...Targeted Therapy: A New Generation of Health Care Innovation Michael A. Kline University of Phoenix HCA/210 Introduction to Health Care Jon Lasell February 9, 2014 Targeted Therapy: A New Generation of Health Care Innovation Could targeted therapy be the “new” trend in fighting degenerative cancer genes that are affect nearly 13,000,000 people in the world? Scientific and technological advances and in the health care system have, and will continue to change as long as there are researchers willing and able to create new innovations for the continuum of care. There is no general definition for molecular or targeted therapy. Targeted therapy can block the growth and spread of cancer, thus preventing cancer cells from dividing or destroying. The idea behind this therapy is to create drugs that attack molecular pathways that cause disease, without upsetting the normal functions of other cells and tissues throughout the human body. The American Cancer Society list Breast cancer as the second cause of death in women, right behind brain and other nervous system cancers. Over, 2,000,000 women have been diagnosed with HER2 positive breast cancer, and this number will continue to rise and fall. Targeted therapy has already had a significant improvement for the outcomes for patients with HER2 positive breast cancer. However, Chemotherapy continues to be the mainstream way for cancer treatments because of evaluations on safety and ability from the drug combinations of...
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...To begin, this essay explores Glenilen yoghurts, a small artisan dairy business located in the heart of West Cork. Glenilen Farm is an artisan dairy products business located in the rural area of Drimoleague, County Cork which is run by Alan and Valerie Kingston. Alan’s family has been tending to the same small dairy farm in Drimoleague for generations. Nestled on the banks of the River Ilen, from which Glenilen have taken their name, Glenilen Farm is a perfect setting for dairy farming. The hills of Drimoleague, County Cork provide their cows with a rich and plenteous supply of healthy green grass, which in turn supplies Glenilen with the rich tasty milk, which has become the core and fundamental ingredient in all of their delicious products, in particular their yoghurts. In the past, Valarie Kingston enjoyed baking and experimented with her culinary skills using fresh, home-produced raw materials. It all started in 1977 when Valerie began using this milk to make homemade cheesecakes for country markets. Her cheesecakes, made with local fresh, simple ingredients, proved to be an immediate hit and quickly gained popularity and from that small beginning a very successful enterprise Glenilen Farm began. What started out as a pastime continued to thrive and grow, and in doing so transformed a small family dairy farm into a busy and buzzing enterprise. (Glenilen Farm Our Story, 2009) An old saying that perfectly sums up their business is ‘Good things come from small beginnings’...
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...Fall 15 Fall 15 Case II report Shasha Chen Professor: Dr. Maureen Mascha Date: 11/09/2014 Case II report Shasha Chen Professor: Dr. Maureen Mascha Date: 11/09/2014 08 Fall 08 Fall 1. Auditors should always evaluate the design and test the operating effectiveness of a company’s internal control. The key procedures of the evaluation of design are fulfilled by inquires, observations, and inspections. The same procedures can be used to test the operating effectiveness as well. Re-performance of controls is another method to test the operating effectiveness depending on different situations. Some of the key considerations related to the evaluation of design and the testing of operating effectiveness are summarized as follows: Information technology considerations Auditors should understand a company’s information technology (IT), including the system-generated data and reports, which are required by PCAOB. When assessing a company’s risk of material misstatement, auditors should pay great attention towards both manual and automated controls equipped by the company. Auditors should identify the control activities from the internal IT system performed by management. Just like the case stated, when testing the risk #1 and #2...
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...Introduction The use of software solutions to support business-critical processes has a decisive influence on the commercial success of the banks. At present, they are faced with the challenge of selecting optimal solutions to fit their particular needs, and implementing them. Information technology is indisputably crucial to the activities of financial service providers. A considerable proportion of funds should be spent on core banking systems, which provide indispensable support for bank-specific business processes. For some years now, banking software has been the source of lively debate. The advanced age of many business-critical systems, as well as their rigidity and complexity, have proven to be a burden to banks. Concern exists that they might no longer be able to meet the demands of today’s market. The triggers of this concern have been software systems that have been in use for a number of years and have been further developed over the course of time; in many instances they have been linked up – as effectively as possible – to bolt-on applications. Many core banking systems have grown up over the years that are lacking in the necessary flexibility, which has been compensated by workarounds. The technical problems that affected RBS Group has caused the banks to rethink their IT strategy. The transformation of the software environment is not merely giving banks the flexibility and agility they need. The use of appropriate applications also constitutes an effective...
