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Ischaemic Heart Disease Analysis

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According to the World Health Organisation ischaemic heart disease was the leading cause of death in the world in 2012. 7.4 million people died from the disease in 2012 with stroke being the second leading cause of death and chronic obstructive lung disease being the third top killer. [1] These deaths undoubtedly have devastating effects and put a major strain on the health system both as regards resources but also as regards finance. According to CNBC Ischaemic heart disease costs the United States approximately $108.9 billion per year. [2] Evidently major advancements in the treatment of the disease need to be undertaken. The current treatments of the disease only delay the progression of the disease but never actually cure it. The main aim …show more content…
Apoptosis, necrosis, and autophagy occurs in cardiac myocytes causing both gradual and acute cell death which are indications of cardiac pathology including heart failure, myocardial infarction and ischaemia. The heart is exposed to numerous stresses but only has a limited capacity to regenerate worn or damaged cells. It must be able to deal with and respond to these stresses. Development of new treatments to treat cardiac diseases is a major research goal at the moment. Pharmacological and genetic inhibition of cell death by apoptosis, necrosis and autophagy is a big area being looked at. Another key area is the replacement of these worn and dead cells. It was once thought that the loss of cardiac myocytes was a process that was irreversible. However the discovery of tissue resident cardiac stem cells and the function of bone marrow derived stem cells have changed this belief. Extensive research was sparked by these discoveries in an effort to use the regenerative properties of stem cells to repair damaged cardiac myocytes, improve the function of the heart and reduce the deaths due to cardiac related illnesses. …show more content…
One way to treat the disease is to replace the worn or damaged tissue with a new functional tissue or organ. Tissue engineering has evolved from the field of biomaterials development. The basic idea of tissue engineering is the combination of cells (patients cells or donor cells), a scaffold (a synthetic biological template), and biologically active compounds such as growth factors, adhesion factors and mechanical stimulation which act as signals. These three components are combined to produce an engineered tissue that is a functional structure that can restore, maintain or improve damaged tissues or entire organs. When stem cells and biomaterials are combined living cardiovascular devices can be generated. [6] A source of cells may be cardiovascular endothelial cells and myofibroblasts which can be found in autlologous vein and artery cells and umbilical cord cells. These cell sources may be acquired in vivo. Endothelial progenitor cells can theoretically be captured from the blood stream by being taken from the blood by recognition sites on the biomaterial structure. The scaffold is a structure which can be made of natural or artificial materials on which the tissue is grown to mimic a biological process outside the body for research and investigation or to replace a damage or worn tissue inside the body. The scaffold must mimic the structural elements of

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