...Disease Achondroplasia is the most frequent form of short-limb dwarfism (Nahar R et al 2009). As well as short stature due to shortening of limbs, affected individuals have characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum and trident-like hands. Incidence increases with paternal age. Achondroplasia is caused, in virtually all of the cases, by a G380R mutation in fibroblast growth factor receptor 3 (FGFR3) (Di Rocco F et al 2014). FGFR3 is also important in craniofacial, vertebral and neurological development such that this mutation has multiple effects in an affected individual (Horton WA et al 2007). Clinical Presentation Gross motor development frequently is delayed. Motor milestones such as head control and independent sitting, standing, and ambulation may lag by 3-6 months. Speech and language problems may be caused by tongue thrust (due to abnormal maxillomandibular relationship) but often resolve spontaneously. Twenty percent of patients experience delayed speech acquisition. Cognitive skills are preserved, and the intelligence level is within normal limits. Cranial enlargement and poor head control place the infant at risk for extension injuries. An Australian study assessed the functional milestones of achondroplasia children aged 3-7 years. The data noted that while milestones were delayed across all ages studied, functioning improved between age 3 and 5 years, although not...
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...Critically Appraised Paper Activity Analysis Adeline Pierre OTR 625: Advanced Clinical Reasoning Barry University Dr. Beckley August 22, 2010 CRITICALLY APPRAISED PAPER (CAP) WORKSHEET CITATION: Moraska, A., Chandler, C., Edmiston-Schaetzel, A., Franklin, G., Calenda, E., & Enebo, B. (2008). Comparison of a targeted and general massage protocol on strength, function, and symptoms Associated with carpal tunnel syndrome: a randomized pilot study. Journal Of Alternative And Complementary Medicine (New York, N.Y.), 14 (3), 259-267. Retrieved from MEDLINE database. | FOCUSED QUESTION: Can massage therapy be an effective conservative intervention method for the treatment of carpal tunnel syndrome? | PROBLEM STATEMENT (JUSTIFICATION OF THE NEED FOR THE STUDY): Carpal tunnel syndrome is the most reported nerve compression syndrome. The cause of this syndrome is due to fibrotic tissue build up along with compression in the carpal tunnel. Conservative care is recommended before surgery is recommended. In doing so, this author is investigating the effectiveness of massage therapy for relief of nerve compression to reduce connective tissue fibrosis, edema, or musculoskeletal disturbance. | RESEARCH OBJECTIVE(S): List study objectives. The aim of this study was to evaluate the effectiveness of two distinct massage therapy protocols on strength, function, and symptoms associated with carpal tunnel syndrome (CTS). | Describe how the research objectives address...
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...Factors…………………………………………………..4 2.2 External Factors………………………………………………….5 3.0 Marketing Plan………………………………………………………...5 3.1 Resources…………………………………………………………6 3.2 Objectives…………………………………………………………6 3.3 Marketing Strategy………………………………………………..6 4.0 Target Market……………………………...………………………….7 4.1 Who is Targeted?............................................................................7 5.0 Marketing Mix……………………………….…...……………………8 6.0 SWOT Analysis……………..…………………...……………...……..9 1.0 Executive Summary Under Armour is a high performance clothing line, designed to meet the needs for today’s top athletes. Under Armour is known for its quality and durability, all while providing the customer with different choices regarding fashion trends. Our Mission: To provide the customer with the best possible experience while striving to reach their athletic goals. Under Armour was started in 1996, by a University of Maryland football player, Kevin Plank. Planks initial goal was to create a t-shirt that helped sweat disperse from an athlete’s body, rather than being absorbed by a cotton t-shirt. Since the creation of the compression shirts, Under Armour has expanded their line to compression shorts, thermal wear, outer wear and even footwear. Plank has taken the connections he gained while competing in football and used those associates to financially support the establishment of his business. Now Under Armour has grown into a multimillion dollar company, earning revenue that...
