...Lupus, Latin for wolf, is the word used historically to describe any chronic, usually ulcerating, skin disease. Dr. Max Gerson's rise to medical prominence in pre-WWII Germany was owed to the curative effect in lupus vulgaris of a salt-free diet bearing his name. Lupus vulgaris, a European plague of the early part of this century, was tuberculosis of the skin, a bacterial disease that has been largely eliminated through improved public health measures and, to a lesser extent, by antibacterial drugs. Today's lupus is systemic lupus erythematosus (SLE), an inflammatory disorder of connective tissue which frequently targets skin (hence the designation lupus) as well as joints, kidneys, mucous membranes, the nervous system, and virtually any other organ or system in the body. Onset of the disease may be sudden and acute, with fever, painful and swollen joints, skin rash, and influenza-like symptoms; or it may smolder for years with low level malaise and intermittent fevers. Symptoms The list of symptoms attributable to SLE is extensive and astonishing. Among symptoms most frequently observed are painful joints, usually of the hands and feet, which may also include the larger joints. Of all SLE patients, 92% endure significant joint pain. Similarly, 84% of all SLE patients suffer from fevers. Skin eruptions, including round or discoid lesions, as well as a butterfly rash presenting on the cheeks below the eyes and bridging the nose, will afflict 72%. Inflammatory kidney dysfunctions...
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...1.2 INTRODUCTION TO BIOMATERIALS There is a necessity for replacing bone substance which has been lost due to traumatic or nontraumatic events. The lost bone can be replaced by endogenous or exogenous bone tissues, which is connected with several problems. The use of endogenous bone substance involves additional surgery; moreover the endogenous bone is available only in limited quantities. In case of exogeneous bone implants, the major disadvantage is that they may be rejected by human body, disease may be transmitted together with the implant, and also the clinical performance of exogenous bone is considerably inferior to fresh endogenous graft material. For these reasons there is growing need for fabrication of artificial hard tissue replacement implants. Research into novel materials for biomedical applications is ever increasing as the medical community look to improve the way in which disorders and trauma are treated. Issues with current materials and the additional trauma associated with the use of bone grafts has pushed research towards new materials to aid the required repair and/or the regeneration of bone after fracture or the removal of bony defects or cancerous bone. Many new materials have been developed in an attempt to address these concerns but there are still some issues surrounding the appropriateness of their mechanical properties, the ability of degradable materials to retain their properties once implanted and the ability to form the material in situ...
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...European Medicines Agency Evaluation of Medicines for Human Use Doc.Ref:EMEA/501324/2008 ASSESSMENT REPORT FOR FILGRASTIM RATIOPHARM International Nonproprietary Name: filgrastim Procedure No. EMEA/H/C/824 Assessment Report as adopted by the CHMP with all information of a commercially confidential nature deleted. 7 Westferry Circus, Canary Wharf, London E14 4HB, UK Tel. (44-20) 74 18 84 00 Fax (44-20) 74 18 84 16 E-mail: mail@emea.europa.eu http://www.emea.europa.eu © European Medicines Agency, 2008. Reproduction is authorised provided the source is acknowledged. TABLE OF CONTENTS 1 BACKGROUND INFORMATION ON THE PROCEDURE................................................... 3 1.1 Submission of the dossier ...................................................................................................... 3 1.2 Steps taken for the assessment of the product........................................................................ 3 2 SCIENTIFIC DISCUSSION......................................................................................................... 5 2.1 Introduction............................................................................................................................ 5 2.2 Quality aspects ....................................................................................................................... 5 2.3 Non-clinical aspects ..................................................................................................
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...Medicine, Centro per lo Studio e la Cura della Malattia Celiaca, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, University of Pavia, Pavia, Italy Enteropathy-associated T-cell lymphoma (EATL) is a complication of celiac disease (CD). This tumor derives from the neoplastic transformation of aberrant intraepithelial T lymphocytes emerging in celiac patients unresponsive to a gluten-free diet. Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD. Recurrence of diarrhea, unexplained weight loss, abdominal pain, fever, and night sweating should alert physicians to this complication. The suspicion of EATL should lead to an extensive diagnostic workup in which magnetic resonance enteroclysis, positron emission tomography scan, and histologic identification of lesions represent the best options. Treatment includes high-dose chemotherapy preceded by surgical resection and followed by autologous stem cell transplantation, although biologic therapies seem to be promising. Strict adherence to a gluten-free diet remains the only way to prevent EATL. (Blood. 2012;119(11): 2458-2468) Introduction Celiac disease (CD) is a chronic gluten-sensitive enteropathy characterized by a high prevalence in the general population and an increased mortality.1,2 It is well known that the increased mortality is mainly the result of the complications of CD itself, represented by...
