...Epigenetics What is epigenetics? Epigenetics refers to external modifications to DNA that turns genes "on" or "off". The DNA sequence is not changed, these modifications just affect how the genes are read. Epigenetic regulation involves the modification of DNA and the proteins associated with DNA, which results in changes to the conformation of DNA without a change in its sequence. In some cases, epigenetic modifications are stable and passed down to future generations, but in others cases they are dynamic and change in response to environmental stimuli. Two common molecular mechanisms that regulate epigenetics are DNA methylation and histone modifications. Epigenetic processes are essential for development and differentiation, but they...
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...The field of epigenetics allows us to get a better understanding of the effects of stress and how it can have a prolonged impact on gene activity. Many studies(N.A Hazel et al., 2005, V.J. Felitti 2002, Franklin et al., 2010) carried out on humans and animals have shown that even early life stress can lead to epigenetic changes which can affect us in adulthood. These changes can make us more susceptible to many neuropsychiatric and cardiovascular disorders. In a study carried out by Nätt et al., 2015 the epigenetic mechanisms caused by high stress levels were studied in children. They measured the levels of cortisol in children’s hair (assuming that stress levels were correlated with cortisol levels), according to this the children were divided into high and low stress groups....
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...What is Epigenetics? Conrad Waddington presented the term epigenetics in the early 1940s. Epigenetics referred to all molecular passageways moderating the expression of a genotype into a particular phenotype. The term epigenetics refers to heritable variations in gene expression that does not include changes to the original DNA sequence. It is actually a change in phenotype without a change in genotype. Epigenetic change is a consistent and natural existence but can also be influenced by several factors including age, the environment and disease state. Epigenetic change can have more destructive effects that can result in diseases like cancer. At least three systems including DNA methylation, histone modification and non-coding RNA are considered...
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...Santina Wood ENG101 Argosy University 03/4/2014 Instructor Benjamin Atkins Epigenetics -vs- Nature -vs- Nurture The nature vs nurture debate is still ongoing, and within this debate, the world of science and psychology are faced with two new questions. Today we find some researchers asking; "Is development predetermined at birth, by hereditary factors, or do experience and other environ -mental factors affect it?", and "Can the two work together in shaping human development and behavior?" Developmental psychologists still attempt to find the answers to these questions in order to discover the sources of growth in children's cognitive, language, and social skills. Most developmental psychologists believe that nature and nurture combine to influence biological factors playing a stronger role in some aspects, such as physical development, and environmental factors playing a stronger role in others, such as moral development. They are also beginning to acknowledge the role of a variable combination of both inborn factors and social experiences when explaining children's behavior. Scientists and Psychologists have a name for such an occurrence; epigenetics/epigenesis. In this essay, I will be presenting to my audience information on this highly, and sometimes heated debate, as well as the reasons as to why the belief of this dual influence called epigenetics is becoming more fact than theory. For as long as there has been life, and those...
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...Are Imprinted Genes Adaptive or Maladaptive? Epigenetics is referred to be the study of heritable changes other than those in the DNA sequence that encompass two major modifications of DNA or chromatin: DNA Methylation, the covalent modifications of cytosine, and post-translation modification of histones including methylation that is a highly intricate process that occurs within each cell as well as supplying fluid in the brain and within the liver, acetylation , phosphorylation and sumoylation (Callinan and Feinberg 2006) which is the is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle . Epigenetics is the mechanism that leads to parent-of-origin effects via imbalanced expression of maternally and paternally inherited copies of a gene. It plays a role in several Mendelian diseases and there is growing evidence for its role in common diseases as well as cancer. It is a dynamic mechanism with varying degrees of monoallelic expression between tissues and developmental stages (Wolf et al. 2008; Kong et al. 2009; Skaar et al. 2012; Lawson et al. 2013; Peters 2014). In addition, recent evidence suggests that noncoding RNAs predominantly microRNA contribute to the stock of epigenetic mechanisms that are found in major diseases and that can occur at critical developmental times (Esteller 2011)...
