...name Genetics and Genomics school Colorectal Cancer Colorectal cancer is a genetic disorder. Colorectal cancer may cause one or more of the symptoms below: • A change in bowel habits, such as diarrhea, constipation, or narrowing of the stool, that lasts for more than a few days • A feeling that you need to have a bowel movement that is not relieved by doing so • Rectal bleeding, dark stools, or blood in the stool (often, though, the stool will look normal) • Cramping or abdominal (belly) pain • Weakness and fatigue • Unintended weight loss Most of these symptoms are more often caused by conditions other than colorectal cancer, such as infection, hemorrhoids, or inflammatory bowel disease. Still, if you have any of these problems, it's important to see your doctor right away so the cause can be found and treated, if needed. (“FITWAY,” 2013) Colorectal cancer would be diagnosed after having a colonoscopy that would hopefully reveal the cause of the bleeding, change in bowels, etc. If there is colon polyps the surgeons will remove the polyps during the procedure. If the polyps and/or mass are too big to remove during the colonoscopy the surgeons will schedule patient for an abdominal procedure to remove it. Men and women both can equally be affected by colorectal cancer as they increase in age. This type of cancer occurs more often in people age 50 and over but is...
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...The difference between genomic and genetics are that genetic scrutinizes the functioning and composition of a single gene. Whereas genomics address all genes and their inter relationship in order to identify their combined effect on the function, growth and development of the whole organism (W.H.O, 2002). Medicine is an ever evolving process, healthcare benefits greatly from the unprecedented and ongoing work elucidating to the genetic/genomic basis of health, illness, disease and treatment response. Because of our understanding of the human genome has allowed us to customize treatment plans and medications. Several years ago a new drug hit the market, which specifically targeted certain types of cystic fibrosis; it was the first of its...
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...Throughout history, innovators have envisioned a better world and worked to perfect their craft in order to progress towards that ideal. It’s been shown time and time again that ideas spark inspiration, theory, experiments, and eventually that gradual scientific process inevitably leads to change. As a Biology major with a specialization in developmental genetics, I am especially interested in how we can learn from DNA, also referred to as the “blueprint of life”, to make ourselves and our world exceptional. The first method of sequencing DNA was developed in the 1970’s by Fred Sanger; this came to be known as Sanger Sequencing ("DNA Sequence Assembly"). This method uses naturally occurring DNA synthesis, which proceeds from the...
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...------------------------------------------------- University of Phoenix Material Vertebrates and Invertebrates Worksheet PART 1: Compare vertebrates and invertebrates. Directions: In the graphic below, compare vertebrates and invertebrates by: * Create a list of 5 characteristics that make vertebrate and invertebrates different * Create a list of 5 characteristics that make vertebrate and invertebrates similar differences | similarities | Vertebrates are comprise to all species of animails within the subphylum vertebrata (chodates with back bones). | Many invertebrates taxa have a greater number and variety of species than the entire subphylum of vertebrata. Some of the so-called inverterbrates, such as chaetognatha, hemichordate, tunicate, and cephalochordate are more closely related to the vertebrates than to other invertebrates. | Inverterbrates are animals that nethier possess nor develop a vertebral colum, derived from the notochord. This includes all animals apart from the subphylum vertebrata. | This makes the term “ invertebrate” paraphyletic and hence almost meaningless for taxonomic purposes. | Vertebrates include, the jawless fish and the jawed vertebrates, which includes the cartilaginous fish (shark and rays) and the bone fish. A bony fish clade known as the lobe-finned fishes included with tetrapods, which are further divided into. | The vertebrates traditionally include the (hagfish), which do not have proper vertebrae, though their...