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...13.387 Authenticate Pdf 2014 Minnesota Statutes Resources * ------------------------------------------------- Search Minnesota Statutes * ------------------------------------------------- About Minnesota Statutes * ------------------------------------------------- 2014 Statutes New, Amended or Repealed * ------------------------------------------------- 2014 Statutes Topics (Index) ------------------------------------------------- Chapter 13 * ------------------------------------------------- Table of Sections * ------------------------------------------------- Full Chapter Text ------------------------------------------------- Section 13.386 * ------------------------------------------------- Version List ------------------------------------------------- Recent History * ------------------------------------------------- 2006 13.386 New 2006 c 253 s 1 * ------------------------------------------------- 2013 Subd. 3 Amended 2013 c 82 s 3 * ------------------------------------------------- 2012 Subd. 4 New 2012 c 292 art 4 s 1 13.386 TREATMENT OF GENETIC INFORMATION HELD BY GOVERNMENT ENTITIES AND OTHER PERSONS. § Subdivision 1.Definition. (a) "Genetic information" means information about an identifiable individual derived from the presence, absence, alteration, or mutation of a gene, or the presence or absence of a specific DNA or RNA marker, which has been obtained from an analysis of: (1) the individual's...
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...Enron Case 10.8.2014 Melissa Becker Boya Du Sidi (Fiona) Chen Wei (David) Yu In June of 2001 Enron’s new CEO, Jeff Skilling, was heralded as the “No. 1 CEO in the entire country and Enron was saluted as “America’s most innovated company.” Just six months later, in December, Enron filed for bankruptcy. The failure shocked the public and angered investors. How could this have happened? Did no one see this coming? Where were the accountants? Where were the controls? Enron’s public troubles began on October 16th of 2001 when management released a third quarter earnings report with a “mysterious $1.2 billion dollar reduction.” The following month the company restated earnings for the previous five years and erased $600 million in profits. It turned out that the October report began to reveal Enron’s gross abuse of special-purpose entities (SPEs) and the mark-to-market accounting method. The company used SPEs to keep enormous amounts of losses off its books while inflating earnings from supply contracts by booking all profits from a contract in the quarter the deal was made. What also became clear was that Enron did not accomplish their gross manipulations without the help from their accountant’s at Arthur Andersen. Enron shareholders and executives were not the only groups negatively affected by Enron’s aggressive accounting practices. Arthur Andersen was also unraveled because of the role it played in Enron’s materially misstated financial statements. In a letter to...
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...Baskin Robbins Marketing Plan Final Outline Paper Lou Ann San Nicolas MKT 421 Marketing 1. Baskin Robbins Organizational Overview Baskin Robbins is a franchise based business operating in 35 countries for the last 65 years. The ice cream shops have more than 1,000 flavors since 1945. Baskin Robbins has more than 150 million consumers worldwide with 2,800 locations nationally and 5,800 stores globally. What began as a small business opportunity has grown into a solid business model for existing and future franchise business owners. Despite, by these two ice cream enthusiasts, whose passion leads to the creation of more than 1,000 ice creams flavors, and with a variety of delicious treats, such as nutty berry banana (Baskin & Robbins, 2011). The Baskin and Robbins business home office is situated in the area of Canton, Massachusetts. a. Organization Baskin Robbins Ice Cream Industry b. Mission Statement The philosophy and mission statement is eloquently put by a quote from co-founder Irv Robbins, “we sell fun, not just ice cream” (Robbins, 2011, p. 1). It is this statement that allowed Burt Baskins and Irv Robbins the opportunity to grow the business from one store to many. c. Geographic Locations The company had become an ice cream mega-empire, consisting of 5,800 stores in different geographical locations throughout the international. Exhibit 1.1 below shows the international geographic locations of Baskin Robbins industry (Baskin...
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...2011 Planning & Assessing RX 330 Productions for Toyota North America Team Charlie Oscar Oscar Lima AMBA 640, Section 9044 8/9/2011 Section I II III Executive summary Introduction Exercise 1: Toyota Production System (TPS) today TPS term definitions & practical examples IV Exercise 1: TPS as a total entity Advantages Limitations Evolution TPS use among other companies V Exercise 2: Grid analysis (Weighted scoring model) Exogenous factors & assumptions Endogenous factors & assumptions Constraints VI VII Exercise 2: Location recommendation Exercise 3: Decision tree analysis TMMC production capacity recommendation Limitations Past performance: RX 330/350 VIII Exercise 4: Current regional production strategy Assessment Change recommendations IX Summary Appendix A References Page 2 3 4 4 7 7 8 8 9 10 11 13 16 16 17 17 18 19 19 19 21 21 23 24 1 I. Executive Summary Toyota Motor Corporation is leading the way to future mobility through innovation, productivity, quality and efficiency. Toyota uses a self-developed strategy known as the Toyota Production System (TPS) to guide business process improvements. This strategy applies principles of “just-in-time” production, also called “lean”, to align supply closely with consumer demand while avoiding surplus inventory. The report defines eight TPS terms, i.e. jidoka, just-intime, hoshin, heijunka, muda, kaizen, standardized work, and pokayoke; and gives examples of how terms are applied in other industries...
