...Cell Membranes Exchange The Gas Exchange System Lung Diseases The Heart Coronary Heart Disease The Digestive System Cholera Lifestyle and Disease Defence against Disease Immunisation Monoclonal Antibodies 1 – Mathematical Requirements 2– The Unit 1 Exam 2 4 6 8 10 16 17 24 28 30 31 35 37 44 46 50 54 58 60 67 68 72 80 81 83 86 Cells Human Physiology Disease Appendices These notes may be used freely by A level biology students and teachers, and they may be copied and edited. Please do not use these materials for commercial purposes. I would be interested to hear of any comments and corrections. Neil C Millar (nmillar@ntlworld.co.uk) Head of Biology, Heckmondwike Grammar School High Street, Heckmondwike, WF16 0AH July 2011 HGS Biology A-level notes NCM/7/11 AS Biology Unit 1 page 2 Biology Unit 1 Specification Biochemistry Biological Molecules Biological molecules such as carbohydrates and proteins are often polymers and are based on a small number of chemical elements. • Proteins have a variety of functions within all living organisms. The general structure of an amino acid. Condensation and the formation of peptide bonds linking together amino acids to form polypeptides. The relationship between primary, secondary, tertiary and quaternary structure, and protein function. • Monosaccharides are the basic molecular units (monomers) of which carbohydrates are composed. The structure of α-glucose and the linking of αglucose by glycosidic bonds formed...
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...Chapter 1 Nursing Images throughout History 1) The angle of mercy 2) The handmaiden 3) The battle-ax 4) The naughty nurse 5) The military image A. Nurses on the battlefield * Hospitalers – specialized soldiers who at the end of battle returned to the outposts to care for the sick and injured * Army nursing service – organize nurses and hospitals and coordinate supplies for the soldiers during the Civil War * Clara Barton a. Provided care in tents set up close to the fighting b. Did not discriminate c. Establishment of the American Red Cross * Harriet Tubman – helped slaves escape to freedom on the underground railroad * Walt Whitman – a poet * Louisa May Alcott – an author * Dorothea Dix – union’s superintendent of female nurses during the Civil War B. Nurses fighting diseases * Florence Nightingale d. Epidemiology – the study of the distribution and origins of disease e. Air, light, nutrition, and adequate ventilation and space assist the patient to recuperate * Lillian Wald & Mary Brewster f. Founded the Henry Street Settlement in NY to improve the health and social conditions of poor immigrants g. Improve health and prevent illness by promoting safe drinking water, adequate sewage facilities, and proper sanitation Florence Nightingale (1820-1910) ...
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...EXPERIMENT 1 DETERMINATION OF DISSOLVED OXYGEN IN WATER INTRODUCTION The dissolved oxygen content is an important index when considering its suitability for town supply. A good clean potable water will give dissolved oxygen value close to the theoretical value for the saturated solution of oxygen in water. When there is pollution from organic matter and other trade effluents, the dissolved oxygen is up in various biochemical oxidation processes and its is only slowly replaced through surface absorption. Such water will give a low dissolved oxygen content until oxidation is completed. Adequate dissolved oxygen is necessary for the life of fish and other aquatic organisms. The methods described below for the determination of oxygen in water is based on that devised by Winkler. When manganese hydroxide is precipitated in the water sample it is quickly oxidized to higher hydrated oxides (probably in the four valent state) by the dissolve oxygen. Iodine, equivalent to the dissolved oxygen content, is then liberated on acidification in the presence of iodine, and it may be titrated with standard thio‐sulphate. INTERFERENCES AND PRE – TREATMENT Most oxidising and reducing substances e.g dissolved organic substances, nitrite ions, higher‐valency manganese compounds, active chlorine, sulphide and sulphite ions, iron (II) and irons interfere. The influence of the dissolved organic substances can be excluded by conversion of the manganese hydroxides...
