...At the Intersection of Health, Health Care and Policy Cite this article as: Henry G. Grabowski, Joseph A. DiMasi and Genia Long The Roles Of Patents And Research And Development Incentives In Biopharmaceutical Innovation Health Affairs, 34, no.2 (2015):302-310 doi: 10.1377/hlthaff.2014.1047 The online version of this article, along with updated information and services, is available at: http://content.healthaffairs.org/content/34/2/302.full.html For Reprints, Links & Permissions: http://healthaffairs.org/1340_reprints.php E-mail Alerts : http://content.healthaffairs.org/subscriptions/etoc.dtl To Subscribe: http://content.healthaffairs.org/subscriptions/online.shtml Health Affairs is published monthly by Project HOPE at 7500 Old Georgetown Road, Suite 600, Bethesda, MD 20814-6133. Copyright © 2015 by Project HOPE - The People-to-People Health Foundation. As provided by United States copyright law (Title 17, U.S. Code), no part of Health Affairs may be reproduced, displayed, or transmitted in any form or by any means, electronic or mechanical, including photocopying or by information storage or retrieval systems, without prior written permission from the Publisher. All rights reserved. Not for commercial use or unauthorized distribution Downloaded from content.healthaffairs.org by Health Affairs on February 29, 2016 at UNIV OF CALIFORNIA Intellectual Property & Innovation By Henry G. Grabowski, Joseph A. DiMasi, and Genia Long 10.1377/hlthaff...
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...Abstract: An ongoing project for reconstructing the behavior of the geomagnetic field intensity during the last seven millennia has yielded several new dates for archaeometallurgical sites in the Southern Levant. These dates shed new light on the dawn of metallurgy in the region as well as on the quality of technological development and its relation to social and political structures. This paper introduces the methodology and concepts behind the archaeomagnetic project as well as the principles of the applied dating technique. In addition, the paper presents the archaeomagnetic results, discusses the alternative dating of several archaeometallurgical sites and explores the implication of these results on our understanding of the interaction between technology and society in the past. For the latter, the results particularly challenge the "Standard View of Technology" (Pfaffenberger, 1992), and suggest a complex, nonlinear evolution of copper industry in the Southern Levant eScholarship provides open access, scholarly publishing services to the University of California and delivers a dynamic research platform to scholars worldwide. UNIVERSITY OF CALIFORNIA, SAN DIEGO Technology and Society: Some Insights on the Development of Metallurgy in the Southern Levant in the Light of New Dates of Slag Deposits A Thesis submitted in partial satisfaction of the requirements for the degree Master of Arts in Anthropology by Erez Ben-Yosef...
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...Author of this Work has been asserted in accordance with the UK Copyright, Designs, and Patents Act 1988. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by the UK Copyright, Designs, and Patents Act 1988, without the prior permission of the publisher. First published 2006 by Blackwell Publishing Ltd 1 2006 Library of Congress Cataloging-in-Publication Data Shaffer, Brian W., 1960– Reading the novel in English, 1950–2000 / Brian W. Shaffer. p. cm.—(Reading the novel) Includes bibliographical references and index. ISBN-13: 978-1-4051-0113-4 (hardback : alk. paper)...
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...Introduction As the awareness and adoption of patents grows across the globe, we look to evaluate the consequences to society as a result of protection through patents. We will look at both sides objectively – the side of the inventor who has been granted exclusive rights to his/her invention and the other side – whether patents can deny basic social rights such as health to society. As we move further, we will look to understand a global framework (TRIPS) that provides guidelines on intellectual property regulations, the issue of compulsory licenses used by governments to circumvent patent protection and critically analyze specific cases where issuing compulsory licenses may be the need of the hour. What is TRIPS? TRIPS or Trade Related Aspects of Intellectual Property Rights is an agreement administered by the World Trade Organization (WTO). The agreement covers the following broad issues with respect to regulation of intellectual property (IP): • Basic principles that apply to intellectual property rights agreements • Protection to intellectual property rights • enforcement of intellectual property rights across member nations • settling disputes related to intellectual property rights between member nations A key objective of TRIPS is to provide a common set of international rules or guidelines to ensure protection of patents around the world. TRIPS is unique because it binds any country to its system of intellectual property protection if that country...
