...Sickle cell anemia(SCD) is an inherited genetic disorder which causes the expression of defective hemoglobin on chromosome 11 resulting irregularly shaped red blood cells also known as “sickle cells” because they look like a sickle or are in a crescent shape. The normal red blood cells are round, smooth and deliver oxygen to cells throughout the body but a cluster of sickle shaped cells blocks the blood flow, causing painful attacks and sometimes stroke. Due to their different shape and chemistry, they are controlled by many free radical processes. This paper will talk about the frequency this disease, inheritance pattern, genetic changes, current research and/or efforts to develop vaccine, symptoms, diagnosis and treatment of sickle cell anemia....
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...Jimmy Lin Professor Robinson Biology 107 7 November 2015 Sickle Cell Disease A very common disease that is common in the United States is Sickle Cell. According to Genetics Home Reference, "Sickle cell disease is the common inherited blood disorder in the United States, affecting 70,000 to 80,000 Americans." I chose to research sickle cell because I thought it would be an interesting topic to research. Upon further research I found it intriguing the way the blood cells are shaped that cause so much pain and suffering to the human body. The pattern of inheritance of sickle cell is an autosomal recessive pattern. In order to receive sickle cell both parents must pass down the recessive gene. Many individuals today carry the gene and...
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...Sickle cell disease is caused by a seemingly negligible, but extremely life-threatening mutation in the patient’s hemoglobin protein. Hemoglobin (Hb) is a specialized protein within red blood cells that can carry oxygen. This protein consists of four subunits: two alpha units and two beta units. Each subunit contains one ferrous ion that can reversibly bind to one oxygen molecule. Thus, one Hb protein can bind to a maximum of four oxygen molecules. Red blood cells are specialized to contain as many Hb proteins as possible. When the blood with red blood cells flows to the lung, where oxygen concentration is relatively high, oxygen molecules can diffuse into the blood and bind to Hb proteins in the red blood cells. Then, when this oxygenated...
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...Sickle Cell Anemia Sickle Cell Anemia is a condition where it’s not enough healthy red blood cells, which carry adequate oxygen throughout your body. Normally our Red Blood Cells are flexible and round and move easily through the blood vessels. In Sickle Cell Anemia, the red blood cells get rigid and Sticky and they become shaped like a little crescent moon. The irregularly shape cells can get stuck in small blood vessels, which slows or blocks blood flow and oxygen to parts of the body. A way to tell how you have Sickle Cell Anemia is periodic pain, called crisis are a major symptom of Sickle Cell Anemia. This pain can last for hours or even weeks at a time. Painful swelling of hands and feet. Frequent...
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...one parent is a carrier of the recessive gene then the offspring could also become a carrier of the mutated gene. An example of a recessive inherited disorder is sickle cell disease. Sickle cell disease leads to chronic hemolytic anemia, pain, and organ failure due to abnormal hemoglobin....
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...report I want to talk about sickle cell anemia. Sickle cell anemia is a blood disease that changes the shape of the red blood cells from the circular shape to the shape of the crescent. The shape of the sickle changes into a crescent, which is difficult to pass through the small blood vessels. When this occurs, it is difficult to enter oxygen throughout the body. Hemoglobin is an iron-rich substance that makes blood red and allows red blood cells to carry oxygen from the lungs to all parts of the body. The abnormal hemoglobin causes red blood cells to be rigid, sticky and deformed. The father and mother must transmit the defective form of the gene in order for the child to be affected. If a parent transports the gene, the child will have some cells that have been...
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...it is very expensive and hard to obtain. Unfortunately, some families hide genetic disorders in their family and their offspring do not know to even be tested because the parents do not want them to know. Some of the most common genetic diseases are autism, some types of cancer, down syndrome, Osteogenisis imperfecta, cystic fibrosis, and sickle cell...
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...Josiah Hicks Genetic (Or Not) Disorders There are many diseases and disorders in the world, they all have different causes and effects. Some of the causes may be genetic, some might be the result of the surrounding environments, and some even remain unexplained. Today, I’m going to cover some of them, I’m going to explain the causes of the disorders, the resulting effects of the disorder, and if there is a cure. Sickle cell anemia or SCD is a hereditary disorder (meaning that it is acquired through the parents) and is categorized by the most prominent effect on the body’s production and storage of the a molecule in...
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...Sickle cell anemia is the most common form of sickle cell disease. Sickle cell anemia is rare but it can have a huge impact on the lives of the people that have it especially if they are athletes. There is a certain population that sickle cell anemia affects but the most common is African Americans. It can present with many different symptoms and can be very painful which makes it important for nurses to know what to look for when pain crisis occur. Sickle cell anemia is also important for a nurse to be educated on because there is a lot of patient education that goes with having sickle cell. There is no real cure for sickle cell because signs and symptoms can present differently in everyone that has it which makes educating patients on...
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...Sickle Cell Disease (SCD) is a blood disorder that affects more than 90,000 Americans. This condition is due to a genetic defect that mutates the structure of hemoglobin which is the oxygen carrying protein of red blood cells. Normal red blood cells are round like the letter “O” so they can move easily through the blood vessels. Red blood cells with the hemoglobin genetic defect have reduced oxygen carrying capacity. They are sickle-shaped like the letter “C” which reduces their ability to traverse small blood vessels. This can lead to blood clot formation in the capillaries and organ damage. There is no readily available cure for SCD but some children with the disease have been treated successfully with bone marrow transplants. High dose...