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...McKinsey Global Institute May 2013 Disruptive technologies: Advances that will transform life, business, and the global economy The McKinsey Global Institute The McKinsey Global Institute (MGI), the business and economics research arm of McKinsey & Company, was established in 1990 to develop a deeper understanding of the evolving global economy. Our goal is to provide leaders in the commercial, public, and social sectors with the facts and insights on which to base management and policy decisions. MGI research combines the disciplines of economics and management, employing the analytical tools of economics with the insights of business leaders. Our “micro-to-macro” methodology examines microeconomic industry trends to better understand the broad macroeconomic forces affecting business strategy and public policy. MGI’s in-depth reports have covered more than 20 countries and 30 industries. Current research focuses on four themes: productivity and growth, the evolution of global financial markets, the economic impact of technology and innovation, and urbanization. Recent reports have assessed job creation, resource productivity, cities of the future, and the impact of the Internet. MGI is led by McKinsey & Company directors Richard Dobbs and James Manyika. Yougang Chen, Michael Chui, Susan Lund, and Jaana Remes serve as MGI principals. Project teams are led by a group of senior fellows and include consultants from McKinsey’s offices around the world...
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...call the “warrior gene” which is aggressive. The actual name is MAOA. Some are using this as a defense when a person is being tried for a violent crime. Also research of violent and aggressive psychopathic individuals have proven that several biological markers do exist and these are; lowered heart rate, abnormal EEG, multiple abnormalities in right temporal lobes and greater abnormalities in left temporal lobes. Scientist have also discovered prefrontal damage encourages; risk taking, irresponsibility, rule-breaking, emotional and aggressive outburst, argumentative, violent criminal acts, loss of self-control, immaturity, lack of tact, inability to modify and inhibit behavior appropriately, poor social judgment and violence. Our genetics is a set of building blocks that dictate among other things how our brains are built, function and get wired together. Every thought, emotion or...
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...Erlangen-Nuremberg, Erlangen, Germany; 6Department of Pediatrics and Adolescent Medicine, University of Ulm, Ulm, Germany; 7Institute of Pharmacological Biology/DCAL, Goethe-University, Frankfurt, Germany; and 8Onkogenetic Laboratory, Department of Pediatric Hematology/Oncology, Justus-Liebig-University, Gießen, Germany 1Children’s Approximately 25% of childhood acute lymphoblastic leukemias carry the ETV6/RUNX1 fusion gene. Despite their excellent initial treatment response, up to 20% of patients relapse. To gain insight into the relapse mechanisms, we analyzed single nucleotide polymorphism arrays for DNA copy number aberrations (CNAs) in 18 matched diagnosis and relapse leukemias. CNAs were more abundant at relapse than at diagnosis (mean 12.5 vs 7.5 per case; P .01) with 5.3 shared on average. Their patterns revealed a direct clonal relationship with exclusively new ab- errations at relapse in only 21.4%, whereas 78.6% shared a common ancestor and subsequently acquired distinct CNA....
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...Employing Microalgae Feedstock for the Production Biodiesel Name: Musfiq Islam UW ID: 20300084 Course: BIOL 443 Professor: Dr. Owen Ward Introduction Global interests in biofuel production as a substitute for liquid transport fuel have grown substantially in recent years, mainly due to concerns over energy security and climate change (Yahya et al, 2012). The most common used biofuels are biodiesel and bio-ethanol, which can replace diesel and gasoline, respectively, with limited or no modifications of vehicle engines (Karthikeya, 2012). These first generation biofuels are typically extracted from food and oil crops including rapeseed oil, sugarcane, sugar beet and corn as well as vegetable oil and animal fats using traditional technologies (Brennan and Owende, 2009). However, the use of first generation biofuels have generated wide-scale criticisms, primarily due to raising competition with food production, increased water consumption, soil degradation, biodiversity loss, their low energy potential and their role in greenhouse gas emissions (Barbosa et al., 2011). A particular concern is that the demand for biofuels could place substantial additional pressure on the natural resources such as arable land. Currently, about 1% (14 million hectares) of the world’s available arable land is used for the production of biofuels, providing 1% of global transport fuels (Beal et al., 2012). However, with a fixed and possibly reducing amount to arable land, increasing the share...
