...Organic Chemistry I Research Paper on Pseudoephedrine By: Natalie Roberts Jennifer Dargis Nakeesha Longeley Pseudoephedrine is a phenylethylamine which is utilized as a pharmaceutical product. It has the official IUPAC name of (1S,2S)-2-methylamino-1-phenylpropan-1-ol, and the CAS number of 90-82-4. Psuedoephedrine contains three functional groups: amine, hydroxyl, and ethyl in its ring; it also has one stereogenic carbon. The enantiomer of pseudoephedrine is ephedrine, and this substance can form two other diastereomers as well. Pseudoephedrine contains covalent bonds (both and double) and hydrogen bonds. A two-dimensional and three-dimensional structure are given below. [pic] [pic] Psuedoephedrine is also synthesized in various ways, sometimes with methods that add an amide to its structure in order to alter its medicinal effect. One of the most efficient techniques for synthesizing pseudoephedrine is given below: [pic] Reagents and conditions: (i) (CH2O)n, PTSA, benzene, reflux, 1 h; (ii) 1 equiv. NaBH4, MeOH, 2 h; (iii) PhMgBr, THF, 0°C–rt, 3 h; (iv) (CH2O)n, PTSA, benzene, reflux, 1 h; (v) NaCNBH3/TMSCl, CH3CN, rt, 30 min; (vi) conc. HCl, reflux, 2 h Pseudoephedrine is originally obtained as an alkaloid from the Oriental plant genus of Ephedra; as shown above, however, it can also be prepared artificially. The most common method of creating pseudoephedrine today is from yeast fermentation of dextrose in the presence of benzaldehyde. Typically...
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...Crystal Methamphetamine Use in First Nations Communities A Discussion Paper First Nations Centre May 2006 TABLE OF CONTENTS INTRODUCTION PART I CRYSTAL METHAMPHETAMINE: WHAT IS IT? WHO USES CRYSTAL METH HOW CRYSTAL METH IS USED HOW CRYSTAL METH IS MADE HOW CRYSTAL METH AFFECTS THE BODY, MIND, RELATIONSHIPS AND THE ENVIRONMENT PART II GOVERNMENT, ORGANIZED CRIME AND THE PHARMACEUTICAL INDUSTRY IN THE UNITED STATES CRYSTAL METH AND ILLEGAL DRUG STRATEGIES IN CANADA FIRST NATIONS AND CRYTAL METH TREATMENT STRATEGIES PART III TALA TOOTOOSIS’ STORY CRYSTAL METH ON THE NAVAJO NATION CONCLUSIONS APPENDIX A 1 INTRODUCTION Crystal methamphetamine 1 use among people in some First Nations communities (both in Canada and the United States) has evolved into an issue that is requiring more and more attention. Indicative of this, in July of 2005, the Assembly of First Nations (AFN) in Canada passed a resolution specifically directed at this emerging issue. 2 As a result of this resolution, the AFN has identified the need for the development of a First Nations National Task Force on Crystal Meth to develop a Strategic Action Plan to Address the Emerging issue of Crystal Meth in First Nations Communities. Generally speaking, this paper provides basic information about crystal methamphetamine as well as information that is First Nations specific. The first part of the paper discusses: what crystal meth is; who is using it; how it used; how it is...
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...Nations Communities A Discussion Paper First Nations Centre May 2006 TABLE OF CONTENTS INTRODUCTION PART I CRYSTAL METHAMPHETAMINE: WHAT IS IT? WHO USES CRYSTAL METH HOW CRYSTAL METH IS USED HOW CRYSTAL METH IS MADE HOW CRYSTAL METH AFFECTS THE BODY, MIND, RELATIONSHIPS AND THE ENVIRONMENT PART II GOVERNMENT, ORGANIZED CRIME AND THE PHARMACEUTICAL INDUSTRY IN THE UNITED STATES CRYSTAL METH AND ILLEGAL DRUG STRATEGIES IN CANADA FIRST NATIONS AND CRYTAL METH TREATMENT STRATEGIES PART III TALA TOOTOOSIS’ STORY CRYSTAL METH ON THE NAVAJO NATION CONCLUSIONS APPENDIX A 1INTRODUCTION Crystal methamphetamine 1 use among people in some First Nations communities (both in Canada and the United States) has evolved into an issue that is requiring more and more attention. Indicative of this, in July of 2005, the Assembly of First Nations (AFN in Canada passed a resolution specifically directed at this emerging issue. ) f 2 As a result o this resolution, the AFN has identified the need for the development of a First Nations National Task Force on Crystal Meth to develop a Strategic Action Plan to Address the Emerging issue of Crystal Meth in First Nations Communities. Generally speaking, this paper provides basic information about...