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...When it comes to understanding animals and the diseases they have, contract, and carry there is no limits. From dogs and cats to livestock and exotics it is necessary to learn and understand diseases from metabolic to degenerative or idiopathic, Neoplastic diseases and Toxic poisonings, Congenital and Genetic diseases to Immune related diseases, and Infectious and Contagious diseases to Parasitic Infections. There is a world that one can get lost in when it comes to learning about theses things. Some diseases have been around for years while others are still being studied with new ones occurring today in the modern world. Along with these diseases it is important to study and understand what causes them, what signs to look for, what species to look for them in, how to treat them, and how to prevent them from happening, IF you can even prevent them. Some diseases and conditions have vaccines to help with prevention and some do not, while some diseases are zoonotic meaning that they can be transmitted from animal to human. While there are hundreds upon hundreds of diseases to be looked at, the ten researched below are the ones once prevalent among the veterinary technicians job in the clinic; Hip Dysplasia and Ethylene Glycol poisoning in dogs, Hyperthyroidism and Rabies in cats, Strangles and Equine Recurrent Uveitits in Horses, Cryptosporidium and Fasciola Hepatica in Ruminants and Swine, Idiopathic Epilepsy in Aviaries, and Lymphoma in Ferrets. Hip Dysplasia in dogs is a congenial...
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...geriatric medicine. As a physician you will be faced daily with the concepts of microbial disease and antimicrobial therapy. Microbiology is one of the few courses where much of the "minutia" is regularly used by the practicing physician. This book attempts to facilitate the learning of microbiology by presenting the information in a clear and entertaining manner brimming with memory aids. Our approach has been to: 4) Create a conceptual, organized approach to the organisms studied so the student relies less on memory and more on logical pathophysiology. The text has been updated to include current information on rapidly developing topics, such as HIV and AIDS (vaccine efforts and all the new anti-HIV medications), Ebola virus, Hantavirus, E. coli outbreaks, Mad Cow Disease, and brand-new antimicrobial antibiotics. The mnemonics and cartoons in this book do not intend disrespect for any particular patient population or racial or ethnic group but are solely presented as memory devices to assist in the learning of a complex and important medical subject. We welcome suggestions for future editions. 1) Write in a conversational style for rapid assimilation. 2) Include numerous figures serving as "visual memory tools" and summary charts at the end of each chapter. These can be used for "cram sessions" after the concepts have been studied in the text. 3) Concentrate more on clinical and infectious disease issues that are both interesting and vital to the actual practice of medicine. MARK...
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...Physiology of Blood Components, Characteristics, Functions of Blood Major Components of Blood 1. Formed elements - the actual cellular components of blood (special connective tissue) a.erythrocytes - red blood cells b.leukocytes - white blood cells c.platelets - cell fragments for clotting 2. Blood plasma - complex non-cellular fluid surrounding formed elements; protein & electrolytes. Separation of Components in a Centrifuge VOLUME LAYER clear/yellowish PLASMA 55% top thin/whitish buffy coat proerythroblast ->early (basophilic) erythroblast ->late (polychromatophilic) erythroblast ->(hemoglobin) normoblast -> (nucleus ejected when enough hemoglobin)reticulocyte -> (retaining some endoplasmic reticulum) ERYTHROCYTE life span: hemocytoblast -> reticulocyte 3-5 DAYS reticulocyte -> ERYTHROCYTE 2 DAYS (in blood) ERYTHROCYTE lifespan 100-120 DAYS (primarily destroyed by macrophages in the spleen) 3. Regulation of Erythropoiesis a. hormonal controls - erythropoietin is the hormone that stimulates RBC production DECREASED oxygen level in blood causes KIDNEYS to increase release of erythropoietin 1. Less RBCs from bleeding 2. Less RBCs from excess RBC destruction 3. Low oxygen levels (high altitude, illness) ...
