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Genom Editing

In:

Submitted By castelli10
Words 646
Pages 3
Michael Castelli
April 23, 2015
CHE 128- Sista
Current Event article
Improving Accuracy in Genome Editing A few years ago science only had the ability to imagine genome editing and all the benefits it could bring to society, however it is now in the works of becoming non-fiction as research has significantly improved. Certain proteins in the body such as Cas9 and CRISPR are responsible for the human genetics and the creation of the immune system. The ability to edit these proteins and change their make up can benefit people with many serious present and future health risks. When speaking on the topic of genetically engineering the human body many challenges arise such as, improving the specificity of the proteins at the rate at which genome-editing proteins modify the target DNA sequence. However, this huge challenge that science has yet to overcome is slowly being resolved by Chemistry Professor David Liu.
Liu and his team have recently used a drug like molecule to create an engineered form of Cas9. Since this development the team is able to control the production of active Cas6 and modify targets in the human genome. "We showed it's possible to achieve efficient genome editing using this system, but because you can stop the production of active Cas9 by withholding the small molecule once it's had enough time to modify the target genes, you limit the opportunity for off-target genome modification." This discovery has raised many question and given science a huge step towards success.
In order to increase the specific genome editing proteins, the proteins must recognize longer genetic sequences, which makes it harder for them to bind with other proteins that are off target. Next, Liu explains the importance of genome editing proteins and how they are not like traditional biochemistry. Genome editing proteins only need to be active for very limited times

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