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...Ensco PLC Company Analysis and Sell Report Nathan Green December 2, 2010 Finance 573 Dr. John Settle Rick Watson Contents Executive Summary 4 Company Overview 5 Sale Thesis 6 Energy Industry Overview (Oil and Gas Focus) 7 The “Upstream” Oil and Gas Sub-Sector Overview (Offshore Focus) 8 Macro-Level Trends in the Oil & Gas Industry 11 Industry Attractiveness Using Porters Five Forces 13 Bargaining Power of Suppliers: Low 13 Bargaining Power of Customers: Medium 13 Threat of New Entrants: Low 13 Threat of Substitute Products: High 14 Government Action: Medium 14 Competitive Rivalry: Medium 14 Five Forces Summary 14 Ensco’s Operations & SWOT Analysis 15 Strengths & Weaknesses 15 Opportunities & Threats 16 Financial Performance 17 Revenue, Cost of Sales, Net Income, & Margins 17 Capital Expenditures 18 Return on Assets 18 Relative Valuations 19 Financial Forecast 21 Discounted Cash Flow Valuation 22 Conclusion and Recommendation 23 Table of Figures Figure 1) World-Wide Energy Consumption Growth since 1965. 7 Figure 2) Example Photograph and Diagram of "Jackup" Oil Rigs 9 Figure 3) Example Photograph and Diagram of "Semisubmersible" Oil Rigs 9 Figure 4) Comparison of the Average Size of 2009 Oil Field Discoveries: Offshore vs. Onshore 10 Figure 5) Historical WTI Oil Prices 11 Figure 6) Historical and Projected Jackup Rig Demand 12 Figure 7) EIA Projected Global Demand for Energy...
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...Sistema Universitario Ana G. Méndez School for Professional Studies Florida Campuses Universidad del Este, Universidad Metropolitana, Universidad del Turabo MANA 321 Leadership and Supervision Supervisión y Liderazgo © Sistema Universitario Ana G. Méndez, 2007 Derechos Reservados. © Ana G. Méndez University System, 2007. All rights reserved. MANA 321 Leadership and Supervision 2 TABLA DE CONTENIDO/TABLE OF CONTENTS Páginas/Pages Prontuario/Study Guide .....................................................................................3 Taller Uno/Workshop One ................................................................................20 Taller Dos/Workshop Two ................................................................................23 Taller Tres/Workshop Three.............................................................................27 Taller Cuatro/Workshop Four ...........................................................................30 Taller Cinco/Workshop Five .............................................................................34 Anejo A/Appendix A..........................................................................................38 Anejo B/Appendix B..........................................................................................39 Anejo C/Appendix C .........................................................................................41 Anejo D/Appendix D ...........................................................
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...GMO MYTHS AND TRUTHS An evidence-based examination of the claims made for the safety and efficacy of genetically modified crops Michael Antoniou Claire Robinson John Fagan June 2012 GMO Myths and Truths An evidence-based examination of the claims made for the safety and efficacy of genetically modified crops Version 1.3 by Michael Antoniou Claire Robinson John Fagan © Earth Open Source www.earthopensource.org 2nd Floor 145–157, St John Street, London EC1V 4PY, United Kingdom Contact email: claire.robinson@earthopensource.org June 2012 Disclaimer The views and opinions expressed in this paper, or otherwise published by EOS, are those of the authors and do not represent the official policy, position, or views of other organizations, universities, companies, or corporations that the authors may be affiliated with. GMO Myths and Truths 2 About the authors Michael Antoniou, PhD is reader in molecular genetics and head, Gene Expression and Therapy Group, King’s Cols: lege London School of Medicine, London, UK. He has 28 years’ experience in the use of genetic engineering technology investigating gene organisation and control, with over 40 peer reviewed publications of original work, and holds inventor status on a number of gene expression biotechnology patents. Dr Antoniou has a large network of collaborators in industry and academia who are making use of his discoveries in gene control mechanisms for the production of research, diagnostic and therapeutic products...
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