...C Marginalized APC Inc. Top 10 BioPharma Companies: Key Annual Financial Metrics APC $ (mil) Net Sales Cost of Products Sold $19,152 $5,098 26.6% % Genentech $ (mil) $36,017 $9,797 27.2% % Amgen $ (mil) $14,642 $4,070 27.8% 72.2% 18.1% 8.3% % Novo Nordisk $ (mil) $9,566 $2,506 $7,060 $1,636 $890 26.2% 73.8% 17.1% 9.3% % Merck Serono $ (mil) $7,454 $2,020 $5,434 $1,327 $581 27.1% 72.9% 17.8% 7.8% % Baxter BioScience $ (mil) $5,573 $1,494 $4,079 $1,031 $568 27% 73.2% 18.5% 10.2% % Biogen Idec $ (mil) $4,247 $1,249 $2,998 $824 $446 29.4% 70.6% 19.4% 10.5% % Genzyme $ (mil) $3,562 $1,104 $2,458 $705 $349 31.0% 69.0% 19.8% 9.8% % CSL Ltd.* $ (mil) $3,211 $967 $2,244 $581 $350 30.1% 69.9% 18.1% 10.9% % Allergan $ (mil) $1,310 $385 $925 $258 $152 29.4% 28.2% 27.0% 70.6% 71.8% 73.0% 19.7% 18.5% 17.8% 11.6% 9.8% 9.0% % Top 10 Top 5 % % Gross Margin $14,054 73.4% $26,220 Marketing, Selling and Administrative $3,508 18.3% $6,447 Advertising and Product Promotions $2,209 11.5% $2,917 Total SG&A Research and Development Operating Margin Total Expenses $5,717 29.9% $3,464 18.1% $4,873 72.8% $10,572 17.9% 8.1% $2,650 $1,215 $9,364 26.0% $6,591 18.3% 28.5% $3,865 26.4% $2,606 $4,100 17.8% 28.0% $2,525 26.4% $1,856 $2,678 19.4% 28.0% $1,908 25.6% $1,312 $2,214 17.6% 29.7% $1,599 28.7% $1,003 $1,477 18.0% 26.5% $1,270 29.9% $756 $973 17.8% 22.9% $1,054 29.6% $616 $787 17.3% 22.1% $931 29.0% $706 $607 22.0% 18.9% $410 31.3% 28.3% 26.9% $288 $227 22.0% 18.8% 18...
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...Sanofi and Regenoron’s ODYSSEY Program is a collection of clinical trials. The ODYSSEY Phase 3 program, which is comprised of 14 global clinical trials and includes more than 25, 500 patients, represents the largest collection of clinical trials ever conducted for an investigational LDL cholesterol lowering drug. Based on the trials designed to evaluate the efficacy and safety of biweekly Alirocumab in patients with primary or secondary hypercholsteremia, Alirocumab treatment demonstrated not only consistent lowering LDL-C effects, but also tolerability and safety comparable to oral statins. Namely, in their 78 week randomized control trial (RCT) that involved 2341 patients with LDL levels of 70 mg per deciliter or higher, Robinson et al., (2015) claim that Alirocumab is highly effective at lowering LDL cholesterol levels when combined with a statin. Not only did Alirocumab yield significant bad cholesterol...
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...decisions in collaboration with the discovery and full-development groups. The highest-quality and highest-potential discovery compounds are quickly and efficiently moved through preclinical development and into initial human trials. DE employees experience a genuine and unique opportunity to shape the R&D pipeline in J&J and ultimately influence patient well-being. It is an exciting and challenging place to be in. Most of the first half of 2001 was spent in merger and integration activity with the groups, while moving compounds through the pipeline. The DE management team has overall responsibility for the organization and consists of the global head of DE and seven direct reports representing chemical pharmaceuticals, clinical drug evaluation, clinical operations, and portfolio...
