must be a way for cells to make use of their DNA genes in order to make proteins. Linus Pauling was a chemist who was very influential in developing...
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...results in the increase in the available, accessible information for the community. Since the beginning of the century, online science journals have made the scientific community cohesive by providing with the most up to date findings for research being conducted in particular fields as well as all are new ways to “interact” amongst individuals. For this report we have chosen four online resources that provide information on the area of biomolecular biology and neurology, we will enumerate their usefulness to our particular field of interest and their incidence in our future professional careers. In the 1850’s, an Austrian monk Gregor Mendel discovered that he can manipulate plant offspring to breed plants selectively with traits that he wished to see; he cross-bred two tall pea plants and found that the offspring almost certainly expressed the "tall" feature. At the time, the scientific community was ignorant with genetic and DNA comprehension, but Mendel's work would prove to be a precursor to Darwin's evolutionary theory and eventually a foundation for all medical practice performed today. While our understanding of genetics is superb at best, new ideas and practices keep the medical field in constant progression. "Gene Editing Could Make Pig-to-Human Organ...
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...In the progress of understanding of human biology why complex diseases like diabetes, cancer, high blood pressure and psychiatric disorders are so difficult to predict and treat, or why one individual gets a disease but an identical twin remains perfectly all right, scientists have now discovered one vital clue to unravel the riddle. Human genome is a collection of 4 million gene switches. Some reside in bits of DNA that once were discarded as ‘junk’ but that turns out to play critical role in controlling how cells, tissues and organs behave -- the junk DNA is often referred to as the ‘dark matter’ instead. As a result of a huge project involving 440 scientists from 32 laboratories around the world, the discovery is considered as a major medical...
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...needing more GM foods, there are urgent reasons why we need to ban them altogether. 1. GM foods won’t solve the food crisis A 2008 World Bank report concluded that increased biofuel production is the major cause of the increase in food prices.1 GM giant Monsanto has been at the heart of the lobbying for biofuels (crops grown for fuel rather than food) — while profiting enormously from the resulting food crisis and using it as a PR opportunity to promote GM foods! “The climate crisis was used to boost biofuels, helping to create the food crisis; and now the food crisis is being used to revive the fortunes of the GM industry.” — Daniel Howden, Africa correspondent of The Independent2 “The cynic in me thinks that they’re just using the current food crisis and the fuel crisis as a springboard to push GM crops back on to the public agenda. I understand why they’re doing it, but the danger is that if they’re making these claims about GM crops solving the problem of drought or feeding the world, that’s bullshit.” – Prof Denis Murphy, head of biotechnology at the University of Glamorgan in Wales3 commercialization, genetic engineering has failed to significantly increase US crop yields. The author, former US EPA and US FDA biotech specialist Dr Gurian-Sherman, concludes that when it comes to yield, “Traditional breeding outperforms genetic engineering hands down.”6 “Let’s be clear. As of this year [2008], there are no commercialized GM crops that inherently increase yield. Similarly...
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...Genetic Engineering Wesley Rupe, Jawad Rana, Layli Stroia, Charles Taiwo, Mariella Velasquez, Mark Young DeVry University Genetic Engineering Table of contents Title page ………………………………………………………………………………………………………………………. 1 Table of contents ……………………………………………………………………………………………………………. 2 1. A brief description of the technology and an explanation of the associated science (Mariella Velasquez) ………………………………………………..……………. 3 2. Psychological considerations and sociological effects (Mariella Velasquez) …………. 3 3. The historical development and context of the technology (Wesley Rupe) …………. 13 4. Political and legal influences (Mark Young) (Not Complete) 5. Economic questions and considerations (Jawad Rana)………………………………….…… 21 6. The technology in its cultural context, media influence (Charles Taiwo) (Not Complete) 7. Implications for the environment (Charles Taiwo) (Not Complete) 8. Moral and ethical implications (Layli Stroia) ……………………………………………………..… 30 Outline A brief description of the technology and an explanation of the associated science Definition: What is Genetic Engineering? Genetic engineering (GE) is the process of manipulation of an organism genome to create a new DNA. The new DNA might be implanted in a totally different DNA species. It is widely used to create hybrids (some species are not able to naturally breed), correct genetic flows in any type of being. It is applied in...