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...Community Health Advocacy Cherilynne Dator NUR | 544 January 14, 2013 Terry Kapfhammer Community Health Advocacy More than ever, thousands of young people experiment prohibited drugs. Whereas numerous of young teenagers by no means take their drug usage farther than the experimentation level, far too many will persist to absorb in this treacherous behavior until their drug abuse interrupts their lives. The most prevalent drugs of abuse among teenagers include alcohol, marijuana, and prescription drugs as well as common over-the-counter medications such as cough syrups containing pseudoephedrine and inhalants. This paper focuses on the drug abuse of prescription medications among teenagers from age 13 to 18 that has emerged as a public health concern and one that has evolved into epidemic levels. This seeks to elevate the visibility of the elapsed challenges, and problems associated with this epidemic. Prescription Medication Abuse: A Public Health Threat There is a compelling rationale that prescription medications are intentionally to be taken under the direction of a physician because if improperly consume these can be hazardous. Subsequently, teens are crafting decision to abuse prescription medications based on lack of information. In fact, numerous teens assumed that prescription medication abuse is safer than abusing illicit medications. Unfortunately, drug abuse pertaining to medication prescription is on the rise. This is the primary...
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...There is a lot of peer pressure in the world today for our children. Teenagers get approached just about every day by their peers to do something negative and many of them fall victim to it. Although this was given as an example, I find that it is a very significant problem that needs a breakthrough now. What I plan to do my paper on is teenagers and drugs. Drug use and abuse is bad for all parties involved (adults and teenagers). But it is really destroying our teens. Today it is so easy for teenagers to obtain just about any type of drug that they would want. These drugs include marijuana(also known as weed, pot, kush, loud, etc..), methamphetamine (also known as meth, crystal, christine, christina, speed, ice, etc…), cocaine, crack, herion, PCP, sherm, ecstasy or molly’s, and lastly a very long list of prescription drugs. Anything that has a way in causing addiction in my opinion is a problem and needs to be at the front of the line to be addressed especially when it comes to our children. Teens use to have to go out into the streets and search for the drug of choice, but today many of use parents are bringing the drugs right to them and into our homes and giving our children an in home supply without even knowing it. Yes the drugs are right there in our bathroom medicine cabinets, on our dressers, and even in our purses. They are also readily available at just about any store that sells cold medicine. Something needs to be done soon before...
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...stockton, california © 2009 American College of Clinical Pharmacy 1-281 General Psychiatry Learning Objectives: 1. Describe pharmacotherapeutic options for managing the following psychiatric problems: depression, bipolar disorder, schizophrenia, anxiety disorders, insomnia, and alcohol withdrawal. Describe the drugs used to treat the above disorders in terms of unique pharmacological properties, therapeutic uses, adverse effects, and cognitive and behavioral effects. Formulate a pharmacotherapeutic treatment plan when presented with a patient having depression, bipolar disorder, schizophrenia, an anxiety disorder, or insomnia. Discuss the treatment of substance abuse using alcohol abuse as a model. 4. 2. C. Theophylline. D. Pseudoephedrine. Which one of the following antidepressants would be least likely to cause drug-disease or drug-drug interactions for T.N.? A. Venlafaxine. B. Fluvoxamine. C. Phenelzine. D. Fluoxetine. Which one of the following periods represents the continuation therapy phase for T.N.’s depression? A. 6–12 weeks. B. 12–16 weeks. C. 6–12 months. D. 2−3 years. T.N. will be seen initially at monthly intervals to assess antidepressant therapy. Which one of the following instruments is a patient-completed measure of depressive symptoms that could be used to assess his response? A. Hamilton Rating Scale for Depression. B. Montgomery-Åsberg Depression Rating Scale. C. Beck Depression Inventory. D. Clinical Global Improvement Scale. Which one of the following...