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...9-798-062 REV: FEBRUARY 25, 2006 PANKAJ GHEMAWAT JAN W. RIVKIN Creating Competitive Advantage Some companies generate far greater profits than others. The pharmaceutical maker ScheringPlough produced an economic profit of more than $10 billion during the period 1984-2002. That is, the accounting profit it generated exceeded its cost of equity capital by that amount. Over the same period, U.S. Steel produced an economic loss of nearly $500 million; its cost of capital exceeded its accounting profit by a wide margin. Such large differences in economic performance are commonplace. Understanding their roots is crucial for strategists. Differences in industry structure shed some light on such differences in performance. To a certain extent, Schering-Plough has generated more economic profit than U.S. Steel because the pharmaceutical industry is structurally more attractive than the steel industry. Rivalry in the pharmaceutical market is muted by factors such as patent protection, product differentiation, and expanding demand; in contrast, rivalry in the steel industry is fierce—fueled by excess capacity, limited differences across products, and slow growth. Many pharmaceutical users hesitate to switch among products or brands, while steel customers are usually willing to switch among producers to get a better price. Many pharmaceuticals are made from commodities with little labor input, while unions exercise such power in the steel industry that labor costs often account for...
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...ESSAY 3 HEALTH IN THE TROPICS STATE OF THE TROPICS causes of mortality. Improvements in quality of life through improved health are harder to quantify accurately at scale. Life Expectancy Life expectancy is covered in detail elsewhere in the State of the Tropics, and reports that between 1950 and 2010 the gap between life expectancy in the Tropics and the Rest of the World has narrowed. Over this period life expectancy in the Tropics increased by 22.8 years to 64.4 years and infant mortality reduced by 36%. The rate of change of mortality and morbidity has increased over the last two decades influenced by a range of different factors. Underlying life expectancy data are aggregated data, collected by the WHO to document the changing patterns of mortality. Table E3.1 provides the top ten causes of mortality in rank order over the last decade. Non-communicable diseases (NCDs) accounted for two-thirds of global deaths in 2011 and infectious diseases for one-third. In 2000 the relative proportions were 60% NCDs and 40% infectious diseases. This rapid shift reflects the massive scale up in recent efforts to prevent and treat a number of major infectious diseases. Although improvements in maternal and child mortality have been made these still remain unacceptably high. In 2011, 6.9 million children under the age of five died, 99% of these in low and middle income countries. Malaria, despite the enormous scale up in control activities still ...
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...DECEMBER 21, 2012 CORPORATES RATING METHODOLOGY Global Pharmaceutical Industry Summary This rating methodology explains Moody’s approach to assessing credit risk for companies in the pharmaceutical industry globally. This document is intended to provide general guidance that helps companies, investors, and other interested market participants understand how key qualitative and quantitative risk characteristics are likely to affect rating outcomes for companies in the pharmaceutical industry. This document does not include an exhaustive treatment of all factors that are reflected in Moody’s ratings but should enable the reader to understand the qualitative considerations and financial information and ratios that are usually most important for ratings in this sector. This rating methodology replaces 1 the Global Pharmaceutical Industry Methodology published in October 2009. While reflecting many of the same core principles as the 2009 document, this update provides a more transparent presentation of the rating considerations that are usually most important for companies in this sector and incorporates refinements in our analysis that better reflect key credit fundamentals of the industry. No rating changes will result from publication of this rating methodology. This report includes a detailed rating grid and illustrative mapping examples that compare historical performance on factors in the grid to ratings of companies covered by this methodology. The purpose of the...
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.... ìGETTING TO NOî AN ANALYSIS OF FAILED MEDIATION IN THE ISRAELI-PALESTINIAN CONFLICT (1993-2000) Master of Arts in Law and Diplomacy Thesis Submitted by Ahsiya Posner 9 February 2003 Under the advisement of Professor Eileen Babbitt and Professor Diana Chigas ABSTRACT This paper will attempt this difficult but important task with the humble understanding that ìthe full storyî is impossible to know and telló even for the very participants of the process. Nevertheless, in this investigation, the author will explore four main questions. The first three questions are: 1) did the OPP set the Israelis and Palestinians on a trajectory that ìdoomedî CD2 from the start?; 2) were there problems inherent to the process and structure of CD2 that led to its failure?; and, 3) how should future mediation attempts of the Israeli-Palestinian conflict be structured in order to meet with more success? The fourth question, however, requires further introduction. The forthcoming study of CD2 will be guided by a ìProvisional Framework (PF)î of seven criteria that I believe are necessary ingredients to successful peacemaking processes. I devised this framework after consulting existing literature and scholars in the field of mediation and negotiation in general, as well as after reviewing scholarly pieces focusing on the Israel-Palestinian peace process in particular. Thus, after using this framework to analyze CD2, conclusions will thus be drawn with regard to a fourth and final question:...
