...DRUG DEVELOPMENT SCIENCE Obstacles and Opportunities for Collaboration Among Academia, Industry and Government January 13–14, 2005 Washington, DC David Korn, M.D. Donald R. Stanski, M.D. Editors DRUG DEVELOPMENT SCIENCE Obstacles and Opportunities for Collaboration Among Academia, Industry and Government Report of an Invitational Conference Organized by The Association of American Medical Colleges Food and Drug Administration Center for Drug Development Science, at the University of California, San Francisco January 13-14, 2005 Washington, DC David Korn, M.D. Donald R. Stanski, M.D. Editors DRUG DEVELOPMENT SCIENCE ACKNOWLEDGEMENTS This is the report of a conference convened by the Association of American Medical Colleges and the Food and Drug Administration in response to the FDA white paper entitled “Innovation or Stagnation: Challenge and Opportunity on the Critical Path to New Product Development”. The conference was partially supported by the FDA. The AAMC acknowledges with gratitude the additional support provided by Abbott Laboratories, Cephalon, Inc., Eli Lilly and Company, GlaxoSmith Kline, Merck & Co. Inc., and Pfizer, Inc. The conference planning committee consisted of Drs. David Korn, Joel Kupersmith, Carl Peck, Donald Stanski, and Janet Woodcock. Figures 1 and 2 are taken from the FDA white paper. The back cover composite is derived from charts presented at the conference by Dr. Peter Corr, Pfizer, Inc. The report was designed by Douglas Ortiz, AAMC...
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...responsibilities relative to meeting course competencies. * Relate course/clinical assignments and evaluation * Distinguish how the major concepts (see Nursing Student Handbook) of the program are affected by the variety of conditions and diseases within this course for all age groups. Outline A. Orientation to course 1. Course descriptions 2. Course outcomes/competencies 3. Textbooks B. Course Requirements 1. Student assignments and responsibilities 2. Minimum level of achievement 3. Evaluation tools C. Course/ Clinical Assignments and Evaluation D. Major Concepts 1. Caring 2. Clinical judgment, clinical reasoning, and nursing judgment 3. Clinical microsystem 4. Collaboration 5. Critical thinking 6. Cultural competence and Diversity 7. Ethics 8. Evidence-based care 9. Healthcare environment 10. Human flourishing 11. Informatics and Information management 12. Integrity 13. Knowledge, skills, and attitudes 14. Leadership 15. Nursing and Nursing Process 16. Nursing-sensitive indicators 17. Patient and Patient-centered care 18. Personal and Professional development 19. Professional identity 20. Quality improvement 21. Relationship-based care 22. Safety Teaching-Learning Strategies * Review course syllabus distributed by instructor * Read requirements and policies related to program found in Nursing Student Handbook (NSH) * Review course...
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...cs Table Contents……………………………………………………………………………………………………………….1 Summary 2 Literature review 5 Biological applications of bioinformatics 5 Real world application of bioinformatics 6 Conclusion 9 References 10 Summary Bioinformatics is a field in biotechnology that involves the application of technology involving computers to manage and analyze biological data. In this, computers are used in gathering, storing, analysis and the merging of biological data. Bioinformatics is not a research area by itself but lies between biological sciences and computational sciences. The main goal of bioinformatics is to review the value of biological information that is hidden in the large amount of data come up a clear picture of the basic biology of organisms. There are several fields that have been revolutionized by the technology used in bioinformatics (Ouzounis & Christos, 2012). These fields include human health, the environment, agriculture, energy and biotechnology. This science of bioinformatics is also called computational biology and has found a lot of use in increasing the quality of life. Bioinformatics developed due to the great need to internalize the DNA which is the code of life. Growth in the field of bioinformatics has been facilitated by development of many DNA sequencing projects. The basic biology of life is controlled by the basic molecule of life called DNA. The DNA acts as the blue print for genes which code for proteins. The proteins coded for...
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...Applied Statistical Methods Larry Winner Department of Statistics University of Florida February 23, 2009 2 Contents 1 Introduction 1.1 Populations and Samples . . . . . . . . . . . 1.2 Types of Variables . . . . . . . . . . . . . . . 1.2.1 Quantitative vs Qualitative Variables 1.2.2 Dependent vs Independent Variables . 1.3 Parameters and Statistics . . . . . . . . . . . 1.4 Graphical Techniques . . . . . . . . . . . . . 1.5 Basic Probability . . . . . . . . . . . . . . . . 1.5.1 Diagnostic Tests . . . . . . . . . . . . 1.6 Exercises . . . . . . . . . . . . . . . . . . . . 7 7 8 8 9 10 12 16 20 21 25 25 29 29 29 32 32 32 32 32 35 35 37 38 38 39 40 42 42 44 48 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Random Variables and Probability Distributions 2.1 The Normal Distribution . . . . . . . . . . . . . . . . . . 2.1.1 Statistical Models . . . . . . . . . . . . . . . . . 2.2 Sampling Distributions and the Central Limit Theorem 2.2.1 Distribution of Y . . . . . . . . . . . . . . . . . . 2.3 Other Commonly Used Sampling Distributions . . . . . 2.3.1 Student’s...