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...4 : RECOMMENDATION AND CONCLUSION 42 REFRENCES 43 CHAPTER 1 : INTRODUCTION Errors are the result of actions that fail to generate the intended outcomes. In common with most other complex technical activities, human error is implicated in the majority of aviation-maintenance-related quality lapses, incidents, and accidents. General estimates of this human error contribution have increased over the years, from a low of around 20% in the 1960s to values in excess of 80% in the 1990s. Human error in aviation is somewhat of a sensitive topic due to the recent tragic events of September 11, 2001. The goal of this research is to understand human error in aviation, in order to understand how designing better computer systems can assist in making the aviation industry safer for pilots and passengers, by reducing human error. This paper does not attempt to address accidents caused by cowardly acts of terrorism. Many people do not know that on February 20, 1981 a modern Argentine jet airliner, with 58 people on board, almost crashed into the upper floors of the 110-story World Trade Center in New York (Grayson, 1988). The Argentine jet was put on a holding pattern in the New York area. The...
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...| New York City | Effective | 8 August 1975 [1] | Condition | 40 ratifications | Parties | 185[1] | Depositary | Secretary-General of the United Nations | Languages | Chinese, English, French, Russian and Spanish | Single Convention on Narcotic Drugs at Wikisource | The Single Convention on Narcotic Drugs of 1961 is an international treaty to prohibit production and supply of specific (nominally narcotic) drugs and of drugs with similar effects except under licence for specific purposes, such as medical treatment and research. As noted below, its major effects included updating the Paris Convention of 13 July 1931 to include the vast number of synthetic opioids invented in the intervening thirty years and a mechanism for more easily including new ones. From 1931 to 1961, most of the families of synthetic opioids had been developed, including drugs in whatever way related to methadone, pethidine, morphinans and dextromoramide and related drugs; research on fentanyls and piritramide was also nearing fruition at that point. Earlier treaties had only controlled opium, coca, and derivatives such as morphine, heroin and cocaine. The Single Convention, adopted in 1961, consolidated those treaties and...
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...United International University Department of Bachelor’s Business Administration (BBA) Course: Business Communication Section: G Report No: 03 Submitted to Course Instructor: Mrs. Rezwana Karim Senior Lecturer, School of Business United International University Submitted By: Name: Biplob Sarkar ID: 111092163 biplob_bsp@yahoo.com Date of Submission: 22th July 2010 Acknowledgement We are indebted to many people for providing us encouragement and support during our learning and working while making this project and we want to show our gratefulness to these people. We are very much grateful to Rezwana Karim, our respected course instructor of “Business Communication”, who assigned us this challenging project. She always guided us to take and overcome this challenge successfully. Without her help in every step it was quite impossible for us to finish this project properly in time. Thanks to the authority and the management of General Pharmaceuticals Ltd. for helping us in every possible way. Our cordial thanks to Mr. Monowarul Islam Bhuiyan, Deputy Manager of Sales Promotion at General Pharmaceuticals Ltd. in particular for his enormous help and assistance, for providing us the required information about their marketing and sales area and other facilities using his valuable time. At every moment we remember all of our friends and peers who encouraged and helped us a lot for long, in every stage of this project...
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...Contents 1. INTRODUCTION 9 1.1. Background: 10 1.2. Purpose statement 11 1.3. Limitations of research: 12 1.4. Main Research Questions: 12 1.5. Other research Questions: 12 1.6. HYPOTHESES 13 1.7. Population: 14 1.8. Research tool: 14 1.9. Methodology: 14 1.10. Scope of the research 15 2. LITERATURE REVIEW 16 2.1. TYPES OF DRUGS 17 2.1.1 Heroin 17 2.1.2 Cocaine 18 2.1.3 Methamphetamine 19 2.1.4 Crack Cocaine 20 2.1.5 LSD 21 2.1.6 Ecstasy 22 2.1.7 Opium 23 2.1.8 Marijuana 24 2.1.9 Psilocybin Mushrooms 25 2.1.10 PCP 26 2.2 DRUGS DUE TO DEPRESSION: 27 4.3 Peer Pressure and Drug Use 35 4.4 Drug enforcement agencies 36 4.5 Drug Trafficking in Pakistan 38 4.6 Statistics 40 5 Methodology 43 5.1 Questionnaire 44 5.2 INTRODUCTION 46 5.3 Research Findings 47 5.4 Data Analysis 51 6 CONCLUSION 65 6.1 Introduction 66 6.2 Recommendations 68 6.3 Bibliography 69 Letter of transmittal To: Sir Sheikh Irfan, business communication II From: Asad Ali Roomy, Mohammad Ali Qureshi, Mohammad Ali, Moaz Date: 8th December, 2012 Subject: Transmittal of report on “Use of drugs in our society” Respected Sir, We are pleased to submit, for your consideration, this report which has been prepared on our research, based on the perception of IoBM students regarding the use of drugs in our society. The research and survey was focused on analyzing the major factors that leads to the use of drugs and what can...
