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Research Paper On Osteomalacia

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Osteomalacia, a metabolic disease of calcium and phosphate
20 November 2015

Osteomalacia is decreased mineralisation of the bone caused by a deficiency of calcium serum in the blood, vitamin D, or a phosphorous deficiency. The body needs calcium serum for skeletal bone health as well as muscle and neuron action potential. Without enough calcium serum in the blood, the body responds by absorbing it from the small intestine, mobilizing calcium from the bones, and reabsorbing it from the kidneys (DeLuca, 2014). If the there is not enough calcium in the diet, the only source of calcium is the skeletal bones which leads to bone softening and weakening resulting in fragile bones prone to fractures. Osteomalacia can be indirectly caused …show more content…
If the kidney malfunctions or is absent and this process if limited, the body will have excess phosphate resulting in hyperphosphatemia (DeLuca, 2014). In this scenario, vitamin D synthesis would also be halted due to the release of FGF23 which inhibits 1α-hydroxylase in the kidneys. The excess phosphate ions in the blood quenches the calcium ions in the blood. When PTH is released to fix the state of hypocalcemia, there will be a high increase in resorption of the bones to release calcium into the blood, but this calcium will continue to be overwhelmed by the excess phosphate present. This will result in osteomalacia and will continue until treated with lowering the amount of phosphate in the diet and supplementing the active form of vitamin …show more content…
This is converted to previtamin D3 with the help of UV light. Previtamin D3 is then transported by vitamin D transport protein and converted into cholecalciferol, or vitamin D3. Vitamin D3 is then transported to the liver and converted to 25 hydroxyvitamin D3 via 25-hydroxylase found in the mitochondria, it is then transported to the kidneys. There it is converted by 1α-hydroxylase, found in the mitochondria, into 1α, 25 dihydroxyvitamin D3, or calcitriol. Calcitriol is the active form of vitamin D used in the body for calcium absorption in the small intestine. It also stimulates mobilization of calcium from the bone and increases reabsorption of calcium in the kidneys (Crenshaw et al.,

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