...from the first and second trial. Their task is to determine whether the image was from the most recent presentation or the previous one.[6] In a route retrieval task spatial learning occurs where a participant virtual tours a particular place (such as a town or maze). Participants are asked to virtually tour the same thing at a later time while brain imaging is used to measure activity.[7] A paired word associative task consists of two phases. During the first phase (acquisition), the responses of the paired-associate task are learned and become recallable. In the second phase (associative phase), the subject learns to pair each response to a separate stimulus. For example a visual cue would provide information as to what words must be recalled after the stimulus and words are removed.[8] In a mirror tracing task participants are asked to trace several figures as fast and as accurately as possible which they can only see in a mirror. Speed is recorded as well as how much they deviate from the original image (accuracy).[8] In the Morris water maze task rats are used to test their spatial learning in two kinds of conditions: spatial and nonspatial. In the spatial condition, a platform is hidden by using murky water and in the nonspatial condition, the platform is visible. The spatial condition the rat must rely on their spatial memory to find the...
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...directly comparable. The last group, Group C, is the control group which receive rat food and water. On day 22, Group E and PF receive regular rat chow and water and on day 23, the rat pups are born. After the birth of the pups, it was found that there was no difference in the number of live versus the number of still born among the three groups. Even though the pups in Group E and PF weighed less and the moms in Group PF weighed less, this was only significant for a day, and the rats eventually caught up to the other groups. The newborn rats were taken at 22 days and separated into cages by litter. One male from each litter was chosen randomly to be a participant at 16 months old for the maze learning test. The Morris Water Maze uses water with a white paint for an opaque look inside of the maze box. A platform is placed inside the maze, in the same place for each trial, to give the rats a secure place to search for in order to rest and stop swimming. The latency, or time it takes to perform this task, is measured each time. The idea is, latency should decrease as the learning of the rat progresses. Each rat is given six trials over a ten day period. On the 59th trial, the platform is raised out of the water to test for a visual impairment issue. On the 60th trial, the rats are given a one minute span to search for the platform that has been removed entirely from the maze. From the results, it is clear that all of the rats improved, but the latencies for the rats...
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...The implications of the above results are discussed next. As it can be seen in Figure 1, ESSENDON1 drug seemed to not to be effective in the Forced Swim Test experiment. The data shows that there is a higher percentage of immobility in the control group (mean = 54.3 +12.4%) compared to the ESSENDON1 test group (mean = 47.5 +7.6 %). This indicates that the test group demonstrated to have less escape - related behaviour and was found to be more anxious than the control group. Moreover, the t–test (p=0.6497) indicates there is ~65% chance that the immobility is the same and hence there is no significant differences between the two groups. The bar graph of the Elevated plus-maze test in Figure 2 demonstrates the effectiveness of ESSENDON1. Through immediate observation, the...
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...joined Toxicol Laboratories Limited as Head of Mutagenicity. He was a president of the European Environmental Mutagen Society from August 2009- 2011 has edited 3 books on mutagenicity test guidelines, has published 90 scientific papers. He was appointed as a member of the UK Government Advisory Committee on Mutagenicity. David has been awarded Fellowship of the UKEMS and made an Honorary Professor of the University of Wales Swansea. 2. One publication is that Aspartame is a harmful food additive: Name: Studies on the effects of aspartame on memory and oxidative stress in brain of mice. Date: 2012 Dec Issue: The present study aimed to investigate the effect of repeated administration of aspartame in the working memory version of Morris water maze test, on oxidative stress and brain monoamines in brain of mice Name of the author: Prof. Omar M. E. Abdel-Salam Background: 1997 Ph.D., Medical Sciences, the Hungarian Academy of Science, Hungary 1991 M.Sc., Internal Medicine, Cairo University, Egypt 1985 B.Sc., Medical and Science, Cairo University, Egypt 3. A paragraph synopsis of opinion: Aspartame, an artificial and non-saccharide sweeter, is known as a ubiquitous sugar substitute in food and beverage market. However, the safety of long-term aspartame utilization has provoked the controversy amidst the health care and scientific experts. Although FDA, a federal agency of the United States Department of Health and Human Services, approved aspartame...