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...DNA profiling (also called DNA testing, DNA typing, or genetic fingerprinting) is a technique employed by forensic scientists to assist in the identification of individuals by their respective DNA profiles. DNA profiles are encrypted sets of numbers that reflect a person's DNA makeup, which can also be used as the person's identifier. DNA profiling should not be confused with full genome sequencing.[1] It is used in, for example, parental testing and criminal investigation. Although 99.9% of human DNA sequences are the same in every person, enough of the DNA is different to distinguish one individual from another, unless they are monozygotic twins.[2] DNA profiling uses repetitive ("repeat") sequences that are highly variable,[2] called variable number tandem repeats (VNTR), particularly short tandem repeats (STR)s. VNTRs loci are very similar between closely related humans, but so variable that unrelated individuals are extremely unlikely to have the same VNTRs. The DNA profiling technique was first reported in 1984[3] by Sir Alec Jeffreys at the University of Leicester in England,[4] and is now the basis of several national DNA databases. Dr. Jeffreys's genetic fingerprinting was made commercially available in 1987, when a chemical company, Imperial Chemical Industries (ICI), started a blood-testing centre in England.[5] Contents [hide] 1 DNA profiling process 1.1 RFLP analysis 1.2 PCR analysis 1.3 STR analysis 1.4 AmpFLP ...
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...robinson@earthopensource.org June 2012 Disclaimer The views and opinions expressed in this paper, or otherwise published by EOS, are those of the authors and do not represent the official policy, position, or views of other organizations, universities, companies, or corporations that the authors may be affiliated with. GMO Myths and Truths 2 About the authors Michael Antoniou, PhD is reader in molecular genetics and head, Gene Expression and Therapy Group, King’s Cols: lege London School of Medicine, London, UK. He has 28 years’ experience in the use of genetic engineering technology investigating gene organisation and control, with over 40 peer reviewed publications of original work, and holds inventor status on a number of gene expression biotechnology patents. Dr Antoniou has a large network of collaborators in industry and academia who are making use of his discoveries in gene control mechanisms for the production of research, diagnostic and therapeutic products and safe and efficacious human somatic gene therapy for inherited and acquired genetic disorders. Claire Robinson, MPhil, is research director at Earth Open Source. She has a background in investigative reporting and the communication of topics relating to public health, science and policy, and the environment. She is an editor at GMWatch (www.gmwatch.org), a public information service...
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...genetically modifying food crops such as soy and corn, insect resistance and crop yield can be improved. However, studies conducted after government approval in the U.S. indicate that genetically modified (GM) foods can cause harmful side effects not only to humans but also to the environment. During the 1950’s, scientists found the basis for genetic modification when they discovered chemicals that “could cut and duplicate pieces of DNA” (Chapman, 2010, para. 2). Genetic modification occurs when the DNA from one species is inserted into the DNA of another species. For example, the gene that allows an Arctic fish not to freeze in sub-zero waters could be inserted into a tomato plant to make it frost resistant. Without the ability to cut pieces of DNA, these genes could not be transferred. The process evolved with the discovery of a germ that could transfer DNA into plants. Cells contain a natural defense mechanism that protects against a genetic invader taking over the cell; however viruses, some of which can cause cancer, can surpass these defenses. Microbiologists use a promoter from the Cauliflower Mosaic Virus (CaMV), to ensure that the genetic trait they are inserting will incorporate into the plant being modified (Smith, 2003, p.63). The promoter acts like a “light switch,” permanently turning on the...
