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Ibuprofen Essay

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All reactants were reagent grade and provided by the University of Colorado Denver Chemistry Department. FTIR spectra were obtained with a Nicolet iS5 ATR FTIR spectrometer and all measurements were in cm-1. The following abbreviations were used to describe transmittance bands: b (broad), n (narrow), sh (sharp), w (weak), m (medium), and s (strong).
Isolation of Ibuprofen:
15 tablets contain 200 mg ibuprofen was obtained resulting in 3.54 g (17.1 mmol) Ibuprofen. Add 25 mL of acetone to the beaker and stirred for 5-10 minutes. Vacuum filtration was used to remove the acetone insoluble components. The ibuprofen was concentrated using the rotary evaporation. The mass of the crude ibuprofen was 3.54 g (17.1 mmol, 118%). Melting point was 67.2-70.2°C. For the isolation of ibuprofen, the major peaks are 3399.16 cm-1 O-H stretch, H-bonded, 2979.17 cm-1 C-H stretch, and 1700.18 cm-1 C=O stretch
Formation of Diastereomeric Salts: …show more content…
The solution was heated to an internal temperature between 75 and 85°C. 0.9 mL of the S-(-)-α-phenethylamine (d=0.94g, 6.981 mmol) was added to the solution. Precipitation was formed. Heat was maintained between 75 and 85°C for one hour while stirring. After a hour, it was removed from heat and allowed to cool to room temperature. The salt was collect by vacuum filtration. Melting point was determined (167-173.4°C). The % yield was calculated (72.5%, 1.66g)
Recrystallization of Salt:
The crude salt was tared in a 100 mL beaker with a recorded mass of mass. 2-propanol (d=.785) was added and dissolved by heating the alcohol to a boil. The recrystallized salt was cooled and placed in an ice bath. The salt was recovered by vacuum filtration.
Recovery of

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