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...Brain, Behavior, and Immunity 37 (2014) 134–141 Contents lists available at ScienceDirect Brain, Behavior, and Immunity journal homepage: www.elsevier.com/locate/ybrbi Short exposure to a diet rich in both fat and sugar or sugar alone impairs place, but not object recognition memory in rats Jessica E. Beilharz a, Jayanthi Maniam b, Margaret J. Morris b,⇑ a b School of Medical Sciences, University of New South Wales, Australia Department of Pharmacology, School of Medical Sciences, University of New South Wales, Australia a r t i c l e i n f o Article history: Received 10 October 2013 Received in revised form 11 November 2013 Accepted 25 November 2013 Available online 3 December 2013 Keywords: Diet Fat Sugar Obesity Memory Learning Hippocampus Inflammation Oxidative stress a b s t r a c t High energy diets have been shown to impair cognition however, the rapidity of these effects, and the dietary component/s responsible are currently unclear. We conducted two experiments in rats to examine the effects of short-term exposure to a diet rich in sugar and fat or rich in sugar on object (perirhinaldependent) and place (hippocampal-dependent) recognition memory, and the role of inflammatory mediators in these responses. In Experiment 1, rats fed a cafeteria style diet containing chow supplemented with lard, cakes, biscuits, and a 10% sucrose solution performed worse on the place, but not the object recognition task, than chow fed control rats when tested after 5, 11, and 20 days...
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...Targeting Insulin Signaling in Treating Alzheimer’s Disease Name Institution Table of Contents Abstract 3 Summary 4 Introduction 5 Present Therapeutic Regimens for Alzheimer’s disease 5 Methods 7 Search Strategy 7 Exclusion/ Inclusion Criteria 8 Relevant Information 8 Results 9 Discussion of Results 12 Epidemiological information linking type 2 diabetes to AD 16 Insulin-signaling abnormalities in Alzheimer disease affected brain 17 Diabetes drugs in treatment for AD 19 Treatments regimens for type 2 diabetes Mellitus and their potential in treating AD 23 Thiazolidinediones (TZDs). 23 Metformin. 23 Amylin and Leptin analogs. 24 Findings 26 Interpretation of Results 26 Limitations 28 Future Research 29 Conclusion 31 References 32 Abstract Type 2 diabetic drugs could serve as potential in the treating Alzheimer’s disease. AD is a dementia defined by partial or total loss of memory. The risk of development of AD increases with age. Different therapeutic approaches have been employed when it comes to treatment of AD. Results of indicate that diabetic drugs are effective in treating Alzheimer ’s disease. Despite efforts directed at treatment of the condition, the results have not been satisfactory. This could be attributed to the early or late onset of AD pathogenesis while at the same time being underpinned by various mechanisms. There is evidence suggesting the effectiveness of type 2 diabetic drugs in treatment of AD. Research has focused on...
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...Targeting Insulin Signaling in Treating Alzheimer’s Disease Name Institution Table of Contents Abstract 3 Summary 4 Introduction 5 Present Therapeutic Regimens for Alzheimer’s disease 5 Methods 7 Search Strategy 7 Exclusion/ Inclusion Criteria 8 Relevant Information 8 Results 9 Discussion of Results 12 Epidemiological information linking type 2 diabetes to AD 16 Insulin-signaling abnormalities in Alzheimer disease affected brain 17 Diabetes drugs in treatment for AD 19 Treatments regimens for type 2 diabetes Mellitus and their potential in treating AD 23 Thiazolidinediones (TZDs). 23 Metformin. 23 Amylin and Leptin analogs. 24 Findings 26 Interpretation of Results 26 Limitations 28 Future Research 29 Conclusion 31 References 32 Abstract Type 2 diabetic drugs could serve as potential in the treating Alzheimer’s disease. AD is a dementia defined by partial or total loss of memory. The risk of development of AD increases with age. Different therapeutic approaches have been employed when it comes to treatment of AD. Results of indicate that diabetic drugs are effective in treating Alzheimer ’s disease. Despite efforts directed at treatment of the condition, the results have not been satisfactory. This could be attributed to the early or late onset of AD pathogenesis while at the same time being underpinned by various mechanisms. There is evidence suggesting the effectiveness of type 2 diabetic drugs in treatment of AD. Research has focused on understanding...
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...Zox by Susan Photos he s from t Excerpt With de ion GNuLiINE Broadcast DiscussPBS FRO T Welcome to POISONED WATERS This discussion guide and DVD are drawn from the PBS FRONTLINE investigative report, POISONED WATERS with Hedrick Smith as correspondent. In that program, we showed the kinds of pollution now contaminating America’s waterways, political obstacles blocking restoration of great estuaries like Chesapeake Bay and Puget Sound, and some local strategies that have scored successes. We have designed this kit to stimulate public discussion of effective techniques and crucial issues of educational reform. It is intended for teachers, parents, principals, administrators and anyone interested in improving public schools. Photo by: Susan Zox How To Use This Guide This guide can be used either with a DVD of the two-hour documentary, POISONED WATERS, or with the special DVD clip reel of program excerpts. The guide is broken into several sections. On pages 1 and 22, you’ll find a description of the main elements of the program. Pages 2-21 set out ten topics for discussion, selected to highlight important issues in protecting our waters. For example, stormwater runoff, agricultural pollution, new chemical contaminants, how grass-roots action can force a Superfund cleanup or control development. Each topic is covered by a two-page write-up and suggested questions. A matching video segment illustrates the issue. Select a topic and read the summary. Watch the matching segment on...