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...RESEARCH ON THE TRENDS IN DRUG ABUSE AND EFFECTIVE MEASURES FOR THE TREATMENT OF THE DRUG ABUSERS IN ASIAN COUNTRIES AN ANALYSIS OF INNOVATIVE MEASURES FOR THE TREATMENT OF DRUG ABUSERS PREFACE Crimes related to drug abuse and the illegal manufacturing and trafficking of drugs are serious problems for virtually every country. The abuse of drugs has an adverse impact, not only on the individual abuser, but also on the economy and society of a country as a whole. Drug use and the problems that accompany it have an extremely deleterious effect on the healthy development of young people, especially. Due to the rapid increase in drug related crime and drug abusers in Asian countries, the establishment of effective countermeasures for demand and supply reduction are a pressing issue. In light of the above-mentioned situation, the United Nations Asia and Far East Institute for the Prevention of Crime and the Treatment of Offenders (UNAFEI); and the Research Division of the Research and Training Institute, Ministry of Justice jointly conducted a comprehensive study on drug abuser treatment, from 2002 to 2004, entitled “Research on the Trends in Drug Abuse and Effective Measures for the Treatment of the Drug Abusers in Asian Countries - An Analysis of Innovative Measures for the Treatment of Drug Abusers”. The Asian countries included in the study are: China (Hong Kong), Korea, Malaysia, Singapore and Thailand. This is the first phase of the study on drug abuser treatment; the second...
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...CONTE N T S CHAI R M A N ’ S LETTE R DEAR SH AREH OL DERS FY2012 has been a good year for your Company. The key financial results were: ¥ Consolidated revenues increased by 30% to Rs. 96.7 billion in FY2012. ¥ Earnings before interest, taxes, depreciation and amortization (EBITDA)1 rose by 55% to Rs. 25.4 billion. ¥ Profit after Tax (PAT)2 grew by 45% to Rs. 15.3 billion. ¥ Diluted Earnings per Share (EPS) increased from Rs. 64.9 in FY2011 to Rs. 83.8 in FY2012. I am particularly delighted by four developments. First, your Company succeeded in yet another blockbuster generic launch in the USA under 180days marketing exclusivity. Dr. Reddy’s launched olanzapine 20 mg tablets, the generic version of the brand Zyprexa®. Olanzapine is used to treat schizophrenia and bipolar disorder. This product has added around USD 100 million to your Company’s revenues for FY2012. Second, the biosimilars business continues along its impressive growth path. In my letter to you last year, I had discussed the critical importance of developing biosimilars in the years to come. I am happy to note that your Company’s global biosimilars business grew by 45% over last year and recorded sales of USD 26 million. Today, the biosimilars portfolio of Dr. Reddy’s constitutes (i) filgrastim, (ii) peg-filgrastim, (iii) rituximab and (iv) darbepoetin alfa, which have commercial presence in 13 countries among emerging markets. These are helping to treat patients suffering from cancer — and at prices that...
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...Dream Dare Win www.jeywin.com Annual Report 2007-08 Ministry of Finance Government of India Dream Dare Win 1 www.jeywin.com Dream Dare Win www.jeywin.com FOR PUBLIC CONTACT PURPOSE: Ministry of Finance Department of Economic Affairs North Block, New Delhi - 110 001 Phones: 23095120, 23092453 Website: http://www.finmin.nic.in/the_ministry/dept_eco_affairs/index.html Department of Expenditure North Block New Delhi - 110 001 Phones: 23095661, 23095613 Website: http://www.finmin.nic.in/the_ministry/dept_expenditure/index.html Department of Revenue North Block New Delhi - 110 001 Phones: 23095384, 23095385 Website: http://www.finmin.nic.in/the_ministry/dept_revenue/index.html Department of Disinvestment Block 11 & 14, CGO Complex Lodhi Road, New Delhi -110 003 Phones: 24368528, 24368523, 24368044 Website: http://www.divest.nic.in Department of Financial Services Jeevan Deep Building, Parliament Street, New Delhi 110 001 Phones: 23748721, 23748734 Website: http://www.finmin.nic.in Dream Dare Win 2 www.jeywin.com Dream Dare Win www.jeywin.com Contents Paragraph No. INTRODUCTION Page No. 1 CHAPTER - I Department of Economic Affairs 9 Economic Division 1 11 Budget Division 2 12 Capital Markets Division 3 15 Infrastructure Division 4 19 Fund Bank Division (including UN Branch) 5 23 Foreign Trade Division 6 26 Aid Accounts & Audit Division ...