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...Fedoroff Agric & Food Secur (2015) 4:11 DOI 10.1186/s40066-015-0031-7 Open Access REVIEW Food in a future of 10 billion Nina V Fedoroff* Abstract Over the past two centuries, the human population has grown sevenfold and the experts anticipate the addition of 2–3 billion more during the twenty-first century. In the present overview, I take a historical glance at how humans supported such extraordinary population growth first through the invention of agriculture and more recently through the rapid deployment of scientific and technological advances in agriculture. I then identify future challenges posed by continued population growth and climate warming on a finite planet. I end by discussing both how we can meet such challenges and what stands in the way. Keywords: Population growth, Agriculture, Domestication, Genetic modification, Technology Background Today we have enough food to meet the world’s needs. Indeed, we have an extraordinary global food system that brings food from all over the planet to consumers who can afford to buy it. The food price spike of 2008 and the resurgence of high food prices in recent years have had little impact on the affluent citizens of the developed world who spend a small fraction of their income on food. By contrast, food prices have a profound impact on the world’s poorest people. Many of them spend half or more of their income on food. During the food price crisis of 2008, there were food riots in more than...
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...D38–D51 Nucleic Acids Research, 2011, Vol. 39, Database issue doi:10.1093/nar/gkq1172 Published online 20 November 2010 Database resources of the National Center for Biotechnology Information Eric W. Sayers1,*, Tanya Barrett1, Dennis A. Benson1, Evan Bolton1, Stephen H. Bryant1, Kathi Canese1, Vyacheslav Chetvernin1, Deanna M. Church1, Michael DiCuccio1, Scott Federhen1, Michael Feolo1, Ian M. Fingerman1, Lewis Y. Geer1, Wolfgang Helmberg2, Yuri Kapustin1, David Landsman1, David J. Lipman1, Zhiyong Lu1, Thomas L. Madden1, Tom Madej1, Donna R. Maglott1, Aron Marchler-Bauer1, Vadim Miller1, Ilene Mizrachi1, James Ostell1, Anna Panchenko1, Lon Phan1, Kim D. Pruitt1, Gregory D. Schuler1, Edwin Sequeira1, Stephen T. Sherry1, Martin Shumway1, Karl Sirotkin1, Douglas Slotta1, Alexandre Souvorov1, Grigory Starchenko1, Tatiana A. Tatusova1, Lukas Wagner1, Yanli Wang1, W. John Wilbur1, Eugene Yaschenko1 and Jian Ye1 1 Downloaded from http://nar.oxfordjournals.org/ by guest on March 20, 2015 National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA and 2University Clinic of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Auenbruggerplatz 3, A-8036 Graz, Austria Received September 16, 2010; Revised October 29, 2010; Accepted November 1, 2010 ABSTRACT In addition to maintaining the GenBank nucleic acid sequence database, the National Center for Biotechnology...
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...curing human diseases more favorable for healing and or curing diseases more significant than the ethical concerns and arguments? I. What are stem cells? A) An unspecialized cell that can generate to one or more different types of specialized cells regenerated as blood or nerve cells. B) Stem cells are present in embryos and in tissues of adult organisms. II. How are stem cells used? A) Scientific Research B) Potential disease and treatment and or cures C) In vitro fertilization D) Cloning and Genetic Engineering III. Ethical concerns regarding stems cells. A) Scientific research perspective B) Political/Moral Ethics perspective C) Religious/Utilitarianism perspective IV. Conclusion | Stem Cells Risk or Benefit Since the introduction of DNA, scientists have researched many ways to treat and extinguish disease. One interesting way is through the use of stem cells. To get better understanding of stem cells, they are defined as non-specific biological cells capable of differentiating into specialized cells. Stems cells have a unique quality of developing and duplicating cells through the process of cell division. The distinctiveness of stem cells is that they are unspecialized, meaning no specific function, making them capable of mimicking and regenerating neighboring blood and nerve cells. Stem cells are present in multi-cellular organisms...