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...Mechanisms and Corporate Relationships Riitta Katila Stanford University Jeff D. Rosenberger Nomis Solutions Kathleen M. Eisenhardt Stanford University This paper focuses on the tension that firms face between the need for resources from partners and the potentially damaging misappropriation of their own resources by corporate “sharks.” Taking an entrepreneurial lens, we study this tension at tie formation in corporate investment relationships in five U.S. technology-based industries over a 25-year period. Central to our study is the “sharks” dilemma: when do entrepreneurs choose partners with high potential for misappropriation over less risky partners? Our findings show that entrepreneurs take the risk when they need resources that established firms uniquely provide (i.e., financial and manufacturing) and when they have effective defense mechanisms to protect their own resources (i.e., secrecy and timing). Overall, the findings show that tie formation is a negotiation that depends on resource needs, defense mechanisms, and alternative partners. These findings contribute to the recent renaissance of resource dependence theory and to the discussion on the surprising power of entrepreneurial firms in resource mobilization.• A central question in organization and strategy research is how firms gain resources (Penrose, 1959; Thompson, 1967). In response, researchers have identified several approaches, including the acquisition of other firms (Ahuja...
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...What are scientists doing to solve of the problem of HIV? What are scientists doing to solve of the problem of HIV? By Prerana Bhandari St Olaves Grammar School By Prerana Bhandari St Olaves Grammar School Image taken from: http://cdn.zmescience.com/wp-content/uploads/2014/04/hiv_virus.jpg This human T cell (blue) is under attack by HIV (yellow), the virus that causes AIDS. Image taken from: http://cdn.zmescience.com/wp-content/uploads/2014/04/hiv_virus.jpg This human T cell (blue) is under attack by HIV (yellow), the virus that causes AIDS. Page Number: 3 6 8 9 Page Number: 3 6 8 9 Contents: 1. Biological Problem 2. Pathology 3. Solutions for HIV: 4. 14 15 16 18 19 20 21 23 8 9 14 15 16 18 19 20 21 23 8 9 Main Solution: Stribild or Quad study 102 and 103: 5. Evaluation of Stribild: Are the processes and methods appropriate for producing valid and reliable data and effective solutions? 6. How Stribild works 7. Limitations of Stribild 8. Benefits and Risks of Stribild to humans 9. Alternate solutions 10. Conclusion 11. References 12. Evaluation of sources What are scientists doing to solve of the problem of HIV? Biological Problem: HIV (human immunodeficiency virus) is a virus which attacks the immune system, and weakens your ability to fight infections and disease and the final stage of HIV; AIDS (acquired immune deficiency) is when your body can...
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...GlaxoSmithKline company profile Francis Weyzig Amsterdam, October 2004 Summary Business description GlaxoSmithKline (GSK) is one of the world’s largest research-based pharmaceutical corporations that discovers, develops, manufactures and markets branded human health products. Headquarters: UK, with additional operational headquarters in the USA Global presence: about 160 countries Primary markets: USA, France, Germany, UK, Italy and Japan Employees: approximately 103,000 GSK key figures for 2003 (in £ million) Sales 21,441 Materials and production costs 4,188 Marketing and administration 7,563 R&D expenditures 2,770 Operating income 6,920 Net profit 4,765 GSK has two main business divisions, pharmaceuticals and consumer healthcare. This profile deals with the pharmaceuticals division, which generates 85% of GSK’s sales. The five largest selling GSK products are Seretide/Advair for asthma and Chronic Obstructive Pulmonary Disease (COPD); Paxil/Seroxat and Wellbutrin, both antidepression drugs; Avandia/Avadamet for type 2 diabetes; and the antibiotic Augmentin. Each of these drugs generated above £800 million of sales in 2003. GSK produces a broad range of products of special importance to developing countries, including: Anti-malaria drugs Zentel (albendazole), for de-worming and the prevention of lymphatic filariasis Pentosam, against leishmaniasis Anti-retrovirals (ARVs) for the treatment of HIV/AIDS Tuberculosis drugs Vaccines for developing countries Corporate...