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...Handbook of Procedures (Vol. I) 27th August 2009 – 31st March 2014 w.e.f. 05.06.2012 Government of India Ministry of Commerce and Industry Department of Commerce Website: http://dgft.gov.in i ii TO BE PUBLISHED IN THE GAZETTE OF INDIA EXTRAORDINARY (PART-I, SECTION-1) GOVERNMENT OF INDIA MINISTRY OF COMMERCE AND INDUSTRY DEPARTMENT OF COMMERCE PUBLIC NOTICE No. 1 (RE-2012)/ 2009-2014 NEW DELHI, DATED THE 5th June, 2012 In exercise of powers conferred under Paragraph 2.4 of the Foreign Trade Policy, 2009-2014, the Director General of Foreign Trade hereby notifies the Handbook of Procedures (Volume I) and the Appendices to the Handbook of Procedures (Volume I). This shall come into force from 5th June, 2012. (Anup K. Pujari) Director General of Foreign Trade e-mail: dgft@nic.in (Issued from F. No. 01/ 61/180/0050/AM13/PC-3) iii iv CONTENTS CHAPTER SUBJECT PAGE GLOSSARY 1 1 INTRODUCTION 5 2 GENERAL PROVISIONS REGARDING EXPORTS AND IMPORTS 7 3 PROMOTIONAL MEASURES 53 4 DUTY EXEMPTION / REMISSION SCHEME 67 5 EXPORT PROMOTION CAPITAL GOODS SCHEME 125 6 EXPORT ORIENTED UNITS (EOUs), ELECTRONICS HARDWARE TECHNOLOGY PARKS (EHTPs), SOFTWARE TECHNOLOGY PARKS (STPs) SCHEME AND BIO- TECHNOLOGY PARKS (BTPs) 139 7 SPECIAL ECONOMIC ZONES 165 8 DEEMED EXPORTS 167 9 MISCELLANEOUS MATTERS 171 v vi GLOSSARY (ACRONYMS) Acronym ACC ACU AEZ ANF ARO ASIDE BG BIFR BOA BOT BRC BTP CBEC CCP CEA CEC CIF CIS CoD CoO CVD DA DoBT DC DEPB DFIA DFRC DGCI&S DGFT...
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...SU S AIN T ABI LI I M PA C T E EC ON OMIC S O CI A L & EN D R . R E D D Y ’ S L A B O R AT O R I E S L I M I T E D | A N N U A L R E P O R T | 2 0 0 9 – 1 0 RO VI V NM EN TA L • T Y • TI SI PO C R E AT I N G A C ONTENTS 24 MANAGEMENT DISCUSSION AND ANALYSIS 42 BOARD OF DIRECTORS 45 MANAGEMENT COUNCIL 72 DIRECTORS’ REPORT 2 CHAIRMAN’S LETTER 46 CORPORATE GOVERNANCE 89 IGAAP STANDALONE FINANCIALS 4 KEY HIGHLIGHTS 60 ADDITIONAL SHAREHOLDERS’ INFORMATION 70 FIVE YEARS AT A GLANCE 141 IGAAP CONSOLIDATED FINANCIALS 6 THE DNA OF SUSTAINABILITY 187 EXTRACT OF IFRS CONSOLIDATED FINANCIALS 190 STATEMENT PURSUANT TO SECTION 212 OF THE COMPANIES ACT, 1956 191 INFORMATION ON THE FINANCIALS OF SUBSIDIARY COMPANIES 192 NOTICE OF ANNUAL GENERAL MEETING 14 HUMAN RESOURCES 71 RATIO ANALYSIS 16 SAFETY, HEALTH AND ENVIRONMENT 18 CORPORATE SOCIAL RESPONSIBILITY 2 | S U S TA I N A B I L I T Y — C R E AT I N G A P O S I T I V E E C O N O M I C , S O C I A L A N D E N V I R O N M E N TA L I M PA C T CHAIRMAN’S LETTER 2009-10 has been a satisfactory year for your Company. Let me start with the financial results. Consolidated revenues for 2009-10 was Rs. 70,277 million. Excluding revenues from sumatriptan — your Company’s Authorized Generic version of Imitrex® which was launched in 2008-09 — revenue grew by 9%. In US dollar terms, 2009-10 revenue was US$ 1.56 billion. I am...
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