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...And Then There Were None by AGATHA CHRISTIE CHAPTER 1 IN THE CORNER of a first-class smoking carriage, Mr. Justice Wargrave, lately retired from the bench, puffed at a cigar and ran an interested eye through the political news in the Times. He laid the paper down and glanced out of the window. They were running now through Somerset. He glanced at his watch-another two hours to go. He went over in his mind all that had appeared in the papers about Indian Island. There had been its original purchase by an American millionaire who was crazy about yachting-and an account of the luxurious modern house he had built on this little island off the Devon coast. The unfortunate fact that the new third wife of the American millionaire was a bad sailor had led to the subsequent putting up of the house and island for sale. Various glowing advertisements of it had appeared in the papers. Then came the first bald statement that it had been bought-by a Mr. Owen. After that the rurnours of the gossip writers had started. Indian Island had really been bought by Miss Gabrielle Turl, the Hollywood film star! She wanted to spend some months there free from all publicity! Busy Bee had hinted delicately that it was to be an abode for Royalty??! Mr. Merryweather had had it whispered to him that it had been bought for a honeymoon-Young Lord L-- had surrendered to Cupid at last! Jonas knew for a fact that it had been purchased by the Admiralty with a view to carrying out some very hush hush experiments...
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...chapter 2 40 Chapter 2 you. I’ve asked Charlie Moody to come in today to talk about it. He’s waiting to speak with us.” When Charlie joined the meeting Fred said, “Hello, Charlie. As you know, the Board of Directors met today. They received a report on the expenses and lost production from the worm outbreak last month, and they directed us to improve the security of our technology. Gladys says you can help me understand what we need to do about it.” “To start with,” Charlie said, “instead of setting up a computer security solution, we need to develop an information security program. We need a thorough review of our policies and practices, and we need to establish an ongoing risk management program. There are some other things that are part of the process as well, but these would be a good start.” “Sounds expensive,” said Fred. Charlie looked at Gladys, then answered, “Well, there will be some extra expenses for specific controls and software tools, and we may have to slow down our product development projects a bit, but the program will be more of a change in our attitude about security than a spending spree. I don’t have accurate estimates yet, but you can be sure we’ll put cost-benefit worksheets in front of you before we spend any money.” Fred thought about this for a few seconds. “OK. What’s our next step?” Gladys answered, “First, we need to initiate a project plan to develop our new information security program. We’ll use our usual systems development and project...
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...management. 3. Negotiation—Cross-cultural studies. 4. Conflict management—Cross-cultural studies. I. Gelfand, Michele J. II. Brett, Jeanne M. bf637.n4 h365 2004 302.3—dc22 2003025169 Typeset by TechBooks in 10.5/12 Bembo Original printing 2004 Last figure below indicates year of this printing: 13 12 11 10 09 08 07 06 05 04 Contents List of Tables and Figures Foreword Preface xi xv ix part one. basic psychological processes Introduction 3 1. The Evolution of Cognition and Biases in Negotiation Research: An Examination of Cognition, Social Perception, Motivation, and Emotion 7 Leigh Thompson, Margaret Neale, and Marwan Sinaceur 2. Cultural Differences and Cognitive Dynamics: Expanding the Cognitive Perspective on Negotiation 45 Michael W Morris and Michele J. Gelfand . 3. I...
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...B. F. Skinner Burrhus Frederic (B. F.) Skinner (March 20, 1904 – August 18, 1990) was an American psychologist, behaviorist, author, inventor, and social philosopher.[1][2][3][4] He was the Edgar Pierce Professor of Psychology at Harvard University from 1958 until his retirement in 1974.[5] Skinner believed that human free will is an illusion and that any human action is the result of the consequences of the same action. If the consequences are bad, there is a high chance that the action will not be repeated; however if the consequences are good, the actions that led to it will become more probable.[6] Skinner called this the principle of reinforcement.[7] The use of reinforcement to strengthen behavior he called operant conditioning. As his main tool for studying operant conditioning Skinner The Skinners’ grave at Mount Auburn Cemetery invented the operant conditioning chamber, also known as the Skinner Box.[8] Skinner developed his own philosophy of science called radical behaviorism,[9] and founded a school of experimental research psychology—the experimental analysis of behavior. His analysis of human behavior culminated in his work Verbal Behavior, as well as his philosophical manifesto Walden Two, both of which still stimulate considerable experimental research and clinical application.[10] Contemporary academia considers Skinner a pioneer of modern behaviorism along with John B. Watson and Ivan Pavlov. Skinner emphasized rate of response as a dependent variable in psychological...