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...What is Cloning? Clones are organisms that are exact genetic copies. Every single bit of their DNA is identical. Clones can happen naturally—identical twins are just one of many examples. Or they can be made in the lab. Below, find out how natural identical twins are similar to and different from clones made through modern cloning technologies. How Is Cloning Done? Many people first heard of cloning when Dolly the Sheep showed up on the scene in 1997. Artificial cloning technologies have been around for much longer than Dolly, though. There are two ways to make an exact genetic copy of an organism in a lab: artificial embryo twinning and somatic cell nuclear transfer. 1. Artificial Embryo Twinning Artificial embryo twinning is a relatively low-tech way to make clones. As the name suggests, this technique mimics the natural process that creates identical twins. In nature, twins form very early in development when the embryo splits in two. Twinning happens in the first days after egg and sperm join, while the embryo is made of just a small number of unspecialized cells. Each half of the embryo continues dividing on its own, ultimately developing into separate, complete individuals. Since they developed from the same fertilized egg, the resulting individuals are genetically identical. Artificial embryo twinning uses the same approach, but it is carried out in a Petri dish instead of inside the mother. A very early embryo is separated into individual cells, which are allowed...
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...assumption that they increase crop yields. Although the long term health, environmental, and economical effects of genetically modified organisms is not fully understood, the majority of people from around the world are leery and therefore opposed to the use of genetically modified organisms. This research paper will attempt to analyze the health, environmental and economical issues surrounding genetically modified organisms. According to Dictionary.com, “A GMO is an organism whose genome has been altered by the techniques of genetic engineering so that its DNA contains one or more genes not normally found there.” Genetically Modified Organisms are most commonly used in the agricultural business, where companies like Monsanto have genetically engineered “hybrid” seeds. For example, Round-up Ready corn that is corn that has had its DNA modified to withstand the herbicide Round Up. Also, another example is strawberries and tomatoes that have had their DNA injected with fish genes to protect the fruit from freezing. Genetically Modified...
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...power distribution systems, supported by similar findings in adults in several occupational studies also involving electrical power frequency exposures, show a consistent pattern of response that suggests, but does not prove, a causal link. Frequency components higher than 60 Hz cannot be ruled out as contributing factors. Evidence from a large number of biological test systems shows that these fields induce biological effects that are consistent with several possible mechanisms of carcinogenesis.” This situation suggests the need to continue to evaluate the information from ongoing research and to further evaluate the mechanisms of carcinogenic action and the characteristics of exposure that cause these effects. A Medscape (2000) review article concludes (Siepmann, 2004): “Taken together,...
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...Unit II: Genetics Brief Overview Reading: Chapters 3, 4, 9-12, 14 (Note: you have reviewed much of this already) The earth is teeming with living things. We can easily see some of the larger organisms—trees, grass, flowers, weeds, cats, fish, squirrels, dogs, insects, spiders, snails, mushrooms, lichens. Other organisms are everywhere, in the air, in water, soil and on our skin, but are too small to see with the naked eye—bacteria, viruses, protists (single celled eukaryotes such as amoebae), and tiny plants and animals. Life is remarkable in its complexity and diversity, and yet it all boils down to a very simple idea—the instructions for making all this life are written in nucleic acids, usually DNA. Most organisms have a set of DNA that contains the instructions for making that creature. This DNA contains four “letters” in which these instructions are written—A, T, G, and C. The only difference between the code for a dog and the code for a geranium is in the order of those letters in the code. If you took the DNA from a human and rearranged the letters in the right way, you could produce an oak tree—arrange them slightly differently and you would have a bumble bee—arrange them again and you would have the instructions for making a bacterium. Acting through more than two billion years, the process of evolution has taken one basic idea—a molecular code that uses four letters—and used it over and over, in millions of combinations to produce a dazzling array of life forms...
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