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...drug making through this rigorous process of testing. The most popular and most profitable drugs from Merck include Vasotec, Mevacor, Prinivil and Pepcid, generating $5.7 billion in worldwide sales, in the year 2000. The patents for these drugs stand to expire in 2002, making the formula for these drugs available for generic drug makers. This would cut into the anticipated sales of these drugs, since Merck would no longer be the sole manufacturer of these drugs. Any new drug will take longer than the two years to become marketable. In order to offset this, Merck is considering the purchase of the licenses for Davanrik from LAB Pharmaceuticals. Davenrik has just completed pre-clinical development and is ready for the clinical approval process of 7 years. If purchased, Merck would be responsible for the clinical trial process. Merck has hired us to determine if it should buy the licenses of Davanrik from LAB Pharmaceuticals. Merck has retained us to determine the financial viability of entering into the licensing agreement. We used the Net Present value of the Future Cash Flow and the effective payoff method to determine if...
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...making through this rigorous process of testing. The most popular and most profitable drugs from Merck include Vasotec, Mevacor, Prinivil and Pepcid, generating $5.7 billion in worldwide sales, in the year 2000. The patents for these drugs stand to expire in 2002, making the formula for these drugs available for generic drug makers. This would cut into the anticipated sales of these drugs, since Merck would no longer be the sole manufacturer of these drugs. Any new drug will take longer than the two years to become marketable. In order to offset this, Merck is considering the purchase of the licenses for Davanrik from LAB Pharmaceuticals. Davenrik has just completed pre-clinical development and is ready for the clinical approval process of 7 years. If purchased, Merck would be responsible for the clinical trial process. Merck has hired us to determine if it should buy the licenses of Davanrik from LAB Pharmaceuticals. Merck has retained us to determine the financial viability of entering into the licensing agreement. We used the Net Present value of the Future Cash Flow and the effective payoff method to...
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...Process New drug development process has three major steps that cost the company over $500 million. The first step starts with preclinical studies. At this stage, new drug is tested on animals with the primary aim of examining its pharmacological and therapeutic compounds as well biologically dangerous compounds. The second step is the Investigational New Drug Application (IND). At this stage, the drug is submitted to the Food and Drug Administration (FDA) for approval before testing it on humans. The company is expected to give details with regard to compound composition, protocols that will be applied in Phase 1 and the clinical research plan. More than 5000 compounds are submitted for clinical testing but only one of them is approved for marketing (Sharp, 2001). Approval is granted within a period of one month and this marks the onset of clinical testing on human beings and comprises of three phases. At first, the drug is tested on a few healthy individuals (10-30) to ascertain that the drug is safe and can be tested on patients. Phase 1 focuses on safety but not drug’s efficiency (Sharp, 2001). Phase 2 utilizes a larger population...
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...physicians and patients. Food and Drug Agency’s Drug Approval Process “For healthcare technology, the most important regulatory approval comes from the federal Food and Drug Administration (FDA)” (Williams & Torrens, 2008, pg.28). This agency approves all drugs and pharmaceuticals, medical devices, and some medical equipment. The FDA also controls access to drugs by deciding whether a certain drug will be available by prescription only or as an over-the-counter purchase (Shi & Singh, 2013, pg.115). The most well-known regulatory review of medical technology is that conducted on pharmaceutical products and to some medical devices that are subjected to detailed preliminary approvals, clinical trials, and post-approval surveillance policies. Before a drug can begin (first phase) clinical testing, the sponsor of the drug must evaluate the product’s safety and biological activity via in vitro and in vivo lab (animal) testing. If product appears to have important biological activity and may be useful as a drug, special test are done to evaluate its safety in the major organ systems. These studies are conducted in animals to ensure a drug is safe enough to be tested in humans. At minimum the sponsor is required to develop a pharmacologic profile of the products effects, determine its...