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...Quality of Red Blood Cells Isolated from Umbilical Cord Blood Stored at Room Temperature Mariia Zhurova, 1 John Akabutu, 2 and Jason Acker 3 ,* Author information ► Article notes ► Copyright and License information ► ------------------------------------------------- Abstract Red blood cells (RBCs) from cord blood contain fetal hemoglobin that is predominant in newborns and, therefore, may be more appropriate for neonatal transfusions than currently transfused adult RBCs. Post-collection, cord blood can be stored at room temperature for several days before it is processed for stem cells isolation, with little known about how these conditions affect currently discarded RBCs. The present study examined the effect of the duration cord blood spent at room temperature and other cord blood characteristics on cord RBC quality. RBCs were tested immediately after their isolation from cord blood using a broad panel of quality assays. No significant decrease in cord RBC quality was observed during the first 65 hours of storage at room temperature. The ratio of cord blood to anticoagulant was associated with RBC quality and needs to be optimized in future. This knowledge will assist in future development of cord RBC transfusion product. Go to: ------------------------------------------------- 1. Introduction Fetal and neonatal anemias are among the most serious complications of pregnancy and postnatal development. The causes of fetal anemia include immune haemolytic disease [1],...
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...Surgical Patient Case One: Activity One: With reference to anatomy explain how a gall stone can migrate into the pancreas, causing pancreatitis. The pancreas is in the upper abdomen and lies behind the stomach and intestines. It makes a fluid that contains enzymes that are needed to digest food. The enzymes are made in the pancreatic cells and are passed into tiny tubes. These tubes join together to form the main pancreatic duct. This drains the enzyme-rich fluid into the duodenum. The enzymes are in an inactive form in the pancreas, they are 'activated' in the duodenum to digest food. Groups of special cells called 'Islets of Langerhans' are scattered throughout the pancreas. These cells make the hormones insulin and glucagon. The hormones are secreted directly into the bloodstream to control the blood sugar level. The bile duct carries bile from the liver and gallbladder. This joins the pancreatic duct just before it opens into the duodenum. Bile also passes into the duodenum and helps to digest food. Pancreatitis occurs when the pancreas becomes inflamed. When pancreatitis occurs, it's largely due to digestive enzymes attacking and digesting the pancreas, which produced them in the first place. There are two types of pancreatitis: Acute pancreatitis - when the inflammation develops quickly, over a few days or so. It often goes away completely and leaves no permanent damage. Sometimes it is serious. Chronic pancreatitis - when the inflammation is persistent...
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...Cardiovascular Case Study Mr. Smith is a 56-year-old Caucasian man who is being evaluated in the emergency room with progressively worsening chest pain that began 2 hours ago. The patient describes the pain as pressure in the center of his chest. He rates his pain 7/10. He reports the pain is now radiating down his left arm and through to his back, he is diaphoretic, and complaining of shortness of breath. He denies nausea or vomiting. Mr. Smith reports no previous history of chest pain or pressure. He smoked one pack of cigarettes daily for 13 years but quit smoking last year. He denies a family history of heart disease. Upon initial examination he did not have jugular venous distension, no carotid bruits, normal S1 and S2 with an S3 present. No S4 or murmurs auscultated. Lung sounds clear to auscultation bilaterally, bowel sounds normal, all pulses palpable 2+/4, no edema present. Diagnostic data: BP: 165/98 mmHG HR: 96 bpm RR: 30 breaths/min Temp: 37 C SaO2: 96% with 2L/min O2 per nasal cannula Wt:100 kg A 12-lead ECG was performed in the emergency room showed: Normal Sinus Rhythm (NSR) with frequent premature ventricular contractions. ST segment elevation in Leads 1, aVL, and V2 through V6 (3mm). ST segment depression in Leads III and aVF. Q waves in V2 through V4. The chest X-ray revealed slight cardiomegaly with mild congestive heart failure. An echocardiogram reveals an ejection fraction of 30% and mild mitral valve regurgitation. Mr. Smith’s...