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...aging Only 1 in 8 million have this disease First appearance: Hutchinson(1886) Second appearance: Gilford (1904) Only roughly 60 cases have been reported since: (Debrusk 1972, Brown et al. 1985 & 1986) Erikkson et al. 2003—f rst research done to show actual i causes and effects Research of Erikkson et. al (2003) 1. Out of 23 progeria, he found that 20 had a de novo mutation in LMNA gene(codes for nuclear Lamina A) 2. 18 out of 20: GGCGGT 1 out of 20: GGCAGC 1 out of 20: GAGAAG The causes of Progeria in the other three cases are unknown 3. Creation of splice site Mechanisms of mRNA Splicing Introns vs. Exons Donor acceptor pairs: GT-AG, GC-AG, AT-AC, and GT-GG. (Fong et al. 2006). The base pair progressions, GT, GC, and AT have the potential to set of a splice site. The splice site signals the excision of genetic information, leading to a deletion of 150 bps, and 50 amino acids. Retrieved from: http://progeria2010researchproject.weebly.com/upload s/5/8/7/9/5879933/4698219.png Truncated Lamina A: Progerin Normal Wild-type Lamina contains two modif cations i (attachments): the farsynal group and the terminal group. Removal of two groupssuccessful integration into Nuclear Membrane. Truncated Lamina A (Progerin): does not have terminal group. Cannot successfully integrate, and messes up...
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...Genetics of Homosexuality - Are you Born Gay Name Institution Genetics of Homosexuality - Are you Born Gay Introduction The question as to whether one is born gay or chooses to become so has been a point of debate for a very long time. The present media sources assume that the query is a solved scientific problem with the indication going towards a biological reasoning possibly genetic for a homosexual alignment (Schumm, 2010). Opposing to this idea, the query has been studied poorly, though there are some indications on all sides of the question. Additionally, several studies which were highly flaunted by the media as evidence for the genetic basis for homosexuality have been challenged by the current thorough studies (Diamond, 2006). This proof is considered to fall under five critical categories. These include: * Possible hormone influences * Brain structure * Real genetic studies (GWAS) * Concordance of genomic markers in relations * Concordance of homosexuality in twins Until recently, sexual orientation used to be referred to as sexual preference. Definitely, these two terms represent significant variations in the way in which sexuality matures. A likelihood or preference is a choice of something due to taste while orientation is something that generally defines us (Schumm, 2010). The variations are practically necessary with respect to how legal rules apply to those gay individuals. In case homosexuality is not preferred, but actually is a genetically...
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...bacteria: "I then most always saw, with great wonder, "an unbelievably great there wereof living that in the said matter company many very animalcules, a-swimming more nimbly than little living animalcules, very prettily a-moving. any Ibiggest sort. . . up to this time. The The had ever seen had a very strong and biggest sort. .and shot through into water (or swift motion, . bent their body the curves in going forwards. . . does through the water. The spittle) like a pike Moreover, the other animalcules were in suchspun round numbers, second sort. . . oft-times enormous like a top. that allthese were.far more in number." . . and the water. . seemed to be alive." Modern Cell and Molecular Biology Cytology the study of cell structure Genetics the study of the behavior of genes Biochemistry the study of the chemistry of living systems Cell and Molecular Biology Figure 1-2 Resolving Power of the Human Eye, the Light Microscope, and the Electron Microscope ? The study of cells •1830’s...
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...Animal studies show that both maternal undernutrition and over nutrition reduce placental-fetal blood flows and stunt fetal growth. Impaired placental syntheses of nitric oxide (a major vasodilator and angiogenesis factor) and polyamines (key regulators of DNA and protein synthesis) may provide a unified explanation for intrauterine growth retardation in response to the 2 extremes of nutritional problems with the same pregnancy outcome. There is growing evidence that maternal nutritional status can alter the epigenetic state (stable alterations of gene expression through DNA methylation and histone modifications) of the fetal genome. This may provide a molecular mechanism for the impact of maternal nutrition on both fetal programming and genomic imprinting. Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults. Maternal nutrition plays a critical role in fetal growth and development. Although considerable effort has been directed towards defining nutrient requirements of animals over the past 30 y, suboptimal nutrition during gestation remains a significant problem for many animal species (e.g., cattle, pigs, and sheep) worldwide. Despite advanced...