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...Bachelor of Science in Nursing Hospital Pakar Sultanah Fatimah Muar 3rd September- 23 November 2012 Clinical Planning BSN July 09- Clinical Practice VI Roster | Clinical Learning Outcome | Clinical Plan Activity | 3rd-Sept- 12 OctoberGroup 3: - 4 BSN with 7 DIN studentsWeek 13rd -7th Sept Week 210th-14th SeptGroup 1: - 4 BSN with 7 DIN studentsWeek 317th- 21st Sept Week 424th-28th SeptGroup 2 : - 4 BSN with 7 DIN studentsWeek 51st-5th Oct Week 68th-12th Oct15 October-23 NovemberBSN July ‘09Ward 5 Surgical/Eye/ENT Clinic15 Octo-26 OctGroup 1-7 StnGroup 2- 8 StnWard 10 Medical /Hemodialysis29 Oct-9NovGroup 1-7 StnGroup 2- 8 StnOrtho Clinic/Physio Clinic12 Nov-16 Nov ( Holiday)19 Nov-23 NovGroup 1-7 StnGroup 2- 8 Stn | Hospital OrientationWARD 17Pediatric WardBSN Clinical Practice VI AN 3320 * Clinical Learning Objective: 1. Provide individualized quality care to all assigned clients following the nursing process 2. Perform management and organizational ability during the provision of nursing care 3. Apply critical appraisal skills to evaluate the available evidence which underpins practice 4. Plan health promotion activities for clients and family to maintain appropriate behaviors to attain or maintain health 5. Integrate significance of research in clinical practice to achieve best patient outcomesSpecific Objectives: * Plan timely execution of nursing task in the ward * Perform independent learning through self-study and reflective practice...
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...educational experience between the Associate Nursing Degree, diploma and the Baccalaureate prepared nurse. Each level of nursing education has had a part of the development of what nursing is today. The nursing shortage has also contributed to the different education levels in the attempt to provide staff in the nursing field Creasia) The associate degree nursing program consists of two years of schooling and clinical experience. The programs are connected to community colleges, technical schools, and some Universities. The programs consist of teaching nursing information, the sciences, and general education to support then nursing curriculum. The programs touch on evidence –based making, but do not emphasize it. Diploma nurses are affiliated with a college or university where general education and sciences are taught. The programs are 3 years in length usually and have an emphasis on clinical concepts of nursing. Some do require some liberal arts and will award an associate degree in liberal arts. The baccalaureate degree nurses have 4 years of education and clinical experience. The...
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...1. Cross-sectional studies (also known as cross-sectional analyses, transversal studies, prevalence study) form a class of research methods that involve observation of all of a population, or a representative subset, at one specific point in time. They differ from case-control studies in that they aim to provide data on the entire population under study, whereas case-control studies typically include only individuals with a specific characteristic, with a sample, often a tiny minority, of the rest of the population. Cross-sectional studies are descriptive studies (neither longitudinal nor experimental). Unlike case-control studies, they can be used to describe, not only the Odds ratio, but also absolute risks and relative risks from prevalences (sometimes called prevalence risk ratio, or PRR).[1][2] They may be used to describe some feature of the population, such as prevalence of an illness, or they may support inferences of cause and effect. Longitudinal studies differ from both in making a series of observations more than once on members of the study population over a period of time. Cross-sectional studies in medicine Cross-sectional studies involve data collected at a defined time. They are often used to assess the prevalence of acute or chronic conditions, or to answer questions about the causes of disease or the results of medical intervention. They may also be described as censuses. Cross-sectional studies may involve special data collection, including questions about...
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...Describe the benefits that information management and electronic information systems brings to delivery of informed, safe, and quality healthcare. Discuss how healthcare informatics might be integrated into the pre-licensure nursing curriculum. Provide two examples of teaching strategies utilizing the following: Electronic health record as a learning tool A teaching strategy from the QSEN project specifying a specific student assignment relevant to nursing informatics. Conclude your discussion with a well-developed reflection on the significance of healthcare informatics to 21st century nursing education. In response to the Institution of Medicine call to improve the quality of healthcare the Quality and Safety Education for Nurses (QSEN) initiative was started. The QSEN initiative consisted of the development of quality and safety competencies that serve as a resource for nursing faculty to integrate contemporary quality and safety content into nursing education. Nurses are on the front line of patient safety. It is important for the nursing profession to realize all the benefits healthcare informatics can offer to ease their jobs and improve patient safety. Introducing health care informatics into the nursing curriculum will prepare the student for new and innovative technologies on the horizon in the healthcare community. Safety benefits are consistent with the use electronic health record. If electronic medical records are being used by the nurse, the physician...