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...Maria Vasilenko 223901 Feasibility of using biosensors for heavy metal detection in complex matrices such as bio-slurries. Master of Science Thesis Examiners: Professor Matti Karp Professor Raghida Lepistö Examiner and topic approved in The Science and Bioengineering Department Council meeting on 7.11.2012 Abstract TAMPERE UNIVERSITY OF TECHNOLOGY Master‟s Degree Programme in Science and Bioengineering Vasilenko Maria: Feasibility of using biosensors for heavy metal detection in complex matrices such as bio-slurries. Seminar paper, 97 pages November 2012 Major: Biotechnology Examiners: Matti Karp, Raghida Lepisto Keywords: environmental pollution, heavy metals, biosensors, slurries The quality of bioslurries that are used in industrial production and agriculture need to be watched very closely to avoid spreading of contaminants on area and poisoning of humans and animals. Because heavy metals are very stable and toxic in many chemical compositions, their amount should be estimated very thoroughly. A new approach that involved biosensors was tested in this study. Because the slurries are complex non-unified matrices which composed of two phases – solid and liquid, the cell behavior can varies a lot from the one that explained in water and so the estimation of ion concentration can be not reliable. It was shown that the cell actually behave different in the slurries. Normally the dissolved compounds suppress the biosensor activity and, in the same time, the ions in the...
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...paper, leaving the residue on the impermeable substance/filtrating medium and the filtrate to pass through. | Dissolved solids in liquids Evaporation | If the liquid in the mixture is more volatile (boiling point is lower) than the soluble solid, the soluble solid will remain while the liquid evaporates. The procedure employs the use of an evaporating dish and a Bunsen burner. | Crystallisation | Another method of dissolved solids from a liquid mixture (solution)The impure salt is dissolved in water at a high temperature to create a concentrated solution.The mixture is then cooled and the salt crystallises, leaving the impurity in the solution.This crystallised slat contains much less of the impurity than before. The salt can then be filtered and dried.Sugar cane industry. | Assess separation techniques for their suitability in separating examples of earth materials, identifying the differences in properties which enable these separations Yes, fractional distillation can separate a mixture of oxygen and nitrogen because they have similar (but not the same) boiling points. Could filtration successfully separate sand from a sand-salt mixture? No. Without water the salts in the sand and salt mixture will not separate out via filtration because filtration requires an insoluble solid plus a liquid mixture, which in this case would be salt + water Describe situations in which gravimetric analysis supplies useful data for chemists and other scientists * the process...
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...Based upon how the patient presented and the results of the diagnostic tests that were conducted the patient was admitted to the progressive care unit of Banner Thunderbird. Diagnostic tests that were conducted was a chest X-ray, magnetic resonance imaging (MRI), and ultra sound to determine if there is a build up or either fluid and/or air in the pleural spaces of the lungs or a tumor that is causing the patient to have difficulty breathing. Non-imaging tests that are conducted would be a blood studies and arterial blood gas test. The blood studies would be able to dictate if the patient has a bacterial or viral infection, pneumonia, rheumatic fever, a pulmonary embolus, or lupus, and the arterial blood gas test will be able to show how well the lungs are taking in oxygen by measuring oxygen and carbon dioxide within the arterial blood that is drawn (Pagana & Pagana, 2010). After collecting the patients medical history, and the results of all the diagnostic tests that were conducted it was determined that the patient had air and fluid accumulation in the pleural spaces in the lungs and needed to have a ultrasound guided thorocentesis to collect a sample of...
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...NAME OF DRUG: Citalopram GENERIC NAME: Citalopram TRADE NAME: Celexa NORMAL DOSAGE & ROUTE: PO: (Adults) 20 mg once daily initially, may be ↑ in 1 wk to 40 mg/day CLASSIFICATION: T her. Class. antidepressants Pharm. Class. selective serotonin reuptake inhibitors ssris ACTION: Selectively inhibits the reuptake of serotonin in the CNS. THERAPEUTIC EFFECT: Antidepressant action. INDICATIONS: Depression CONTRAINDICATIONS: ● Hypersensitivity; ● Concurrent use of MAO inhibitors or MAOlike drugs (linezolid or methylene blue); ● Concurrent use of pimozide; ● Congenital long QT syndrome, bradycardia, hypokalemia, hypomagnesemia, recent myocardial infarction, decompensated heart failure (↑ risk of QT interval prolongation); ● Concurrent use of QT interval prolonging drugs SIDE/ADVERSE EFFECTS: CNS: NEUROLEPTIC MALIGNANT SYNDROME UICIDAL THOUGHTS pathy onfusionrowsiness , S , a , c , d , insomnia , weakness , agitation, amnesia, anxiety, ↓ libido, dizziness, fatigue, impaired concentration, ↑ depression, migraine headache EENT: abnormal accommodation Resp: cough CV: TORSADE DE POINTES , postural hypotension, QT interval prolongation, tachycardia GI: abdominal pain norexia iarrhea ry mouth yspepsialatulence saliva ausea , a , d , d , d , f , ↑ , n , altered taste, ↑ appetite, vomiting GU: amenorrhea, dysmenorrhea, ejaculatory delay, erectile dysfunction, polyuria Derm: sweating...