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...WOMEN’S HIGH HEEL DISCOMFORT ANALYSIS AND PROTOTYPE SOLUTION A Senior Project submitted In Partial Fulfillment of the Requirements for the Degree of Bachelor of Science in General Engineering And Bachelor of Science in Industrial Engineering California Polytechnic State University, San Luis Obispo by Kevin Blakley and Annamarie Kepple February 2013 Graded by: ______________ Date of Submission__________________________ Checked by: _____________ Approved by: _____________________________ Page 1 of 76 ABSTRACT WOMEN’S HIGH HEEL DISCOMFORT ANALYSIS AND SOLUTION Kevin Blakley and Annamarie Kepple Women love high heeled shoes, but this love comes at the cost of comfort. Wearing high heels causes a lot of pain and, in the long term, health complications. This project tries to overcome the problem by ultimately making high heels more comfortable. In order to do this, one must first understand the reasons that high heels are uncomfortable, such as arch angle, heel height, and the changes in walking motion. Once there is a true understanding of the factors that contribute to high heel discomfort, the design stage can begin. The design selected for this project was a wedge heel that contained compressive material. This design would improve user comfort in four different criteria. These criteria were arch angle, compression of the shoe, foot rotation, and ground contact surface area of the heel. After the working prototype was created, it was performance...
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...Table of Contents Title Page ………………………………………………………………………………………………………………………….……………..... 1 Table of Contents ………………………………………………………………………………………………………………………………. 2 Case Analysis ……………………………………………………………………………………………………………………………………... 3 Family Life Cycle ………………………………………………………………………………………………………………….… 3 Figure 1: Consumer Development ……………………………………………………………………………………….… 4 Decision Dynamics …………………………………………………………………………………………………………………………..... 4 Children’s Perspective ……………………………………………………………………………………………………………………..... 5 Cell Phone Companies’ Perspective ………………………………………………………………………….……………..………... 6 Figure 2: Two Examples of Cell Phones Designed for Kids...….……………………………………..………... 6 Child Advocates’ Perspective …………………………………………………………………………………………………………….. 8 Parents’ Perspective………………………………………………………………………………………………………………….…….... 8 Figure 3: Survey Questions …….………………………………................................................................. 9 Recommendations …………………………………………………………………………………………………………………………... 10 Figure 4: Teen Cell Phones and Smartphones Ownership …………………………………..……………….. 11 References ……………………………………………………………………………………….………………..……..…………………….. 14 Appendix …...……………………………………………………………………………………………………………….…….…………….. 16 Case Analysis Children: The Final Frontier . . . For Cell Phones It is difficult to exist in today’s society without being influenced by the dramatic increase of the technology use and especially the use of cell phones. The cell phone market is becoming...
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...has come up with a new product and marketing strategy aimed at finding ways to capture the woman’s sport apparel market after years of failed attempts (Warner, 2005). After interviewing different women, Nike found that most women want a sports outfit that has cross-functional uses. One consumer stated that she wants a nice outfit that’s suitable for hanging out with friends, wearing it to work, or simply to workout in (Warner, 2005). Hence, the company has started mailing out their new female apparel catalog called Nikewomen. Nike also launched the Nikewomen.com website which features the apparel as well as highlighting new workout trends (Warner, 2005). Under Armour also launched a clothing line for women making sports bras and compression shorts. However, that marketing strategy failed in...
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...Under Armour Andrea George Alvernia University Abstract Under Armour is a North American sports apparel company started in 1995. Started by Kevin Plank, his business has become one of the leading companies in the sports apparel industry. Under Armour is best known for its moisture wicking t-shirts. Under Armour is popular among middle and upper class athletic and health conscience consumers. It competes with other popular sports footwear and apparel companies. Nike and Adidas are Under Armour largest competitors. Under Armour offers a variety of clothing, sports equipment and footwear. They will continue to be a very competitive company in the sportswear market. History of the company Under Armour was started by Kevin Plank in 1995. He was a special teams captain on the University of Maryland football team. During games his teammates’ cotton shirts would be soaked with sweat and heavy to wear. Realizing there could be a better option, Kevin began looking and researching ways to produce a better type of t-shirt. After Kevin graduated from college he began working on a superior t-shirt. He used fabric samples to build his first prototype. He gave this prototype to his Maryland teammates to get feedback on how the shirts performed. From their feedback he found that using microfibers in the t-shirts wicked away moisture that helped keep athletes dry and cool while participating in sports. Kevin ran his business out of his grandmother’s basement working...