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...A kid with Hepatitis A can return to school 1 week within the onset of jaundice. 2. After a patient has dialysis they may have a slight fever...this is normal due to the fact that the dialysis solution is warmed by the machine. 3. Hyperkalemia presents on an EKG as tall peaked T-waves 4. The antidote for Mag Sulfate toxicity is ---Calcium Gluconate 5. Impetigo is a CONTAGEOUS skin disorder and the person needs to wash ALL linens and dishes seperate from the family. They also need to wash their hands frequently and avoid contact. positive sweat test. indicative of cystic fibrosis 1. Herbs: Black Cohosh is used to treat menopausal symptoms. When taken with an antihypertensive, it may cause hypotension. Licorice can increase potassium loss and may cause dig toxicity. 2. With acute appendicitis, expect to see pain first then nausea and vomiting. With gastroenitis, you will see nausea and vomiting first then pain. 3. If a patient is allergic to latex, they should avoid apricots, cherries, grapes, kiwi, passion fruit, bananas, avocados, chestnuts, tomatoes and peaches. 4. Do not elevate the stump after an AKA after the first 24 hours, as this may cause flexion contracture. 5. Beta Blockers and ACEI are less effective in African Americans than Caucasians. 1. for the myelogram postop positions. water based dye (lighter) bed elevated. oil based dye heavier bed flat. 2.autonomic dysreflexia- elevated bed first....then check foley...
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...Confirming Pages bye80180_appB_539-654.qxd 11/19/09 9:17 AM Page 539 technology ventures - management dell’imprenditorialità e dell’innovazione Richard C. Dorf, Andrew J. Nelson, Roberto Vona Copyright © 2011 – The McGraw-Hill Companies srl A P P E N D I X B Cases 539 bye80180_appB_539-654.qxd 11/19/09 9:17 AM Page 540 Confirming Pages technology ventures - management dell’imprenditorialità e dell’innovazione Richard C. Dorf, Andrew J. Nelson, Roberto Vona Copyright © 2011 – The McGraw-Hill Companies srl 540 APPENDIX B Cases TREXEL We’ve never met a customer who wasn’t interested in our technology. —David Bernstein, CEO of Trexel David Bernstein hung up the phone with Alex d’Arbeloff, Trexel’s largest investor, and contemplated an upcoming Board of Directors meeting scheduled for June 25, 1998. The meeting was only 10 weeks away and Bernstein, Trexel’s president and chief executive officer, needed to present a coherent vision of the company’s new strategy. Bernstein believed that Trexel’s patented technology for manufacturing foamed plastics had the potential to revolutionize much of the worldwide plastics industry. His innovative process technology, known as MuCell, allowed the Woburn, Massachusetts company to produce foamed plastic utilizing 25% to 50% less material than traditional solid plastics without a significant decrease in the strength of the plastic. Bernstein believed the market for products produced via this...
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...Strengthening the Ombudsman Institution in Asia Improving Accountability in Public Service Delivery through the Ombudsman About the Asian Development Bank ADB’s vision is an Asia and Pacific region free of poverty. Its mission is to help its developing member countries reduce poverty and improve the quality of life of their people. Despite the region’s many successes, it remains home to two-thirds of the world’s poor: 1.8 billion people who live on less than $2 a day, with 903 million struggling on less than $1.25 a day. ADB is committed to reducing poverty through inclusive economic growth, environmentally sustainable growth, and regional integration. Based in Manila, ADB is owned by 67 members, including 48 from the region. Its main instruments for helping its developing member countries are policy dialogue, loans, equity investments, guarantees, grants, and technical assistance. Strengthening the Ombudsman Institution in Asia Accountability is essential for good governance, and in many Asian countries the ombudsman is the key accountability institution. Originating in the West, the concept of the ombudsman arrived relatively late in Asia. Yet more and more ombudsman offices are being established in Asia, and they play a critical role in the fight against incompetence and injustice on the part of government officials. This report presents in-depth research on Asian ombudsmen, with a focus on best practices and emerging issues, especially in the context...
