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Spironolactone Research Paper

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Background and History
Spironolactone is a light cream colored stable powder that has a faint odor.1 It is available in 25 mg tablets that are round, film coated, and a light yellow color.2 Spironolactone was created by G.D. Searle and is currently the only product that directly treats hyperaldosteronism, the excess production of aldosterone in the body.3 Spironolactone goes by several trade names including Aldactone and Spironolone, which are also common. Spironolactone is in the aldosterone-receptor blockers medication category. Spironolactone is a diuretic mostly used to treat hypertension and edemas.4 The discovery that led to the development of spironolactone was aldosterone being found to be the third hormone in the adrenal cortex. Aldosterone …show more content…
The first major breakthrough came in 1953 from the work of Reichstein who discovered how to isolate aldosterone.5 After discovering that aldosterone caused edemas that could lead to other conditions, there was a research phase to develop an antagonist for the aldosterone receptor.3 Spironolactone was first given to rats and showed …show more content…
Spironolactone acts as a diuretic by excreting excess sodium and water, but potassium remains in the body. Spironolactone can be given with other diuretic medications to have an increased effect. Increased amounts of aldosterone, a mineral corticosteroid, and causes primary and secondary hyperaldosteronism. Primary hyperaldosteronism can lead to hypertension and secondary hyperaldosteronism can lead to heart conditions, such as heart failure, and edemas. Spironolactone is effective in treating hypertension from primary hyperaldosteronism. Spironolactone acts primarily at the collecting tubule in the kidneys, but can also act in the heart.3 Aldactone, one of the main components of spironolactone, is quickly absorbed into the body and along with the sulfur components is a main reason for the effectiveness of the drug. Food increases the absorption of the drug and is excreted mainly through urine and partially bile.2 Spironolactone is metabolized into many metabolites, including the two most important in relation to pharmacology, canrenoate and canrenone. Several of the metabolites derived from spironolactone also have biological activity, including canrenone and

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