...suffers from pulmonary fibrosis, you know that it is a disease that occurs when the lung tissue becomes damaged and scarred, making it difficult to breathe. In most cases, the cause of the disease is not determined. When the cause is not found, the disease is referred to as idiopathic pulmonary fibrosis. Medications and therapies sometimes help lessen the symptoms, but pulmonary fibrosis is a progressive disease and the scarring worsens over time. COMPLICATIONS OF PULMONARY FIBROSIS There are a number of complications that can go along with this disease. 1. Pulmonary hypertension (high blood pressure in the lungs) Many people suffer from high blood pressure (hypertension), which is higher than normal pressure of the blood within the arteries. Pulmonary hypertension, however, is a condition that affects only the arteries in the lungs. Because of the scarring in the lungs, there is blockage and increased pressure in the arteries that causes a rise in the blood pressure....
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...There are a few fundamental assortments; 1] the confined mesotheliomabenign and threatening sorts 2] the diffuse dangerous mesothelioma Prompts We have a vigorous association concerning asbestos subjection and also the development with respect to mesothelioma, despite the fact that a brief history in regards to subjection isn't by and large available to be purchased in influenced people who may have mesothelioma. There are two sorts of asbestos muscle as indicated by crystalline development; a-serpentine chrysolite and b-amphibole. Coordinated inside of the amphibole are for the most part amosite, tremolte, crocidolite and anthophyllite. A standout amongst the most unsafe will be the crocidolite or possibly obviously better by and large known as orange asbestos. Limited Harmless Mesothelioma These sorts of typically happen on the internal level of the pleura Indicators and signs; - mid-section soreness - shortness with respect to air - the greater part of the events you will find not any signs and side effects asymptomatic, these sorts of tumors are by and large seen in timetable mid-section muscles x-beam - hypoglycaemia low glucose is here and there joined Cure Surgery will be the principle continue with respect to cure, the growth will be evacuated as a result of the specialist and reccurence will be bizarre and when this happens changeover keeping in mind the end goal to dangerous method for malignancy must be thought. Confined Malignant Mesothelioma Indicators...
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...Adult Client with Childhood Disease-Cystic Fibrosis Candace Tiley GCU RN-BSN Health Assessment NRS-434V Kathy Karlberg August 01, 2013 Adult Client with Childhood Disease-Cystic Fibrosis CLC GROUP ASSIGNMENT-SPEAKER NOTES Candace Tiley #1- A clinical description and definition of the disease Definition: Cystic Fibrosis is one of the major life-threatening disorders that affect vital organs such as the lungs, pancreas, liver, and intestines. It is a genetic disorder of the exocrine glands, also called the secretory glands, which are the glands that produce and secrete mucus and sweat. CF affects all races but primarily affects Caucasians of European descent. This disease affects about 30,000 people in the United States and 70,000 people worldwide. In the U.S. nearly 5% of the population carries the defective CFTR gene. There are a high number of asymptomatic carriers. (Scott, 2013) Cystic Fibrosis causes severe damages to cells of the body that produce mucus, sweat, and digestive juices. Under normal conditions, these secretions from the body are usually thin and slippery. However, in people diagnosed with CF, the defective gene causes the secretions to become thicker and stickier. This leads to a plugging up of tubes, ducts and passageways, particularly in the lungs, sinuses, pancreas, intestines, hepato-biliary tree, and the vas deferens. (Hopkin, 2009) Cystic Fibrosis is characterized by abnormal movement of chloride and sodium ions across the epithelial...
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...Current research on cystic fibrosis gene therapy suggests that it will become an important treatment strategy INTRODUCTION: Cystic fibrosis is an autosomal recessive disease, triggered by mutation in the gene CFTR i.e. cystic fibrosis transmembrane conductance regulator. CFTR is an ABC gene i-e ATP-binding cassette (transporter) gene that encodes a protein. This CFTR protein is a chloride ion channel protein that controls the flow of chloride ions and water across the cells. This movement is important in generating sweat, digestive juices, as well as mucus secretion and its clearance. This CFTR gene is located at q 31.2 locus of chromosome 7 long arm. The most common mutation in cystic fibrosis is removal of three nucleotides that results in loss of a nucleotide phenylalanine (F) at 508th position at the long arm of chromosome 7. Depending upon the protein expression and function six classes of mutations have been identified in cystic fibrosis: CLASS I: these are non-sense mutations that hinder the protein synthesis as they have premature stop codons. CLASS II: these mutations are most commonly found in patients of cystic fibrosis that include the deletions of phenylalanine 508th del. As a result of this deletion, protein folding is reduced and as a result its transport to cell surface is impaired and it undergoes degradation within the cellular lysosomes. CLASS III: in these mutations, proteins are normally present but are not expressed to a level that responds to intracellular...