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...when sales slump or drop off? or how to handle stress situation of sales target, manage sales team diversity and so on) 3. Describe the Process of Selling and Buying of B2B or B2C from the experiences shared by the sales manager (guest speaker) and provide practical examples to illustrate, included: c) How to prospecting a customers d) How to building rapport e) Discuss critical aspects in relationship selling 4. Sales Performance and Others a) Discuss recruitment and selection b) Leadership and motivating sales forces c) Leadership and motivating sales forces d) Compensation, incentives, non-financial reward and personal satisfaction 5. Conclusion (5) a) Discuss your own point of view regarding the challenges. Group mark: _______/100% ___________________ Grade RULES OF THUMB The creativity of the report presentation, analysis and idea arrangement is highly marked The credibility of information source/reference must be guaranteed Quality not quantity! ASSIGNMENT 2 - B2B/B2C SALES CALL PRESENTATION BA032IU SALES MANAGEMENT Presentation Marking Sheet Group: _______________________ Date: ________________ c) Quality of presentation (preparation, speech and clarity) 1 2 3 4 5 d) Content (level of research and relevance of information) 1 2 3 4 5 e) Using multiple mediums (photos, videos, music, in-class enactments etc) 1 2...
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...UNIVERSITY OF EAST ANGLIA NORWICH BUSINESS SCHOOL UG/PG Coursework 2012-2013 MODULE: NBS- MC03 Marketing and Strategy: Markets, Competitors, and Customers – REASSESSMENT COURSEWORK Note: This is an individual assignment in which all of the work must be done by you alone. Question: “How well will the company do? Analyse the strategy and marketing of an existing company of your choice. Use your analysis to predict how successful it might be in future and make specific recommendations on how and why it should change its strategy and / or marketing” You are required to write a discussion paper that includes your strategic and market based analysis of the company, its competitive environment now and in the future, how successful you believe it will be in the future based upon its existing strategy and marketing, and how you would recommend it change its strategy and/or marketing to be more successful in the future. Submission deadline: 15th April 2013 no later than 3pm Word limit: 2,000 words This is a discussion paper and not a business plan. In addition to your main analysis and discussion, your paper you should include: • An Executive Summary (max 200 words) • Appendices – where you can put your supporting information. These are not marked but are helpful for the marker to see. They are not part of the word count. Suggestions for how to use the appendices, e.g. if you do a PESTLE analysis you put the detailed PESTLE in the appendix and...
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...EXECUTIVE SUMMARY PURPOSE The purpose of this report is to assess the compliance of Nightingale Community Hospital (NCH) in accordance with the Joint Commission’s National Patient Safety Goals for 2012. This report will focus exclusively on the Priority Focus Area of Communication and its subsequent standards: * UP.01.01.01 – Conduct a preprocedure verification process. * UP.01.02.01 – Mark the procedure site. * UP.01.03.01 – A time-out is performed before the procedure. BACKGROUND NCH is 13 months away from its next Joint Commission audit. It is imperative that NCH is in complete compliance with the Joint Commission. METHODOLOGY In order to determine the degree of compliance with the aforementioned standards, the following NCH documents were cross-referenced: * Preprocdure Hand-Off >cross-referenced with standard UP.01.01.01 * Site Identification and Verification >cross-referenced with standard UP.01.02.01 * Site Identification and Verification, subheading Time-Out Procedure >cross-referenced with standard UP.01.03.01 FINDINGS Standard UP.01.01.01. NCH is not in compliance with standard UP.01.01.01. The first element of performance of this standard requires NCH to conduct a preprocedure verification process. Although NCH currently has a Preprocedure Hand-Off form that highlights the process, it could be improved by the inclusion of more precise language. Three recommendations are suggested for this improvement: (a) procedure...
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...How do you correct your student’s grammar mistakes? Instructors often lament the sloppiness of their students’ writing. Grammatical problems abound in college student writing, and when student papers are filled with errors, many teachers feel obligated to correct every sentence-level error they see. While marking each error can be an extremely time-consuming task, it is always the hope that students will read these comments and learn from the corrections. Is this really what happens? Is the time well spent? Unfortunately correcting errors for students will probably not help them learn to correct errors themselves. Only the most conscientious students will pour over your comments and reach for their grammar handbooks for additional information. Rather, in cases where every error is marked and corrected, the student will likely believe that the instructor has done all the work, and that little revision is necessary beyond that indicated by the corrections. If students are not given a chance to revise work, chances are good that they will not attend to your comments at all. Another downfall to correcting every spelling, punctuation, grammar, and capitalization error in a student paper is that it can end up taking the focus of your comments off the content and organization of the piece. Even if you are careful to attend to both mechanics and content, it is important to keep in mind that students can be easily overwhelmed...
