This sequence codes for: Dystrophin gene codes for an important muscle protein called dystrophin that helps maintain and hold together the structure of muscle cells.
Localization: The DMD gene is located on the short (p) arm of the X chromosome at position 21.2. In a membrane-spanning protein complex it is located at the muscle sarcolemma that connects the cytoskeleton to the basal lamina.
Gene expression: In the Dystrophin gene, there are 7 tissue-specific promoters. The promoters responsible for transcription are dp427m, dp427c, dp427p, dp260, dp140, dp116, and dp71 respectively. Its expression in muscle cells is brought by dystrophin promoter bending factor (DPBF) and the binding of positive regulators serum response factor on a regulatory CArG element present on the promoter.…show more content… Listed are the protein kinases and their effected changes.
cAMP-dependent protein kinase (PKA) Indirectly produces a conformational change in the N-ABD, enriching its affinity for myofibrillar actin
Protein kinase C (PKC) An inhibitory effect on the dystrophin-actin interaction
Casein kinase II (CKII) An inhibitory effect on the dystrophin-actin interaction
Glycogen-synthase kinase (GSK3) Inhibitor of ERMS growth inhibiting proliferation and inducing terminal differentiation in myosin expressing cells p34cdc2 protein kinase Phosphorylates both identified residues in recombinant CT