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...PROJECT-1 “MARKET ANALYSIS & PERCEPTION ON PRE-PROBIOTICS” PROJECT-2 “MARKET ANALYSIS & PERCEPTION ON FERROUS ASCORBATE” A PROJECT REPORT Submitted By GAYATRI .P. PAWAR Roll No. 35 In Partial Fulfilment For The Award Of The Diploma Of PGDM IN PHARMACEUTICAL MANAGEMENT PROJECT GUIDE: INTERNAL GUIDE : MR .KAPIL.MUDLIAR MRS.SUMANA BOSE (PRODUCT MANAGER) (FACULTY) DUPEN LABORITIES PVT. SIESCOMS. S.I.E.S COLLEGE OF MANAGEMENT STUDIES MAY 2010 - JUNE2010 DECLARATION I hereby declare that the project work entitled “MARKET ANALYSIS AND PERCEPTION ON PRE-PROBIOTICS” –PROJECT 1 MARKET ANALYSIS AND PERCEPTION ON LATEST HEMATINIC (FERROUS ASCORBATE+ FOLIC ACID)- PROJECT 2 submitted to SIES COLEGE OF MANAGEMENT STUDIES, NERUL NAVI MUMBAI is a record of an original work done by me under the guidance of Mrs.SUMANA BOSE, Faculty Member,and Dr. Suhas Tambe ,HOD. this project work has not performed the basis for the award of any Degree or diploma/ associate ship/fellowship and similar project if any. GAYATRI PAWAR ABSTRACT The main goal of the report was to investigate about the PRE-PROBIOTICS molecule, its...
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...Name And Student Number (Bolded)Course, Semester, Year | SITI ROHAIDA BINTE RAHMAT12B057ZADVANCE DIPLOMA IN NEUROSCIENCE, 2012 | Managing Client with Cerebrovascular Disease Introduction Stroke is a part of a cardiovascular disease that occurs when the supply of blood or oxygen to the brain is disrupted by a blockage in the artery or when there is usually a trauma that causes spontaneous bleeding in the brain (Duncan, Zorowitz & Lambert, 2005). Bleeding in the brain, is referred to as a haemorrhagic stroke which results from either ruptured blood vessels or due to an abnormal vascular structure such as arterio-venous malformation. Although stroke can be classified into two different categories (ischemic and haemorrhagic), one should note the indispensable relationship between the two. This would be later explained at a greater detail into the case study. The following would be a brief introduction of my chosen case study. Emergency Department A 22 year old gentleman was brought to the Emergency Department at 1235hrs on 28th October 2012 via ambulance. Patient was unresponsive upon arrival, GCS= 3, E1V1M1, bilateral pupils non-reactive to light and slight epistaxis noted. History obtained from eye-witnesses stated that patient just finished boxing practice and complained of severe giddiness before fainting shortly after and never regained consciousness. On arrival at Emergency Department, patient was sent for a CT (computed tomography) Brain with chest and cervical...
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...ENHANCEMENT OF VETERINARY TRAINING AT THE AHMADU BELLO UNIVERSITY, ZARIA. A PROPOSAL FOR THE REVIEW OF VETERINARY EDUCATION AT THE AHMADU BELLO UNIVERSITY TO FACILITATE LINKAGES WITH THE KANSAS AND IOWA STATE UNIVERSITIES IN THE UNITED STATES OF AMERICA HASSAN, Adamu Zoaka MARCH 2011 1.0 INTRODUCTION When Ahmadu Bello University (ABU) was established in 1962, it was decided to give particular attention to Agriculture and Veterinary Medicine. Therefore, in 1964, the Faculty of Veterinary Medicine was established at ABU following the signing of an agreement between the government of the Federal Republic of Nigeria and the United States Agency for International Development (USAID) and the Kansas State University (KSU). According to this agreement, KSU/USAID was to provide initial staff and equipment to the new Faculty to enable it develop the following: (a) a well-equipped Veterinary School to train and supply Veterinarians for Nigeria and the rest of West African countries; (b) a postgraduate training programme in Veterinary Medicine; (c) a research programme to improve Animal Health, production and Public Health in Nigerian; (d) train Nigerians to staff and assume major roles in the Faculty of Veterinary Medicine as soon as possible; and; (e) advise on facilities and programme for future development and expansion of the Faculty. Professor G.K.J.L. Underberg (Kansas State University) arrived on September 15, 1964 as the first Dean of the...