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...This can only be done if each tool has a specific place where it is stored that allows for quick identification if the tool is missing. There are several ways to do this. Tool shadowing This involves specifying a specific space for each tool. It should be designed in such a way as to quickly determine if a tool is missing. A popular method is to use some type of foam product and cut out spots for each tool. In a toolroom environment, walls can be used with pegboard and hooks. The item is then outlined and shadowed. Tool identification Some companies require employees permanently mark their tools for tool identification purposes. This provides a way to quickly identify who a tool belongs to when it is found. Tools can be marked using a vibra-peen tool. Some other marking methods such as permanent marker may not be very effective in a hangar environment. If your company requires mechanics to mark their personal tools in a uniform method, be careful of the requirement. It would be best to use mechanics’ initials or the last four digits of their Social Security number as a tool ID marking. Company specific numbers such as employee numbers should be avoided. If the mechanic changes jobs to another company, these numbers will not be...
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...------------------------------------------------- Top of Form Bottom of Form * Home * My Qualification * Assessments * Study resources * The Cafe * Media Lounge Hints and tips for writing assignments What follows are some tips which should help you when you are preparing for the assignment route of assessment. Your tutors are likely to use contact time in a different way than if they are preparing you for examinations – as well as covering the theory, more time may be spent debating the application of theory to practice, and perhaps using the assignment as a basis for some discussion. Studying and preparing assignments Any studying member who require support in preparing and writing assignments should contact their tutor/study centre for advice and assistance. Guidance on formats for assessments Please be advised that there is not a prescriptive approach to producing documents for assessment. The content and structure of the document depends upon the audience addressed and the subject matter. You can undertake research on different types of documents by looking at what is available on the internet. For example, putting in the words “discussion papers for conferences” brings up a wide variety of discussion papers for a conference audience. To view more examples download our Guidance on formats for assessments. Check our Command words guide: when answering your questions on your assignment, it is important to ensure you have interpreted what...
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...ensure information is communicated; however, there are areas lacking in the hand-off form. Although the current hand-off form has an area to verify the patient identification/armband and if the site has been marked, there is no area to verify the patient procedure and the procedure site thus leaving the hospital not in compliance with the standard. 2. Identify the items that must be available for the procedure and use a standardized list to verify their availability. NCH is also not compliant in this standard as, again, the hand-off form does not have an area that identifies items needed for the patient’s procedure, nor is there any other form identified in the written policy that addresses this element of performance. UP.01.02.01: Mark the procedure site – This Element of Performance is in place to ensure that wrong site surgeries do not happen...
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...be inserted at the field board): Number of students registered: Number of students assessment 1: Number of students assessment 2 (where applicable): Number of students provisionally awarded a Module Pass at the examination board in June/July for undergraduate programmes: Module Co-ordinator : Peter Walker Date 24 May 2011 | Assessment Report: Overview of how well students handled the assessment 1 (for example how well students understood material, met expectations, integrated knowledge, language skills, etc) 1. Overall this year’s cohort performed very well; 147 students took the assessment of these 5 obtained marks in the 1st class category, 68 obtained 2:1, 54 2:2, 16 3rd class and 4 students failed. In percentage terms this is a 97% pass rate. With the average mark skewed towards the 2:1 level. Given that a significant number of the students were on our top up degrees programme and therefore did not have English as their first language, this was a particularly gratifying result. (handling of specific questions/sections and strengths/weaknesses in relation to each question ) 1. The exam is separated into two sections, section A was related to a case study that the students received around 3 weeks prior to the examination and section B addressed some of the conceptual material from the module. In general students handled section A, very well, having been briefed on the key issues, they prepared themselves well for the...
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...2- Body In MotionAssessment Task Number: 2Weighting: 25%Due Date: 31 July 2015 (Term 3 Week 2)Task Title: Training ProgramTotal Marks: 50Draft and Review: 10 marksFinal Submission: 40 marksOutcomes: P7, P8, P10, P11, P17 | Context Coaching staff of high representative sporting teams/individuals will always plan training programs to effectively develop their teams or athletes. They will use various methods and techniques when designing these programs so that athletes can develop their fitness and skills. Task Choose a sport of your choice. This sport will be your focus in completing each section of this task. Part A- Draft and Review 10 Marks To gain 10 marks you need to complete the following * Submit at least 1 draft to a friend for “peer-feedback” * Submit at least 1 draft to the teacher for feedback * Complete Part A Student Reflection and submit sheet on assessment submission * Complete Part B Student Reflection and submit within 24 hours of assessment being returned. Part B- Training Program 20 Marks Design a week long training program using the FITT principles. Ensure your athletes have both anaerobic and aerobic training incorporated, in a ratio relevant for your chosen sport. You should also ensure you train the relevant health and skill related components of fitness. Part C- Report (1-2 pages) 20 Marks Justify your training program by: * Describing the changes to the musculoskeletal and cardiorespiratory systems. ...
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