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Pertussis Research Paper

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Pertussis is a highly contagious and vaccine-preventable acute respiratory infection caused mainly by Bordetella pertussis. This organism is a gram-negative, fastidious, pleomorphic bacillus, and the cause of whooping cough has remained one of the main 10 causes of death in infants in the world (A,B). Pertussis can occur at all ages, but the severity is higher among young infants who have not completed their immunization schedule (C,D). Although the disease has been decreased following the introduction of whole cell pertussis vaccines (WPVs) in the 1950s, many studies have described re-emergence of pertussis during the last decade (E,F). Therefore, pertussis has not yet been eradicated due to the following criteria 1) the difficulties related …show more content…
Since pertussis often presents atypical manifestations in ad¬olescents and adults, such as asymptomatic infections and a chronic cough, rather than typical pertussis symptoms, it may be overlooked. Therefore, this population can be the potential source of infection, particularly to younger infants (N,O). Studies have shown that there were approximately 48.5 million annual cases of pertussis and 295,000 deaths worldwide (P). This fact proves the necessity to the national epidemiological searches (Q). Seroepidemiological surveys are widely used to study the incidence of bacterial infections. The determination of the seroepidemiology of pertussis helps the evaluation of pertussis infection and immunity patterns in a population, and the definition of the target population for pertussis booster vaccinations can help in the way of disease control (R,S). This review was performed to determine the epidemiology of pertussis in Asia. The results of this study can be helpful in getting a picture of the B. pertussis incidence rate in this area and also designing a strategy for vaccination in adolescents and

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