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...e-mail and Web addresses Date Prepared January 200B Enter Month and Year Insert your company’s disclaimer and confidentiality notice. Consult with your attorney as to the wording. The information contained herein is furnished on the condition that it is solely for internal use, for evaluation and planning purposes only, and this information shall not be disclosed, duplicated, used in whole or in part, for any other reason whatsoever. TABLE OF CONTENTS To jump directly to any title listed in the Table of Contents, hold down CTRL and then click the title. TABLE OF CONTENTS 2 Executive Summary 5 The Company 5 The Market 5 Competitive Analysis 5 The Product/Service 5 Value Proposition 6 Marketing and Sales Plan 6 Management and Organization 6 Financial Summary 6 Investor Summary 6 The Company 8 Name and Location 8 Facilities 8 Legal Form of Business 8 Employees 8 Company History 8 Marketing Plan 9 Industry Profile 9 Current Size 9 Growth Potential 9 Industry Trends 9 Other Characteristics 10 Sales Channels 10 Competitive Analysis 11 Direct Competition 11 Indirect Competition 11 Future Competition 11 Competitive Analysis 11 Market Analysis 12 Target Market Profile 12 Customer Profile 13 Future Markets 14 Product/Service Plan 15 Purpose of Product/Service 15 Features and Benefits...
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...e-mail and Web addresses Date Prepared January 200B Enter Month and Year Insert your company’s disclaimer and confidentiality notice. Consult with your attorney as to the wording. The information contained herein is furnished on the condition that it is solely for internal use, for evaluation and planning purposes only, and this information shall not be disclosed, duplicated, used in whole or in part, for any other reason whatsoever. TABLE OF CONTENTS To jump directly to any title listed in the Table of Contents, hold down CTRL and then click the title. TABLE OF CONTENTS 2 Executive Summary 5 The Company 5 The Market 5 Competitive Analysis 5 The Product/Service 5 Value Proposition 6 Marketing and Sales Plan 6 Management and Organization 6 Financial Summary 6 Investor Summary 6 The Company 8 Name and Location 8 Facilities 8 Legal Form of Business 8 Employees 8 Company History 8 Marketing Plan 9 Industry Profile 9 Current Size 9 Growth Potential 9 Industry Trends 9 Other Characteristics 10 Sales Channels 10 Competitive Analysis 11 Direct Competition 11 Indirect Competition 11 Future Competition 11 Competitive Analysis 11 Market Analysis 12 Target Market Profile 12 Customer Profile 13 Future Markets 14 Product/Service Plan 15 Purpose of Product/Service 15 Features and Benefits...
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...Personal ID: C3735427 Name: Erika Azzopardi Assignment number: Tutor marked assignment 03 (TMA03) - Cancer Module: S807 - Molecules in medicine Question 1a Figure 1: Summary of the cell cycle illustrating: G1; S; G2 and M phases. Cells grow and prepare to synthesize DNA in the G1 phase. Cells move towards end of G1 phase to pass through G1-checkpoint. G1-checkpoint determines if a cell is suitable for cell division by checking for damaged DNA. On check completion, cells owning undamaged DNA move to the S phase. Cells with damaged DNA are arrested and "commit suicide" via apoptosis. Proto-oncogenes are normal genes which produce signals to guide a cell to divide or ‘commit suicide’. These genes are inspected by checkpoints. When proto-oncogenes...
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...Benziodiazepine Drugs: Comparison of Diazepam, Clonazepam, & Lorazepam Table of Content Page 3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Introduction Page 4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: History & Mechanism of Action Page 5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Pharmacokinetics Page 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Comparison of Pharmacokinetics Page 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Comparison of Pharmacokinetics Page 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Comparison of Pharmacokinetics Page 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Adverse Effect Page 10 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Overdose Page 11 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Diazepam: Contradiction Page 12 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clonazepam: Information & Mechanism of Action Page 13 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clonazepam: Pharmacokinetics Page 14 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clonazepam: Comparison of Pharmacokinetics Page 15 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Clonazepam: Comparison of Pharmacokinetics Page 16 . . . . . . . . . . . . . . . . . ...