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...Shelia Ward Psych/ 270 ABNORMAL PSYCHOLOGY: ABUSE, ADDICTION, & DISORDERS (AXIA) Clinical Assessment April 24, 2011 Assignment: Clinical Assessment Pre-consultation is the first initial contact with the potential clients, the documents of Clara’s medical history must be submitted for review, along with a documentation from her teachers at the pre-school pertaining to their observations with Clara. At this point any other documentation obtained prior to the adoption that may give further insight to evaluating Clara. In meeting with Clara and her adoptive parents the issue of Clara’s age and environment is the beginning process in evaluating the issues surrounding Clara. I recognize that questioning a four- year old child could appear to be very intimidating and frightening; therefore, the interview will be addressed in several phases to avoid overwhelming Clara. The first phase will initiate Clara be taken to a playroom, and observed by my associate and recorded while playing with dolls...
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...This assignment will evaluate and explore the experience of mentoring a student in practice, critically analysing topics that will reflect on the role of the mentor, within the context of the nursing profession. The placement area concerned is a 14 bedded acute elderly assessment ward, which caters for both male and female patients. Several students have been placed on our ward over the years, it is the mentors responsibility to provide students with appropriate support, guidance and supervision within the clinical environment, Myall 2008. One of the key issues that need to be considered in preparation for an effective learning environment would be making sure the student is aware of the situations that could arise on the ward, discussing typical events that could happen on a daily basis. clinical experience can be a stressful part of the nursing program, working in a unfamiliar area, working with difficult patients and the fear of making mistakes. Hutchinson (2003) believes that a teacher should aim to provide an environment in which learners feel safe to experiment, voice their concerns, identify their lack of knowledge and stretch their limits. One of the major factors affecting learning is the environment in which it takes place. It is the responsibility of professional staff to create and develop an environment conductive to learning (Price, 2004). This implies that the environment should be continually monitored...
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...Nursing 101 The Art and Science of Nursing Spring 2013 PRE-REQUISITES AND CO-REQUISITES: None COURSE CREDITS AND COURSE HOURS: 3 credits (3, 1, 2) GRADING SCALE: Refer to 2011/2012 CNC Calendar, p. 110 COURSE DESCRIPTION: This course introduces the beginning student to the dimensions of professional nursing practice. Through group and individual learning activities, students are introduced to concepts, professional nursing practice, issues & trends in nursing, and the Canadian health care system. This course establishes the foundation for your future nursing career. COURSE STRUCTURE: Classes are delivered using lecture, discussion, group work, and lab and clinical experiences. There is also an online component to the course. Please visit the Nursing 101 Moodle shell regularly for readings and submission of assignments. There are required readings assigned for each week and material from these readings will be applied during class activities. It is expected that students will have completed the required readings, as this will help facilitate each students’ active participation in the course and the achievement of learning outcomes. All required and supplemental readings are testable material. STUDENT REQUIREMENTS: PARTICIPATION IN ALL LAB AND CLINICAL SESSIONS IS MANDATORY. FAILURE TO ATTEND YOUR SCHEDULED SESSION WILL RESULT IN FAILURE OF NURSING 101. (See policy regarding illness in student handbook & CRNBC Fitness to Practice Requirements). You must...
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... | | | | | ADN Student Clinical Experience |Fall 2009 |Medical Center of Plano, Plano Texas. Clinical time split between telemetry floor and women’s services. | | |Obstetric Rotation – Labor & Delivery, newborn nursery, and postpartum rotation performed at Wilson N. | | |Jones Hospital, Sherman Texas. | | |Rotated one day each in ICU and in the ER at Medical Center of Plano. | |Spring 2010 |Texoma Medical Center, Denison, Texas . Clinical rotation on ICU step-down unit with assignment in the...
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