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Hypertrophic Cardiomyopathy

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This article talks about Hypertrophic cardiomyopathy (HCM), which is a heart muscle disorder. This disorder is thought to have an autosomal dominant inheritance. Based on the reports in India, the HCM is caused by mutations in sarcomeric, cytoskeletal and mitochondrial genes. This study tries to identify the epidemiological variables in HCM, trying to fit a model that assumes that HCM is a dominant type of inheritance. (Tanjore et al, 2011).

Epidemiology and genetics of hypertrophic cardiomyopathy
Introduction
Hypertrophic cardiomyopathy (HCM) is a genetically heterogeneous heart muscle disorder. This disorder is characterized by a left ventricular hypertrophy, with an involvement of interventricular septum. This disease affects …show more content…
All these patients were diagnosed with HCM based on the standard, clinical, electrocardiographic and echocardiographic criteria. Age, sex, duration of the disease, symptoms, family status and much more information was collected from all the patients.
HCM has the some of characteristics that are reflected in a hypertrophied heart. Here the patients can be classified as asymmetric septal hypertrophy without obstruction (ASH) for the flow of blood from the left ventricle, obstructive HCM (HOCM), concentric hypertrophy (Conc HCM), apical HCM, HCM with mid cavity obstruction (MCO) and hypertrophy in unusual locations. A technique of logistic regression was used to compare whether the probability of the disease is the same or different for different groups and is given by:
Odds Ratio = exp(b0+ b1) = eb1 …show more content…
HCM can also cause death, which can be very sudden sometimes. From previous studies about HCM, it was seen a mortality rate 2-6%. This high mortality rate could be explained with the presence of other diseases along the HCM. In this study was observed that the mortality rate for Obstructive HCM patient was twice as higher than non-obstructive form of HCM. These values of the mortality show the degree of the malignant nature of obstructive HCM. HCM and all the other forms of it, affect usually the people within the age of late 36. They also observed that the affected patients with HCM or all the other forms of it, showed symptoms of the disease in earlier age compared to their affected family members. In the study of Yung et al 2000 about the familial and non-familial cases of HCM, showed that the metabolite abnormalities are different in familial and non-familial cases. The individuals with a family history showed a very different metabolite ratio in the myocardium than their relatives, which shows that they will present their symptoms earlier because of their genetic inheritance predisposition. This showed that HCM and all its other forms are more influenced by the familial status than by age and

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