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...African Journal of Pharmacy and Pharmacology Vol. 4(6). pp. 324-329, June 2010 Available online http://www.academicjournals.org/ajpp ISSN 1996-0816 ©2010 Academic Journals Full Length Research Paper An investigation into students’ study habit in volumetric analysis in the senior secondary provision: A case study in Ondo State, Nigeria Orimogunje Tunde1, Oloruntegbe Kunle Oke2 and Gazi Mahabubul Alam3* 1 Science and Technical Education Department, Adekunle Ajasin University, Akungba-Akoko, Nigeria. 2 Mathematics and Science Education Department, University of Malaya, Kuala Lumpur, Malaysia. 3 University of Malaya, Kuala Lumpur, Malaysia. Accepted 14 May, 2010 An investigation was carried out on students’ study habit in volumetric analysis at the senior secondary school level in Ondo State. A descriptive research design was adopted in the study. Questionnaire on study habit inventory was adapted and used to collect information from the respondents at various sampled schools. The sample comprised 240 senior secondary II chemistry students drawn from six schools in Akure South Local Government Area of Ondo State. The hypotheses investigated with respect to students’ study habit problems such as home work/ assignment, reading and note-taking, students’ concentration, time allocation, teachers’ consultation as human variables were analyzed using chi-square statistics at 0.05 level of significance. The results indicated that the main sources of students’ study problems have strong...
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...European Medicines Agency, 2008. Reproduction is authorised provided the source is acknowledged. TABLE OF CONTENTS 1 BACKGROUND INFORMATION ON THE PROCEDURE................................................... 3 1.1 Submission of the dossier ...................................................................................................... 3 1.2 Steps taken for the assessment of the product........................................................................ 3 2 SCIENTIFIC DISCUSSION......................................................................................................... 5 2.1 Introduction............................................................................................................................ 5 2.2 Quality aspects ....................................................................................................................... 5 2.3 Non-clinical aspects ............................................................................................................... 9 2.4 Clinical aspects .................................................................................................................... 23 3 OVERALL CONCLUSIONS, RISK/BENEFIT ASSESSMENT AND RECOMMENDATION............................................................................................................... 55...
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...Marriage Guidance – Summary MGG201W MGG201W – Marriage Guidance – facilitative couples counselling Theme ONE – Understanding couples Intimacy involves: love, affection and caring, deep attachment to another person. The TRIPOD of couple relationships An intimate relationship consists of three factors that form a tripod on which the relationship rests. 1. Passionate attraction (PA) 2. Mutual expectations (ME) 3. Personal intentions (PI) Passionate attractions (PA) → Individual experiences intensely pleasurable sensations when thinking about or being with a new partner. → Blushing, trembling, breathlessness, high sexual desire → Referred to as infatuation = passing love “a foolish and unreasoning love’ → Infatuation is not a realistic / accurate appraisal of the relationship / idealisation → Negative / flaws in the idealised beloved may be intellectually recognised, but disregarded as endearingly special. Person chooses to ignore the negatives → Normal phase in the process of relationships → Infatuation can lead to a lasting relationship – but it mostly fades away and relationship based on infatuation alone will fail. Love → Involves physical attraction - deeper → Love encompasses PA, ME and PI → People rely mostly on life experiences to guide them to their own unique way of demonstrating love. → Eric Fromm “love is active concern for the life and growth of the person we love” → Love is deep, unselfish, caring, deep respect Hauck’s basic principles about love • It is not just...
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...Fundamental of Criminology Investigation - an inquiry, judicial or otherwise for the discovery and collection of facts concerning the matters involved. - it is the process of inquiring, eliciting, soliciting and getting vital information, facts, circumstances in order to establish the truth. Criminal Investigator - a public safety officer who is tasked to conduct the investigation of all criminal cases as provided for and embodied under the revised penal code, criminals laws and special laws which are criminal in nature. - a well trained, disciplined and experienced professional in the field of criminal investigation. Custodial Investigation - investigation conducted by law enforcement officers after a person has been arrested or deprived of his freedom of action. Neighborhood Investigation - one of the most crucial steps in kidnap for ransom cases which is often overlooked. The objective is to identify and interview in person all individuals in the area where the victim was kidnapped or last known sighting area during the window of opportunity.(last time seen until the time discovered missing. Crime scene - a venue or place where the alleged crime/incident/event has been committed. Corpus delicti - (latin for the body of the crime) - used to describe the physical or material evidence that a crime has been committed. ex. corpse of a murder victim. Confession - is an express acknowledgement by the accused in...
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