Generally, Tokyo and Osaka are the two major cities is the two major cities in Japan that have a very different characteristic.
Culture of Tokyo vs Culture of Osaka

Udagawa(n.d.) states that “Originally, there are difference between food culture between Kansai and Kanto and meat is preferred to pork in Kansai. Brand meat such as Matsuzaka meat, Kobe meat and Oumi meat represent this culture and consumption rate of meat per family in Kansai is higher than that of Kanto. In other hand, consumption rate of port per family in Kanto is higher than that of Kansai. It is common for Kansai people to use meat and Kanto people to use pork for cooking Nikujaga, the traditional Japanese home cuisine.”(my translation)

関西と関東の食文化の違いにより，もともと関西は豚肉より牛肉が好まれる。松阪牛，神戸牛，近江牛など関西には牛肉のブランドも多く，一戸あたりの牛肉の消費量は関東よりも多い。逆に関東は豚肉の消費量が関西より多い。肉じゃがの肉も関西では牛肉，関東では豚肉が主流とか。

Gajet of Gajetdaisuke.com explains that while people in Tokyo emphasis on building their career since many of them are responsible for dealing a big projects, people in Kansai emphasis on money because many of them are doing a small business such as running a small manufacturing company or small shop. Kansai peoples are so keen to the money that few people in Kansai receive social aid and few people become a victim of fraud compared to other regions(2010).

東京のように何億円規模のビッグプロジェクトがばんばん乱立してる世界ではシゴト自体に重点を置くのでしょうが、町工場とか個人商店とか職人とかの気質がそのまま活きてる関西では悪い意味ではなく身近な金額のお金についてもっと普段から重視

してる印象があります。そのスタンスは生活保護をうける率とか振り込め詐欺に騙されない率とか、そういうところにも大きく関係してそうですね。

Hattori explains that in Edo era, very few Samurai lived in Osaka and majority of citizens in Osaka was merchandiser. They made an important role to rule the Osaka region in terms of politics and economics(2008).