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...Courtesy of L E K A R SPECIAL EDITION Authors: Marino, Paul L. Title: ICU Book, The, 3rd Edition Copyright ©2007 Lippincott Williams & Wilkins ISBN: 0-7817-4802-X Authors Dedication Quote Preface to Third Edition Preface to First Edition Acknowledgments Table of Contents Section I - Basic Science Review Basic Science Review Chapter 1 - Circulatory Blood Flow Chapter 2 - Oxygen and Carbon Dioxide Transport Section II - Preventive Practices in the Critically Ill Preventive Practices in the Critically Ill Chapter 3 - Infection Control in the ICU Chapter 4 - Alimentary Prophylaxis Chapter 5 - Venous Thromboembolism Section III - Vascular Access Vascular Access Chapter 6 - Establishing Venous Access Chapter 7 - The Indwelling Vascular Catheter Section IV - Hemodynamic Monitoring Hemodynamic Monitoring Chapter 8 - Arterial Blood Pressure Chapter 9 - The Pulmonary Artery Catheter Chapter 10 - Central Venous Pressure and Wedge Pressure Chapter 11 - Tissue Oxygenation Section V - Disorders of Circulatory Flow Disorders of Circulatory Flow Chapter 12 - Hemorrhage and Hypovolemia Chapter 13 - Colloid and Crystalloid Resuscitation Chapter 14 - Acute Heart Failure Syndromes Chapter 15 - Cardiac Arrest Chapter 16 - Hemodynamic Drug Infusions Section VI - Critical Care Cardiology Critical Care Cardiology Chapter 17 - Early Management of Acute Coronary Syndromes Chapter 18 - Tachyarrhythmias Section VII - Acute Respiratory Failure Acute Respiratory Failure Chapter 19 - Hypoxemia...
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...SECOND EDITION ELECTROCHEMICAL METHODS Fundamentals and Applications Allen J. Bard Larry R. Faulkner Department of Chemistry and Biochemistry University of Texas at Austin JOHN WILEY & SONS, INC. New Yorke Chichester • Weinheim Brisbane e Singapore e Toronto Acquisitions Editor David Harris Senior Production Editor Elizabeth Swain Senior Marketing Manager Charity Robey Illustration Editor Eugene Aiello This book was set in 10/12 Times Roman by University Graphics and printed and bound by Hamilton. The cover was printed by Phoenix. This book is printed on acid-free paper, oo Copyright 2001 © John Wiley & Sons, Inc. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning or otherwise, except as permitted under Sections 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 605 Third Avenue, New York, NY 10158-0012, (212) 850-6011, fax (212) 850-6008, E-Mail: PERMREQ@WILEY.COM. To order books or for customer service, call 1 (800)-CALL-WILEY (225-5945). Library of Congress Cataloging...
