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Salutary effects of carica papaya leaf extract in dengue fever patients

Salutary effects of carica papaya leaf extract in dengue fever patients – a pilot study
S Hettige1 Sri Lankan Family Physician, 2008, 29, 17-19

Introduction Dengue is a mosquito-borne infection which in recent decades has become a major international public health problem. Dengue is prevalent in tropical and sub-tropical regions around the world, predominantly in urban and semiurban areas1. In Sri Lanka dengue is currently also spreading to rural areas and has reached epidemic proportions. It has become a major public health problem2. Dengue Haemorrhagic Fever (DHF), a potentially lethal complication, was first recognized in the 1950s during dengue epidemics in the Philippines and Thailand. Today DHF affects most Asian countries and has become a leading cause of hospitalization and death among children in the region1. There are four distinct types, but closely related viruses which cause dengue. Recovery from infection by one type provides lifelong immunity against that virus but confers only partial and transient protection against subsequent infection by the other three types of viruses. There is evidence that sequential infection increases the risk of developing DHF3. Up to date there is no specific treatment for dengue fever. Lack of adequate global interest and funding have greatly restricted the development of treatment regimes4. The current dengue epidemic has resulted in over 200 deaths in Sri Lanka2. Ayurvedic literature reveals that papaya (Carica papaya) leaf extract has haemostatic and other medicinal properties 5,6,7,8,9. Further, recent e-mails and internet communications revealed the beneficial effects of papaya leaf extract in Asian patients who have dengue haemorrhagic fever10,11. However, no formal research has been done on the subject. It is important to conduct

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