1.1.12 patient factors:
Health susceptibility to side effects (eg, organ damage, reduced physiological reserve) Current medical therapy with drugs likely to interact adherence to therapy or follow-up monitoring risk beliefs and attitude to history of previous adverse reactions

1.1.13 Prescriber factors:
Familiarity with the prescribing decisions Simple sequence: may depend on resources
1.1.13 pharmacokinetics:
Drugs in the same class (or different formulations of the same drug) can have different bioavailability, dose-concentration curves and half-lives. These factors will determine the dosage regimen. Once daily dosing is convenient and promotes compliance. The pharmacokinetic properties may also affect inter-individual variability in dosage requirements. For example, some drugs:
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For example, the dose of simvastatin should not exceed 20 mg nocte in patients amiodarone, verapamil increased due to the increased risk of muscle toxicity.
1.1.15.c Other patient factors:
The probability that patients adhere to the treatment and aftercare is important for drugs such as warfarin and insulin, which have a narrow therapeutic index and where alternatives are less effective. Health beliefs and attitude to risk may affect the initial decision to prescribe or the selection of drugs. This is in long-term preventive therapy, particularly in the services can not be perceived. About half of the patients adhere poorly to such treatments, emphasizes the role of patients in partnership for rational prescribing decisions
1.1.16 Prescriber factors influencing drug selection:
1.1.16.a familiarity:
Unfamiliarity prescribers of drugs increases the chance of negative results, mandating continuing vocational training. However, lack of experience of the introduction of new, more rational prescribing practices should not