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...Abstract: Sickle cell anemia is an important world health problem that involves the genetic of our body where an an approximate of about 300,000 infants are born per year in the world, thereby posing it as an important factor for parenthood where it can easily be avoided. Acute, chronic, and acute-on-chronic complications contribute to end-organ damage and adversely affect the quality of life. (ncbi.nlm.nih.gov/pubmed2017) This article describes this disease it's vaso-occlusive crisis that occur in these patients with its treatment modalities and preventive measures. INTRODUTION Sickle cell anemia is a type of hemolytic anemia involving heamoglobinopathies of the human blood leading to a presence of a mutated form of hemoglobin with a sickle...
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...this paper, I will be looking at and reviewing the research literature that is available concerning sickle cells disease. I chose this topic for a reason that is close to my heart; I have an eight month old infant who has been diagnosed with sickle cell disease. As a professional, I am concerned with the ways that we as nurses can contribute to providing quality care in response to clients presenting with this specific disease. As a person, I am on the other side of the health promoting, family based care relationship that I am used to in my practice; I now really appreciate how important it is for nurses to provide education, information, teaching and training to parents and clients in response to an illness like sickle cell. In a way, therefore, I am serving both as teacher and student here, as I develop knowledge and collect evidence that I will use as both a nurse and as a concerned parent seeking to understand a disease that my child has been diagnosed with. This literature review supports the argument that nurses can play an important role in promoting quality care for clients and families coping with sickle cell disease, once a strong understanding of this disease and the nurse’s role in responding to it is achieved. This, therefore, is the goal of this literature review. Gale’s “Health Reference Centre Academic” database was used for the research. In fact, a very simple search resulted in the obtainment of all six of the quality, peer reviewed, scholarly research articles...
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...This paper will describe what sickle cell anemia is, how it effects the human body; as well as the oral cavity. Sickle cell anemia is a hereditary disease caused by abnormal hemoglobin, which causes the red blood cells to have low oxygen levels (National Heart, Lungs and Blood Institute, 2015). Sickle cell anemia is inherited only if both parents have the disorder because it is caused by the genetic abnormality of hemoglobin (webMD, 2015). When there is abnormal hemoglobin it can produce sickle hemoglobin (webMD, 2015). This causes the red blood cells to stick together and create long rod shaped red blood cells when oxygen leaves the cell (webMD, 2015). When this happens it causes the symptoms of sickle cell anemia (webMD, 2015). In people...
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...Sickle Cell Disorder Research Paper Sickle cell anemia is a disease passed down through families in which red blood cells form an abnormal sickle or crescent shape. Red blood cells carry oxygen to the body and are normally shaped like a disc. Sickle cell disease refers to a group of inherited red blood cell disorders. It is the most common genetic disease in the U.S. An estimated 70,000-80,000 Americans have sickle cell disease. Normal red blood cells are round like doughnuts, and they move through small blood tubes in the body to deliver oxygen. Sickle red blood cells become hard, sticky and shaped like sickles used to cut wheat. When these hard and pointed red cells go through the small blood tube, they clog the flow and break apart. This can cause pain, damage and a low blood count, or anemia. What is sickle cell trait? A person with the sickle cell trait does not have (and will never have) sickle cell disease. However, the presence of the trait may impact his/her children How do you get sickle cell disease? Sickle cell disease is not contagious; you cannot "catch" it. You inherit it from your parents. If, for example, one parent has normal hemoglobin ( type AA) and the second parent has abnormal hemoglobin ( type AS, or the sickle cell "trait"), there is a 50% chance that each child will have the sickle cell trait, but they will not have sickle cell disease ( type SS). The three most common forms of the disease in the United States are: 1. Hemoglobin...
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...Eastern Shore Sickle Cell Anemia Dayona Williams Developmental Psychology 0301 Evelyn Jones 25 November 2014 Abstract: The paper you are about to read will inform you about the disease Sickle cell Anemia. It will explain to you about what Sickle cell Anemia is and how you develop it. This paper will also tell you the symptoms and who can get it. While reading the information you will understand all about the disease and how it’s treated and can it be cured. Also in the paper it will inform you about the difference in Sickle cell Anemia and Sickle cell Trait. Lastly, In the paper you are about to learn all you need to know if someone in your family has Sickle cell Anemia and what they go through and how to actually understand it. In today’s society many kids and adults face the disease called Sickle-cell Anemia. This disease is well known throughout many states and countries. Sickle-cell Anemia is when red blood cells are not shaped as normal blood cells. They are shape in a crescent moon like shape which creates different blockages from the normal cells to pass through. The reason why is because the actual sickle cells become sticky to the point where they stick on the blood vessels wall. Many people know that red blood cells carry nutrients and oxygen from the lungs throughout the body. With the blood vessels flow being blocked and the blood cells shape being crescent there is not enough oxygen being pushed through the body. The red blood cell also carries, “iron...
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