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...third most common cause of transfusion-associated death. TRALI is defined as noncardiogenic pulmonary edema temporally related to transfusion therapy. The diagnosis of TRALI relies on excluding other diagnoses such as sepsis, volume overload, and cardiogenic pulmonary edema. Supportive diagnostic evidence includes identifying neutrophil or human leukocyte antigen (HLA) antibodies in the donor or recipient plasma. All plasma-containing blood products have been implicated in TRALI, with the majority of cases linked to whole blood, packed RBCs, platelets, and fresh-frozen plasma. The pathogenesis of TRALI may be explained by a “two-hit” hypothesis, with the first “hit” being a predisposing inflammatory condition commonly present in the operating room or ICU. The second hit may involve the passive transfer of neutrophil or HLA antibodies from the donor or the transfusion of biologically active lipids from older, cellular blood products. Treatment is supportive, with a prognosis substantially better than most causes of clinical acute lung injury. (CHEST 2004; 126:249 –258) Key words: ARDS; lung injury; pulmonary edema; transfusion; transfusion-related acute lung injury Abbreviations: ALI acute lung injury; FDA Food and Drug Administration; Fio2 fraction of inspired oxygen; HLA human leukocyte antigen; PRBC packed RBC; TRALI transfusion-related acute lung injury T ransfusion-relatedbyacute lung etinjuryin(TRALI) 1983 to was first coined Popovsky al 1 refer to noncardiogenic pulmonary...
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...Bodybuilding Anaerobic Exercise & Respiration, Muscular Growth and Supplement Intake Ajay Sabhaney, Carlen Ng, Di Wu, Kelei Xu Bodybuilding Page 1 of 59 Table of Contents 1. Introduction 2. The Body & Muscle Groups a. Muscle Growth b. Physical & Psychological Benefits of Exercising 3. Weight Training: Anaerobic Exercise Mechanics & Impact on Muscle Growth a. Energy Transformations During an Exercise b. Investigating Torque in Weight Training c. Muscles Acting as Levers d. Impulse in Weight Training e. Intensity versus Speed 4. Protein Supplementation a. Protein supplementation b. Combining Protein Supplementation 5. Cellular Respiration & Effect on Weight Training a. Glycolysis b. Aerobic Respiration c. Anaerobic Respiration (inc. lactic acid) d. Carbohydrate Loading 6. Creatine Supplementation a. An Introduction b. Lab: Effect of Phosphocreatine on Lactic Acid 7. Anabolic-Androgenic Steroids a. Reactions within the Body involving steroids b. Side Effects of Steroid Intake c. Detecting Steroids in the Human Body 8. Conclusion 9. Works Cited 10. Miscellaneous Bodybuilding Page 2 of 59 I. Introduction Exercise (essentially any form of physical exertion which results in the contraction of a muscle) has become a widespread interest over the past several years, especially in areas of weight training. While exercise is generally intended to promote good physical health, bodybuilding more specifically concentrates on building muscle mass and many individuals in society...
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...1tsp = 1tsp = 3tsp = 1tbsp = Household 1tsp=5cc 3tsp=1tbsp 1tbsp=0.5oz or 15cc 2tbsp=1oz or 30cc 1pt.=16oz or 480cc 1qt=32oz or 960cc 1/60 grain=1mg 15 grains=1g 2.2 lbs.=1kg Apothecary 1 dram 60 gtts (drops) 0.5 ounce 0.5 ounce Metric 5cc=1tsp 15cc=1tbsp 30cc=2tbsp(1oz) 1cc=16minims Apothecary 1fl.dram=4cc 4drams=0.5oz 8drams=2tbsp(1oz) 16minims=1cc 500cc=0.5L or 1pt. 1000cc=1L or 1qt. Temp. Conversion C= F-32/1.8 F= 1.8*C-32 2 Darren & Jenny Nursing Study Guide NOTES CARDIOVASCULAR Arterial Ulcer – Pale, deep base, surrounded by tissue that is cool with trophic changes such as dry, soluble skin and loss of hair. Cause by ischemia from inadequate arterial blood supply of oxygen and nutrients . Venous stasis Ulcer – Dark, red base, surrounded by skin that is brown in color with edema. Caused by the accumulation of waste products of metabolism that are not cleared due to venous congestion. Stage I Ulcer – Reddened area with intact skin surface. Management of DVT – Bed rest, limb elevation , relief of discomfort with warm, moist, heat and analgesics (Tylenol, not narcotics) prn. Ambulation is contraindicated. Sclerotherapy – Injection of a sclerosing agent into a varicosity. The agent damages the vessel and causes aseptic thrombosis that result in vein closure. With no blood flow thru the vessel, distention will not occur. The surgical procedure for varicose veins is vein ligation and stripping: tying off the varicose veins and large tributaries and then removal...
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