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...Date: Introduction Cystic fibrosis (CF) refers to an inherited problem of the mucus glands. Mucus is a substance that is usually slippery secreted by the body to cover the digestive system, lungs, and reproductive system as well as other tissues and organs. CF makes the body to release excessive mucus that is extremely thick and sticky, which can cause various health issues. Among these health issues are difficulty in coughing, chest repetitive infections, lengthy diarrhea and deprived gain of weight. If the condition is not treated it would cause extensive complications, which may lead to early death. Nevertheless, if the condition is identified early and the child is exposed to proper treatment, the symptoms of CF are controllable and children may live longer. Different authors have different views on CF as they all try to get into a conclusion on how the health condition should be resolved. Since CF is inherited, the defective gene must be passed from both the parents to the child in order to acquire the disease else if only a faulty gene is inherited, the child becomes a carrier. Actually carries of cystic fibrosis do not have the disease but can pass to other individuals. There are proposals on improvements as well as challenges in executing the CF treatment process. The paper discusses the proposal below. Literature Review According to Norm Brown (2009), the gene responsible for CF was identified and it was named Cystic Fibrosis Trans-membrane Conductance Regulator...
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...Cystic Fibrosis Cystic fibrosis is a recessive, genetic illness, which affects the work of lungs, liver, intestine, and pancreas. This disease causes malfunctioning of the chloride and sodium transportation across the body and results in the thick and viscous secretions. Nowadays, cystic fibrosis affects thousands of people, especially in Europe and the US. Although, cystic fibrosis is a rare disease, it is quickly spreading all over the world and leads to the general shortage of life. In fact, it is a serious disease, which calls for an immediate diagnosis and appropriate treatment. History of the Disease Cystic fibrosis was discovered in the first half of the 20th century. However, without doubts, it emerged thousands of years before. The researchers surmise that cystic fibrosis appeared about 3000 BC, as a result of migration and gene mutation. During the 16-17th centuries, the salty taste of the skin (which is the symptom of cystic fibrosis) was considered a sign of bewitchment. Dr. Dorothy Andersen was the very first to describe the peculiarities and main characteristics of this disease. Before that investigation, the humanity had already known some facts and elements of cystic fibrosis. The reason for such late examination of this disease can be explained with the lack of required tools and means. Even nowadays, there are still many researches, aiming at providing objective information about cystic fibrosis and applying to the methods of the newborn and antenatal...
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...Cystic Fibrosis By Cameron Boulden Cameron Boulden BI101NB Cellular Essay Cystic Fibrosis Cystic Fibrosis is a genetic disorder passed down to children from parents through defective genes. Normally neither parent has the disease, it is the child who inherits one damaged gene from each parent, causing the infection. Some of the target areas for cystic fibrosis are, sex organs, lungs, liver, pancreas, and sinus. (Gary H. Gibbons) People living with cystic fibrosis have thick gluey mucus that builds up in their lungs and blocks the airways, ultimately making it hard for tubes to carry air in and out. Typically mucus is watery, keeping organs moisturized so they don’t dry out. (Gary H. Gibbons) Mutation of the CFTR (cystic fibrosis transmembrane conductance regulator) gene is what leads to cystic fibrosis. A change in this gene negatively affects the formation of the CFTR protein, making it unable to pass chloride ions and water in and out of cells. The lungs and pancreas are then directly...
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...Cystic Fibrosis The television must be turned up again to do another breathing treatment or it is time to get tapped before bed. I watch in awe as my little cousin sits there with a shaking vest on, and I wonder what is going on. If it’s time for another meal or if he just wanted a snack, he cannot forget to take his enzymes that he needs to aid in the digestion of food. I again start to wonder what is going on inside and how this little boy ended up with this disease, so I began my search in trying to learn as much about Cystic Fibrosis as I can. As of 2014, Cystic fibrosis (CF) infects about 70,000 people around the world and is known as the most common life shortening disease (Bell 2014). CF is the result of an offspring receiving two recessive alleles from each parent which comprise of a mutation inside the cystic fibrosis...
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...have been around for decades now. Its is not anything new. Cystic Fibrosis affects both the lungs and pancreas. Thousands, and millions of people have been diagnosed with CF worldwide. But, what are the causes and effects of Cystic Fibrosis? Cystic Fibrosis is a genetic disease that affects the lungs, pancreas, and gall bladder. CF also affects the respiratory and digestive system. The person with CF would have had to be born with a defective gene, which did not work correctly, causing thick mucus to build up in the lungs, pancreas, and gall bladder. The disease, CF was first described and named by Dorothy Anderson in 1938. Dorothy Anderson was born in Asheville, North Carolina, May 15, 1901. Dorothy had...
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...Cystic Fibrosis is a disease that for which one in every 25 Americans carry a gene, which means around 12 million Americans are carriers. It is caused by a mutation in the Cystic Fibrosis Transmembrane Conductance Regulator, causing an abnormal amount of mucus to be secreted, settling the lungs and pancreas. The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a protein that allows for chlorine ions to be able to escape mucus-producing cells. It helps thin out the mucus to keep the airways clear. When that gene is altered, it causes life-threatening harm to newborn babies, where most of them wouldn’t last longer than a couple of months. Due to the benefits of modern diagnosis and treatment, the life-span of a Cystic Fibrosis affected...
