Premium Essay

Joint Modelling of Multiple Phenotypes in Genome-Wide Associations Studies

In:

Submitted By yotsa
Words 463
Pages 2
Introduction
Genome-wide association study (GWAS) is now becoming a routine analysis when there are large-scale genotype data and phenotypes data available from a population. However, conventional statistical techniques used in GWAS have yielded very little information considering the amount of data available. Low statistical power due to weak genetic effects is a possible explanation for this but applying simplistic tests for association could be another reason. For instance, currently there is no established method for detecting pleiotropy, that is when a single genetic variant influences multiple outcomes, from genome-wide scans, and generally phenotypes, which are often strongly biologically related, are rarely modelled together. Therefore, a new method that can identify pleiotropic genetic loci and model related phenotypes from genome-wide association study is needed.
Method
In this project, a novel method for the detection of pleiotropic genetic effects based on the genome-wide association study approach is developed. The method models multiple phenotypes simultaneously and in doing so may improve the power to detect genetic variants effecting phenotypes as well as identifying pleiotropic effects. The Usual way of association testing between genetic variants and phenotypes of interest, where a single phenotype or trait is the response variable and a single nucleotide polymorphisms (SNP) is the predictor, is reversed such that SNP is the outcome and multiple phenotypes are modelled simultaneously as predictors. The regression models used in this method are logistic and ordinal regression, since SNP genotypes provide ordered categorical data with 2 or 3 categories. This method is called inverseREGRESS. The method is applied to data on nine metabolic phenotypes from the Northern Finland Birth Cohort of 1966 (NFBC1966), which were studied

Similar Documents

Premium Essay

None at This Time

...Obstacles and Opportunities for Collaboration Among Academia, Industry and Government Report of an Invitational Conference Organized by The Association of American Medical Colleges Food and Drug Administration Center for Drug Development Science, at the University of California, San Francisco January 13-14, 2005 Washington, DC David Korn, M.D. Donald R. Stanski, M.D. Editors DRUG DEVELOPMENT SCIENCE ACKNOWLEDGEMENTS This is the report of a conference convened by the Association of American Medical Colleges and the Food and Drug Administration in response to the FDA white paper entitled “Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Product Development”. The conference was partially supported by the FDA. The AAMC acknowledges with gratitude the additional support provided by Abbott Laboratories, Cephalon, Inc., Eli Lilly and Company, GlaxoSmith Kline, Merck & Co. Inc., and Pfizer, Inc. The conference planning committee consisted of Drs. David Korn, Joel Kupersmith, Carl Peck, Donald Stanski, and Janet Woodcock. Figures 1 and 2 are taken from the FDA white paper. The back cover composite is derived from charts presented at the conference by Dr. Peter Corr, Pfizer, Inc. The report was designed by Douglas Ortiz, AAMC. To request additional copies of this publication, please contact: Joi Morris Association of American Medical Colleges Division of Biomedical and Health Sciences Research 2450 N Street, NW Washington, DC 20037-1127 Phone: (202)...

Words: 14590 - Pages: 59

Free Essay

Artificial Neural Network for Biomedical Purpose

...ARTIFICIAL NEURAL NETWORKS METHODOLOGICAL ADVANCES AND BIOMEDICAL APPLICATIONS Edited by Kenji Suzuki Artificial Neural Networks - Methodological Advances and Biomedical Applications Edited by Kenji Suzuki Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2011 InTech All chapters are Open Access articles distributed under the Creative Commons Non Commercial Share Alike Attribution 3.0 license, which permits to copy, distribute, transmit, and adapt the work in any medium, so long as the original work is properly cited. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published articles. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Ivana Lorkovic Technical Editor Teodora Smiljanic Cover Designer Martina Sirotic Image Copyright Bruce Rolff, 2010. Used under license from Shutterstock.com First published March, 2011 Printed in...

Words: 43079 - Pages: 173

Premium Essay

Ib Biology Guide

...Biology guide First assessment 2016 Biology guide First assessment 2016 Diploma Programme Biology guide Published February 2014 Published on behalf of the International Baccalaureate Organization, a not-for-profit educational foundation of 15 Route des Morillons, 1218 Le Grand-Saconnex, Geneva, Switzerland by the International Baccalaureate Organization (UK) Ltd Peterson House, Malthouse Avenue, Cardiff Gate Cardiff, Wales CF23 8GL United Kingdom Website: www.ibo.org © International Baccalaureate Organization 2014 The International Baccalaureate Organization (known as the IB) offers four high-quality and challenging educational programmes for a worldwide community of schools, aiming to create a better, more peaceful world. This publication is one of a range of materials produced to support these programmes. The IB may use a variety of sources in its work and checks information to verify accuracy and authenticity, particularly when using community-based knowledge sources such as Wikipedia. The IB respects the principles of intellectual property and makes strenuous efforts to identify and obtain permission before publication from rights holders of all copyright material used. The IB is grateful for permissions received for material used in this publication and will be pleased to correct any errors or omissions at the earliest opportunity. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted...

Words: 43724 - Pages: 175

Free Essay

The Logistic Map

...Chaotic Growth with the Logistic Model of P.-F. Verhulst Hugo Pastijn Department of Mathematics, Royal Military Academy B-1000 Brussels, Belgium Hugo.Pastijn@rma.ac.be Summary. Pierre-Fran¸ois Verhulst was born 200 years ago. After a short biograc phy of P.-F. Verhulst in which the link with the Royal Military Academy in Brussels is emphasized, the early history of the so-called “Logistic Model” is described. The relationship with older growth models is discussed, and the motivation of Verhulst to introduce different kinds of limited growth models is presented. The (re-)discovery of the chaotic behaviour of the discrete version of this logistic model in the late previous century is reminded. We conclude by referring to some generalizations of the logistic model, which were used to describe growth and diffusion processes in the context of technological innovation, and for which the author studied the chaotic behaviour by means of a series of computer experiments, performed in the eighties of last century by means of the then emerging “micro-computer” technology. 1 P.-F. Verhulst and the Royal Military Academy in Brussels In the year 1844, at the age of 40, when Pierre-Fran¸ois Verhulst on November c 30 presented his contribution to the “M´moires de l’Acad´mie” of the young e e Belgian nation, a paper which was published the next year in “tome XVIII” with the title: “Recherches math´matiques sur la loi d’accroissement de la e population” (mathematical investigations of the law of...

Words: 138629 - Pages: 555

Premium Essay

Databasse Management

...Fundamentals of Database Systems Preface....................................................................................................................................................12 Contents of This Edition.....................................................................................................................13 Guidelines for Using This Book.........................................................................................................14 Acknowledgments ..............................................................................................................................15 Contents of This Edition.........................................................................................................................17 Guidelines for Using This Book.............................................................................................................19 Acknowledgments ..................................................................................................................................21 About the Authors ..................................................................................................................................22 Part 1: Basic Concepts............................................................................................................................23 Chapter 1: Databases and Database Users..........................................................................................23 ...

Words: 229471 - Pages: 918