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...ARTIFICIAL NEURAL NETWORKS METHODOLOGICAL ADVANCES AND BIOMEDICAL APPLICATIONS Edited by Kenji Suzuki Artificial Neural Networks - Methodological Advances and Biomedical Applications Edited by Kenji Suzuki Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution 3.0 license, which permits to copy, distribute, transmit, and adapt the work in any medium, so long as the original work is properly cited. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Ivana Lorkovic Technical Editor Teodora Smiljanic Cover Designer Martina Sirotic Image Copyright Bruce Rolff, 2010. Used under license from Shutterstock.com First published March, 2011 Printed in...
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...………………………………………………………………..26 4.4 Conclusions and Recommendations…..……………………………………………………………………………….28 5. Summary and Conclusions…………………………………………………………………………………………………………….30 6. Acknowledgements……………………………………………………………………………………………………………………….32 7. References…………………………………………………………………………………………………………………………………….33 Appendices A1 Selection of Key Institutes A2 Results Patent Analysis A3 Research Profiles 1. Introduction This report analyzes the R&D infrastructure in the United States in the field of new medical devices. It is part of the Innovative Medical Devices Initiative the Netherlands (IMDI.NL) thematic program that aims to focus the Netherlands’ R&D infrastructure for medical devices on health care demands and economic growth (1). The study is a collaboration...
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...Unit I Foreign Policy What is Foreign Policy? Foreign policy has many exegesis as there are internationalist who attempt to define this most intriguing subject of international relations. Initially, it has been define as a “ statement of national goals limited both absolutely and relatively by national power”. The Foreign Service Institute of the Philippines prefers to allude to it as “ set of guidelines articulated by the government to a country in order to promote its national interest through the conduct of its relations with other countries” The Foreign Service Institute of the Philippines has likewise quoted a dictum ascribed to President Ferdinand E. Marcos that: The foreign policy of a nation is the articulation of its fondest needs and aspiration, and in international affairs, it is its sole weapon for the promotion of national interest. Foreign Policy is a “part of the general program of government. It is furthermore an extension of its domestic policy”. The term “system” when used in the context of an organization, implies an entity composed of a set of parts and created to accomplish certain, objectives. The aim of the system is the coordination of human efforts and material resources to produce desired results in a dynamic organization. An organization, as social system, has certain inherent characteristics: 1) it has subsystem and, is part of a suprasystem in continual interaction with one another 2) It has define objectives...
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...NaNotechNology applicatioNs for cleaN Water Micro & NaNo TechNologies series editor: Jeremy ramsden Professor of Nanotechnology Microsystems and Nanotechnology Centre, Department of Materials Cranfield University, United Kingdom the aim of this book series is to disseminate the latest developments in small scale technologies with a particular emphasis on accessible and practical content. these books will appeal to engineers from industry, academia and government sectors. for more information about the book series and new book proposals please contact the publisher, Dr. Nigel hollingworth at nhollingworth@williamandrew.com. http://www.williamandrew.com/MNt NaNotechNology applicatioNs for cleaN Water edited by Nora savage Office of Research and Development, US Environmental Protection Agency and (in alphabetical order) Mamadou Diallo Materials and process simulation center, Division of chemistry and chemical engineering, california institute of technology Jeremiah Duncan Nanoscale Science and Engineering Center, University of Wisconsin-Madison anita street Office of Research and Development, US Environmental Protection Agency and Center of Advanced Materials for the Purification of Water with Systems, University of Illinois at Urbana-Champaign richard sustich N o r w i c h , N Y, U S A copyright © 2009 by William andrew inc. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying...
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...ate Aptitude Test in Engineering GATE 2014 Brochure Table of Contents 1. Introduction .............................................................................................................1 2. About GATE 2014 ......................................................................................................1 2.1. Financial Assistance ............................................................................................................................ 1 2.2 Employment ............................................................................................................................................ 2 2.3 Administration ....................................................................................................................................... 2 3.1 Changes Introduced in GATE 2013 that will continue to remain in force for GATE 2014 .......................................................................................................................................................... 3 4.1 Eligibility for GATE 2014 ................................................................................................................... 4 4.2 GATE Papers ............................................................................................................................................ 5 4.3 Zone-Wise List of Cities in which GATE 2014 will be Held ................................................... 6 4.4 Zone-Wise List of Cities for 3rd...
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