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...Cystic fibrosis, also known as mucoviscidosis, is an autosomal recessive disorder.1,2,22 It is the most common inherited disease in the Caucasian population affecting 1 in 3000 children in Western Europe.3 It is a multiorgan disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which is located on the long arm of chromosome 7 and encodes for a special chloride ion channel.4,5 The vast majority of mutations involve three or fewer nucleotides and result in primarily amino acid substitutions, frameshifts, splice site, or nonsense mutations.11 Of more than 800 identified CFTR mutations, the 3 base pair deletion of phenylalanine at position 508 is found worldwide in 70% of cystic fibrosis sufferers, therefore making F508 CFTR the most common deadly mutant in the Caucasian populations.6 Since cystic fibrosis has a genetic origin the opportunity to treat by replacing the defective gene with a normal healthy gene (gene therapy) offers a ‘novel therapeutic approach’ for sufferers.7 The estimated survival age of cystic fibrosis sufferers is 33.4 years (Fig 1). In this essay we will discuss the aetiology and symptoms of cystic fibrosis and the current available treatments, with particular emphasis on gene therapy and furanones, which prevent the build up of bacterial biofilms and thus reduce lung infection. Mutations in the CF gene can disrupt CFTR function within epithelial cells in different ways, ranging from complete loss...
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...mastered by birth. There’s nothing like not being able to breathe to persuade people to appreciate this simple, necessity. Cystic Fibrosis (CF) affects more than 30,000 children and adults in the United States, and 70,000 worldwide. (#7 about CF) Cystic Fibrosis is a chronic, autosomal recessive genetic disorder (#11 page 2). There is no cure for cystic fibrosis; as a matter of fact, it is a progressive disease and will only worsen over time.(#7 about CF). Everyone has a slippery substance (mucus) that lubricates and protects the linings of the airways, digestive system, reproductive system, and other organs and tissues in the body. Patients with CF have mucus that is abnormally thick, and sticky that no longer acts as a lubricant. This unhealthy mucus blocks the airways in the lungs causing permanent damage and loss of function, over time the digestive tract, mainly the pancreas is being clogged by this thick and sticky mucus, leading to malabsorption of food and nutrition in the intestine (#7 How CF may affect the body). Overall, understanding that Cystic Fibrosis is a genetic disorder with many complications, requiring constant testing to manage and treat the disease, while learning to live with CF to improve the quality of life. When it comes to cystic fibrosis, family matters, especially Mom and Dad. Every child inherits two CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) genes, one from each parent. CF occurs when a child inherits a faulty CFTR gene from each...
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...Cystic Fibrosis is “the most common genetic condition in North America” (How Stuff Works Contributors) and even more prevalent in the UK. “Approximately one in 29 Americans are carriers to Cystic Fibrosis and the condition occurs in approximately one in 3,000 live births in America.” (How Stuff Works Contributors) Cystic Fibrosis is caused by a defective recessive gene, the cystic fibrosis transmembrane conductance regulator(CFTR), carried by both parents and passed on to their offspring. It has varying degrees of severity and tends to get worse with age. Diagnosis of Cystic Fibrosis is usually caught in very early infancy or childhood. “Every state in the U.S. now routinely screens newborns for cystic fibrosis.” (Mayo Clinic Staff) The test...
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...Cystic Fibrosis Cystic Fibrosis is an inherited lifelong disease that affects more than 30,000 children and young adults in the United States (Kids Health, 2007).This genetic disease which affects the transportation and clearance of electrolytes and fluids across cell membranes from exocrine glands (Yourlunghealth.org, 2004). Exocrine glands are present everywhere in your body that comes into contact with an external environment. There is no cure for cystic fibrosis (Medline Plus, 2009). Cystic Fibrosis affects the lungs, pancreas, digestive tract and reproductive tract (American Lung Association, 2008). Cystic fibrosis mainly affects the lungs and pancreas. It causes the lungs to create thick, sticky mucus blocks in the airway making it very hard for the child to breath and also very easy for them to get infections. This can lead to tissue damage and airway inflammation (Yourlunghealth.org, 2004).Eventually the chest will assume a barrel shape with increase in size in the front and back of the child (Price and Gwin, 2008).In the pancreas mucus blocks prevent enzymes that help to break down food from reaching the intestines and aiding in digestion(Genetics Home Reference, 2009).Since the digestive tract cannot digest food properly this can lead to many problems, such as poor absorption of vitamins and minerals which can ultimately lead to malnutrition (Yourlunghealth.org, 2004). Kids with cystic fibrosis have trouble gaining weight even when they have a normal diet and a healthy...
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...According to the Cystic Fibrosis Foundation, cystic fibrosis (CF) is a fairly uncommon genetic disorder which occurs in approximately 70,000 people worldwide (n.d.-a). Although it is uncommon, the disease is fairly well known even in the general public. With advances in medicine, in both diagnosis and treatment of the disease, CF does not carry the death sentence it once did. As is the case with many diseases, people affected are living longer and more normal lives than they were able to in the past. Cystic fibrosis is a genetic disease which affects the mucous membranes as well as the sweat glands (Medline Plus, 2017). Cystic fibrosis is considered an autosomal recessive disorder, meaning that the child must inherit a faulty gene from...
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