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...DRUG DEVELOPMENT SCIENCE Obstacles and Opportunities for Collaboration Among Academia, Industry and Government January 13–14, 2005 Washington, DC David Korn, M.D. Donald R. Stanski, M.D. Editors DRUG DEVELOPMENT SCIENCE Obstacles and Opportunities for Collaboration Among Academia, Industry and Government Report of an Invitational Conference Organized by The Association of American Medical Colleges Food and Drug Administration Center for Drug Development Science, at the University of California, San Francisco January 13-14, 2005 Washington, DC David Korn, M.D. Donald R. Stanski, M.D. Editors DRUG DEVELOPMENT SCIENCE ACKNOWLEDGEMENTS This is the report of a conference convened by the Association of American Medical Colleges and the Food and Drug Administration in response to the FDA white paper entitled “Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Product Development”. The conference was partially supported by the FDA. The AAMC acknowledges with gratitude the additional support provided by Abbott Laboratories, Cephalon, Inc., Eli Lilly and Company, GlaxoSmith Kline, Merck & Co. Inc., and Pfizer, Inc. The conference planning committee consisted of Drs. David Korn, Joel Kupersmith, Carl Peck, Donald Stanski, and Janet Woodcock. Figures 1 and 2 are taken from the FDA white paper. The back cover composite is derived from charts presented at the conference by Dr. Peter Corr, Pfizer, Inc. The report was designed by Douglas Ortiz, AAMC...
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...Naturwissenschaften (2004) 91:255–276 DOI 10.1007/s00114-004-0515-y REVIEW Ulrich Kutschera · Karl J. Niklas The modern theory of biological evolution: an expanded synthesis Published online: 17 March 2004 Springer-Verlag 2004 Abstract In 1858, two naturalists, Charles Darwin and Alfred Russel Wallace, independently proposed natural selection as the basic mechanism responsible for the origin of new phenotypic variants and, ultimately, new species. A large body of evidence for this hypothesis was published in Darwin’s Origin of Species one year later, the appearance of which provoked other leading scientists like August Weismann to adopt and amplify Darwin’s perspective. Weismann’s neo-Darwinian theory of evolution was further elaborated, most notably in a series of books by Theodosius Dobzhansky, Ernst Mayr, Julian Huxley and others. In this article we first summarize the history of life on Earth and provide recent evidence demonstrating that Darwin’s dilemma (the apparent missing Precambrian record of life) has been resolved. Next, the historical development and structure of the “modern synthesis” is described within the context of the following topics: paleobiology and rates of evolution, mass extinctions and species selection, macroevolution and punctuated equilibrium, sexual reproduction and recombination, sexual selection and altruism, endosymbiosis and eukaryotic cell evolution, evolutionary developmental biology, phenotypic plasticity, epigenetic inheritance and...
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...“Inappropriate genetic testing can threaten individual autonomy, privacy, and confidentiality and lead to various types of genetic stigmatization and discrimination without any commensurate benefit for the individual tested,” (Brandt; Rauf, 2004). When Burlington Northern Santa Fe Railway (BNSF) tested their employees without the employees knowing about it, the Equal Employment Opportunity Commission (EEOC) stepped in and cited that BNSF violated the employee’s equal rights through discrimination and the employee’s rights of privacy. These actions “raise serious concerns that such testing could pose a significant threat to workers' privacy, autonomy, and dignity. Thus, defining the ethically, legally, and socially appropriate and inappropriate uses of genetic testing in the workplace,” (DEHS, 2001) presents a major breach in a workers legal right to privacy. One hundred and twenty-five BNSF employees filed on-the-job injury claims citing carpal tunnel syndrome (CTS) for “years of repetitive activity such as wielding a wrench or operating a jackhammer,” (Lehrer, 2001; UNK, 2001). While investigating these claims, BNSF medical doctor required further testing of 20 employees (UNK, 2001). The medical company pulled blood for genetic testing without telling the BNSF employees what kind of test that they were performing, (Mahanna, 2001; Schafer, 2001; BNSF, 2002; Lehrer, 2001; Lewin, 2002). One employee refused to submit to the tests and BNSF threatened to terminate his job (Lewin;...
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