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...A PROJECT REPORT ON COMPENSATION MANAGEMENT IN HETERO DRUGS LIMITED SANATHNAGAR, HYDERABAD In partial fulfillment of the requirement for the award of the degree of MASTER OF HUMAN RESOURCE MANAGEMENT Submitted by G.VARALAKSHMI [pic] K.G.R.L.PG COLLEGE, BHIMAVARAM. ANDHRA UNVERISTY VISKAPATANAM (2009-2011) DECLARATION I here by declare that this project report titled a study on “COMPENSATION MANAGEMENT” in HETERO DRUGS LIMITED has been carried out by me Submitted in partial fulfillment of the award of the degree of “ MASTER OF HUMAN RESOURCE MANAGEMENT”, in K.G.R.L .PG COLLEGE BHIMAVARAM. PLACE: DATE: (G.VARALAKSHMI) PREFACE In today’s changing world on should aware of latest trends market demand then only survival can be possible and can compete with others. The concept of “compensation management” plays a significant role in HUMAN RESOURECE MANAGEMENT. COMPENSATION MANAGEMENT is defined as “ systematic approach to provide monetary value to employee in exchange of work performed” A study has been conducted on “COMPANSATION MANAGEMENT” and a Questionnaire is prepared to conduct survey to know how it is working in “HETERO DRUGS LIMITED”. A through analysis is presented in this report on the study conducted with the help of graphical representation. ACKNOWLEDGEMENT I take the opportunity to express...
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...Media History Contents 1 Introduction 1.1 Mass media . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.1 1.1.2 1.1.3 1.1.4 1.1.5 1.1.6 1.1.7 1.1.8 1.1.9 Issues with definition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Forms of mass media . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Purposes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Professions involving mass media . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Influence and sociology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Ethical issues and criticism . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Future . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . See also . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1 1 2 6 6 7 8 10 10 10 10 11 11 12 12 12 12 16 16 17 17 17 17 17 17 18 19 20 21 21 21 1.1.10 Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.11 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.12 Further reading . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1.1.13 External links . . . . . . . . ....
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...Business Administration Toronto, Ontario, Canada, 2009 © Cecile Oger 2009 Library and Archives Canada Bibliothèque et Archives Canada Published Heritage Branch Direction du Patrimoine de l’édition 395 Wellington Street Ottawa ON K1A 0N4 Canada 395, rue Wellington Ottawa ON K1A 0N4 Canada Your file Votre référence ISBN: 978-0-494-59035-5 Our file Notre référence ISBN: 978-0-494-59035-5 NOTICE: AVIS: The author has granted a nonexclusive license allowing Library and Archives Canada to reproduce, publish, archive, preserve, conserve, communicate to the public by telecommunication or on the Internet, loan, distribute and sell theses worldwide, for commercial or noncommercial purposes, in microform, paper, electronic and/or any other formats. . The author retains copyright ownership and moral rights in this thesis. Neither the thesis nor substantial extracts from it may be printed or otherwise reproduced without the author’s permission. L’auteur a accordé une licence non exclusive permettant à la Bibliothèque et Archives Canada de reproduire, publier, archiver, sauvegarder, conserver, transmettre au public par télécommunication ou par l’Internet, prêter, distribuer et vendre des thèses partout dans le monde, à des fins commerciales ou autres, sur support microforme, papier, électronique et/ou autres formats. L’auteur conserve la propriété du droit d’auteur et des droits moraux qui protège cette thèse. Ni la thèse ni...
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...SOLUTION-FOCUSED PASTORAL COUNSELING FINAL PROJECT By Marlinda M. House Rhodes Student ID #: 25149472 Presented to Dr. Max Grayson Mills In partial fulfillment of the requirements of Introduction to Pastoral Counseling PACO 500 Liberty Baptist Theological Seminary Lynchburg, VA August 18, 2012 TABLE OF CONTENTS ABSTRACT……………………………………………………………………………………..3 PART 1: THE COUNSELING SETTING Solution-Focused Pastoral Counseling Preference…………………………………....4 PART 2: THE COUNSELING STYLE Rational of Style and Assessments……………………………………………………….5 Overview Check and Balance………………………………………………………....6 PART 3: The Counseling Structure Strategy Phase 1 The Event…………………………………………………………………....7 Phase 2 Preferred Solutions………………………………………………………….….8 Phase 3 The Path to Change……………………………………………………….…9 Phase 4 Covenants for Success …………………………………………………………9 PART 4: Counseling Summation Supportive Approach ……………………………………………………………..10 ...
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