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...------------------------------------------------- Act 1, Scene 1 | Original Text | Modern Text | | Enter THESEUS, HIPPOLYTA, and PHILOSTRATE, with others | THESEUS and HIPPOLYTA enter withPHILOSTRATE and others. | 5 | THESEUSNow, fair Hippolyta, our nuptial hourDraws on apace. Four happy days bring inAnother moon. But oh, methinks how slowThis old moon wanes! She lingers my desires,Like to a stepdame or a dowagerLong withering out a young man’s revenue. | THESEUSOur wedding day is almost here, my beautiful Hippolyta. We’ll be getting married in four days, on the day of the new moon. But it seems to me that the days are passing too slowly—the old moon is taking too long to fade away! That old, slow moon is keeping me from getting what I want, just like an old widow makes her stepson wait to get his inheritance. | 10 | HIPPOLYTAFour days will quickly steep themselves in night.Four nights will quickly dream away the time.And then the moon, like to a silver bowNew bent in heaven, shall behold the nightOf our solemnities. | HIPPOLYTANo, you’ll see, four days will quickly turn into four nights. And since we dream at night, time passes quickly then. Finally the new moon, curved like a silver bow in the sky, will look down on our wedding celebration. | 15 | THESEUS Go, Philostrate,Stir up the Athenian youth to merriments.Awake the pert and nimble spirit of mirth.Turn melancholy forth to funerals.The pale companion is not for our pomp. | THESEUSGo, Philostrate...
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...HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use ADDERALL XR safely and effectively. See full prescribing information for ADDERALL XR. ADDERALL XR® (mixed salts of a single-entity amphetamine product) dextroamphetamine sulfate, dextroamphetamine saccharate, amphetamine aspartate monohydrate, amphetamine sulfate capsules, CII Initial U.S. Approval: 2001 WARNING: POTENTIAL FOR ABUSE See full prescribing information for complete boxed warning • Amphetamines have a high potential for abuse; prolonged administration may lead to dependence. (9) • Misuse of amphetamines may cause sudden death and serious cardiovascular adverse reactions. -----RECENT MAJOR CHANGES----Warnings and Precautions (5.5) 6/2013 -----INDICATIONS AND USAGE----ADDERALL XR, a CNS stimulant, is indicated for the treatment of attention deficit hyperactivity disorder (ADHD). (1) • Children (ages 6-12): Efficacy was established in one 3-week outpatient, controlled trial and one analogue classroom, controlled trial in children with ADHD. (14) • Adolescents (ages 13-17): Efficacy was established in one 4-week controlled trial in adolescents with ADHD. (14) • Adults: Efficacy was established in one 4-week controlled trial in adults with ADHD. (14) -----DOSAGE AND ADMINISTRATION----• Pediatric patients (ages 6-17): 10 mg once daily in the morning. The maximum dose for children 6-12 is 30 mg once daily. (2.1, 2.2, 2.3) • Adults: 20 mg once daily...
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...European Management Journal (2010) 28, 421– 440 journal homepage: www.elsevier.com/locate/emj International human resource management challenges in Canadian development INGOs Sharon L. OÕSullivan * Telfer School of Management, University of Ottawa, 55 Laurier ave East, Ottawa, ON, Canada, K1N 6N5 KEYWORDS International human resource management; International non-governmental organization; International development; Northern NGOs; Canada; Capacity building Summary Over $100 million of Canadian overseas development assistance (ODA) is channeled through international non-governmental organizations (INGOs) (CIDA, 2006). Although INGOs appear to be successful at circumventing many challenges in international development (Sachs, 2007), empirical research attesting to their international human resource management (IHRM) challenges is sparse, particularly in regard to secular, Northern INGOs. This paper responds by investigating the IHRM challenges facing Canadian INGOs as they implement ODA-funded projects in the field, and by exploring how such challenges may vary in different types of INGOs. The methodology involved semistructured interviews with 31 managers in three different Canadian development INGOs. Practical and theoretical implications are discussed. ª 2010 Elsevier Ltd. All rights reserved. Introduction The term INGO refers to ‘‘international non-governmental organization’’ (Roberts et al., 2005). Such organizations exist for diverse socioeconomic reasons...
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