...Wiliam Gajski Ja idem na biologiju about an hour ago via mobile · Like Luka Lapanja iz cega ces ucit? jel imas nekakve knjige, skripte ili neki k pa da mogu fotokopirat about an hour ago via mobile · Like Wiliam Gajski Imam skripte kaj mi je dala od zene neka frendica kaj ide na pripreme iz bio.. briem da ima oko 130 str about an hour ago via mobile · Like · 1 Luka Lapanja Aj jel moš to donijet u školu, pa da si fotokopiram to 4 minutes ago · Like Wiliam Gajski moram pogledat dal mi opce doma il kod zene about a minute ago via mobile · Like Luka Lapanja dobro, samo molim te ako možeš to dofurat ovih dana a few seconds ago · Like Luka Lapanja pa ti ja slijedeći vratim a few seconds ago · Like Options OLDER POSTS Diana Dee Dee Jašarević jel ko napiso eng??? koja tema je najlaksa ( makar meni nijedna nije xd ) Like · · Follow Post · 5 hours ago Seen by 15 View all 9 comments Dominik Cvijanović Eee paa sad 4 hours ago · Like Diana Dee Dee Jašarević joj joj ... sto reci 4 hours ago · Like Options Antonija Gabrić jel gledala potacek izostanke? Like · · Follow Post · 8 hours ago Seen by 16 Luka Lapanja and Diana Dee Dee Jašarević like this. View all 15 comments Diana Dee Dee Jašarević kurvaa 7 hours ago via mobile · Like Antonija Gabrić 7 hours ago · Like Options Dominik Cvijanović Laura Šeremet nam je u vezi sa Biciklom tj sad je sa Motorkom hahahahahhahaha eee ako ona moze nac decka onda svatko moze hahahahaha ...
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...in revised form 5 August 2004; accepted 10 August 2004 Available online 25 September 2004 Abstract Natural killer (NK) cells are a subset of lymphocytes that play a central role in the innate immune response to tumors and infections. An important limitation in the field of NK research is attributable to the deficit of assays available for the detection of the functional activity of NK cells. Recently, lysosomal-associated membrane protein-1 (LAMP-1 or CD107a) has been described as a marker of CD8+ T-cell degranulation following stimulation. Here we describe CD107a as a marker of NK cell functional activity using multi-parameter flow cytometry. CD107a is significantly upregulated on the surface of NK cells following stimulation with MHC devoid targets. Additionally, CD107a expression correlates with both cytokine secretion and NK cell-mediated lysis of target cells. However, as well as being coordinately expressed on nearly all cytokine secreting cells, CD107a was also expressed on a large subset of NK cells that did not secrete cytokine following stimulation. These data suggest that employing CD107a as a marker of NK cell functional activity may allow for the identification of a large fraction of activated NK cells that may degranulate in the absence of cytokine secretion. Cumulatively, the data presented here demonstrate that CD107a is a sensitive marker of NK cell activity. D 2004 Elsevier B.V. All rights reserved. Keywords: Natural Killer Cells; IFN-g; TNF-a; CD107a;...
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