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Multiple Sclerosis Case Study

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There are a several variables that can increase a person’s risk to developing multiple sclerosis. Some of these factors include latitude, smoking, gender, and age. The frequency of multiple sclerosis increases with increasing latitude worldwide (Ascherio & Munger, 2007b). One of the strongest connections between latitude and the risk of multiple sclerosis is the amount of time spent in the sun and the intensity of the sun’s rays (Ascherio & Munger, 2007b). The most common hypothesis to explain the association between the sun and risk of multiple sclerosis is the amount of in vitamin D intake. A study done by Munger et al. (2004) found that one’s susceptibility to multiple sclerosis is inversely related to their total amount of vitamin D intake. …show more content…
A study done on a large population in Norway showed that people who smoke have almost twice the incidence rate of multiple sclerosis as non-smokers (Riise, Nortvedt, & Ascherio, 2003). Another study demonstrated that the frequency of multiple sclerosis is found to be higher when people have smoked 4 years prior to being diagnosed (Hernan, Olek, & Ascherio, 2001b). Furthermore, the number of packs smoked per year is positively correlated with multiple sclerosis such that people who smoke 25 or more pack years have the greatest risk of multiple sclerosis (Hernan et al., 2001b). Since the number of female smokers has increased during the 20th century, it could be a logical explanation for the rise in female occurrence compared to males in the last few decades (Alonso & Hernán, 2009). The length and frequency of respiratory infections, which have been associated with multiple sclerosis, increase in response to cigarette smoke (Graham 1990). Smoking has also been linked to an acceleration of the stages and symptoms of multiple sclerosis (Hernan et al., 2005), possibly due to the neurotoxic chemicals in cigarettes, which have previously been shown to cause an increase in the risk to other autoimmune disorders (Smith, Duckett, & Waters, 1963). Development of multiple sclerosis has also been linked to leakage of the blood-brain barrier, which can be caused when nicotine, a …show more content…
The likelihood of females being diagnosed with multiple sclerosis compared to males has increased from 2.3 to 3.5 times more likely in the past few decades (Harbo, Gold, & Tintoré, 2013). In particular, Alonso and Hernán (2009) found that the probability of being afflicted with multiple sclerosis throughout one’s life is 2.5% for females and 1.4% in males. However, although females have a higher susceptibility rate than males, the ramifications of the disease are usually more severe in males. Female’s experience onset of the disease earlier in life than males, but the advancement of the disease is slow for females, whereas males experience a high number of attacks and symptoms earlier than females after diagnosis (Bergamaschi 2007). While the main determinant for the difference between male and female susceptibility has not been established, there are multiple hypotheses. Until recently, pregnancy was thought to have a negative association with development of multiple sclerosis. However, Ponsonby et al. (2012) show that the more children that a mother conceives in her life, the lower her risk will be from the initial attack of multiple sclerosis. One explanation for this could be that during pregnancy, the mother has elevated levels of the sex hormones progesterone, oestriol, and oestradiol (Harbo et al., 2013). This alteration in the hormonal levels of the mother may influence the development of multiple

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