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Information Cause and Effect

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GENERIC NAME:LABETALOL - ORAL (luh-BET-uh-lol)
BRAND NAMES: Normodyne, Trandate
DRUG CLASS AND MECHANISM: Labetalol is a drug that is used for treating high blood pressure. Nerves from the adrenergic nervous system travel from the spinal cord to arteries where they release norepinephrine. Norepinephrine attaches to adrenergic receptors on arteries and causes the arteries to contract, narrowing the arteries, and increasing blood pressure. Labetalol blocks receptors of the adrenergic nervous system. When labetalol attaches to and blocks the receptors, arteries expand, resulting in a fall in blood pressure.
GENERIC AVAILABLE: Yes PRESCRIPTION: Yes
PREPARATION: Tablets: of 100, 200 and 300 mg; Injection: 5 mg/ml
STORAGE: Tablets should be stored between 2-30 C (36-86 F).
PRESCRIBED FOR: Labetalol is used alone or in combination with other drugs to reduce blood pressure.
DOSING: The recommended starting oral dose of labetalol is 100 mg twice daily and the dose can be increased by 100 mg twice daily every 2-3 days based on the response of the blood pressure. Usual maintenance doses are 200-400 mg twice daily. Patients with severely high blood pressure may require 1.2 to 2.4 g daily.
Stopping or changing the dose of the drug should be directed by a physician because serious side effects may occur. The initial intravenous dose of labetalol is 20 mg injected over 2 minutes. Additional injections of 40 or 80 mg may be administered every 10 minutes as needed up to a total dose of 300 mg.
DRUG INTERACTIONS: Labetalol can mask early warning symptoms of hypoglycemia (low blood sugar) such as tremors and increased heart rate which are the result of activation of the adrenergic nervous system. Therefore, people with diabetes taking medications that lower blood sugar such as insulin or oral antidiabetic medications may need to increase the frequency with which they monitor their blood sugar in order to prevent hypoglycemia.
Combining labetalol with tricyclic antidepressants such as amitriptyline ex. Elavil may lead to an increase in tremor which is a side effect of tricyclic antidepressants.
If combined with adrenergic stimulating drugs used for treating asthma, ex. albuterol the adrenergic blocking effects of labetalol may counteract the effects of the stimulating drugs and reduce their effectiveness for treating asthmatic attacks. More of the adrenergic drug may be needed.

SIDE EFFECTS: The most common side effects of labetalol are fatigue, dizziness, nausea, headache, diarrhea, edema (fluid accumulation), and shortness of breath. Postural hypotension (a rapid decrease in blood pressure when going from the lying or seated position to the standing position that may cause light-headedness or fainting) occurs rarely. Patients should be observed for this possible side effect within two to four hours of the first labetalol dose and after any changes in dose. Sexual dysfunction, abnormal heart rhythm, slow heart rate, liver failure, and allergic reactions may occur. GENERIC NAME:
Symptoms of a Labetalol Overdose: When someone takes too much labetalol, the symptoms can vary. Some examples of labetalol overdose signs and symptoms include: Difficulty breathing, Wheezing,Extremely low blood pressure, which may cause lightheadedness, dizziness, or fainting, Severe decrease in heart rate (bradycardia),Seizures, Congestive heart failure.
Treatment for an Overdose With Labetalol: If the overdose with labetalol was recent, the healthcare provider may administer certain medicines or place a tube into the stomach to "pump the stomach." However, there is no readily available treatment that can remove the medication quickly once it has been absorbed into the body. Therefore, in these cases, treatment involves supportive care. This type of care consists of relieving the symptoms that occur as a result of the overdose. For example, supportive treatment options for people who take too much labetalol may include: Fluids through an intravenous line (IV), Medications to increase blood pressure or heart rate, Medications to improve breathing, Medicines or placement of a pacemaker for abnormal heart rhythms, Close monitoring of the heart and lungs.

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