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...UNIVERSITY OF ECONOMICS HO CHI MINH CITY International School of Business ------------------------------ Bui Trung Kien FACTORS AFFECTING THE FLUCTUATION OF LABOUR PRODUCTIVITY IN THE CONSTRUCTION PROJECTS MASTER OF BUSINESS (Honours) Ho Chi Minh City - 2012 UNIVERSITY OF ECONOMICS HO CHI MINH CITY International School of Business ------------------------------ Bui Trung Kien FACTORS AFFECTING THE FLUCTUATION OF LABOUR PRODUCTIVITY IN THE CONSTRUCTION PROJECTS ID: 60340102 MASTER OF BUSINESS (Honours) SUPERVISOR: Dr. CAO HAO THI Ho Chi Minh City - 2012 i ACKNOWLEDGMETS Firstly, I would like to express my deepest appreciation to my supervisor Dr. Cao Hao Thi for his professional guidance, valuable advice, continuous encouragement, and motivated support that made this thesis possible. I would like to extend deep senses of gratitude to Prof. Nguyen Dinh Tho and lecturers who have taught and transferred me valuable knowledge and experience during the period of Master of Business course at International School of Business. Special thanks, to all of my dear friends in MBUS 2010 class, who gave me useful material, response and experience to conducting this study. I would like to express my grateful thanks to my friends and all the construction company in Vietnam who participated in filling the questionnaires and provided the valuable information for this study. Personally, I wish to express my deep gratitude to my parents, my wife...
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...VACUUMING INTRODUCTION Vacuuming: nearly everyone is doing it! Unlike jumping a horse or throwing a curve-ball, vacuuming does not discriminate or limit itself to highly trained individuals or athletes. A vacuum cleaner, or commonly known as a vacuum, is typically an electric device that by means of suction collects dirt and small particles from a variety of surfaces. All it functionally requires is electricity, a vacuum cleaner appliance and a willing and able individual. This common invention is everywhere; household closets, hotels, general workplaces, restaurants and just about any other place that has carpeting or accumulates dust. 700 B.C. was the first noted appearance of woven forms of floor coverings and one could debate that primitive cleaning methods were developed thereafter (carpetandrugpedia.com). A cleaning method other than the traditional “carpet beater” was born in the mid-1800s. This time is known as the industrial revolution and was a critical in the invention of the vacuum cleaner. Factories were producing thousands of manufactured items and with it came an overwhelming amount of dust, soot and industrial pollution. This was also during the same time that infectious disease was being linked to germs. The need for hygiene and cleanliness was born and gave birth to the idea of the vacuum cleaner. By a patent issue date in 1860, Daniel Hess appears to have invented the first device to have the some of the basic principles of the modern vacuum. The...
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...it enjoy an almost monopolistic presence especially in the developing nations of the world. On the other hand, the market structure can be seen as an oligopoly. This is due to the fact that there are other key players like GM who are peer competitors. Toyota is keen to see what these competitors are doing and make sure it reacts to their actions in a way that will guarantee its market leadership. 2.0 Situation Analysis Toyota’s capacity to stay on top of productivity efficiency and quality rankings can be credited to its internal environment. This entails the way production process is managed by the top management who are famous for their competency. The production team has an insatiable obsession to improve the efficiency and effectiveness of its manufacturing operations. Therefore, to fully understand the situation analysis of Toyota Company, a SWOT analysis is determined and it mainly consists of the Company’s strengths, weaknesses, available opportunities, and finally the threats that the Company is experiencing or projected to go through. 2.1 SWOT Analysis Strengths and weaknesses are referred to as internal factors of the Company as their impact starts from within the Company, while opportunities and threats normally originates from...
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...Case Study Analysis: Uterine Fibroids Victoria Moss COMM/215 5/14/12 David Mumford Case Study Analysis: Uterine Fibroids Uterine fibroids develops in the muscular wall in the uterus are not malignant tumors or growth. Fibroids are found in women and are a type of growth not cancer. It is common in women who are between the ages of 25-45. Uterine fibroids are also called leionyomas or myomas. Fibroids do not cause problems when they remain small. They can grow inside and outside the uterus. Once the fibroids grow larger in size they can cause complications. Sometimes fibroids have grown large enough to fill the whole abdomen. In African American women uterine fibroids exist more than in White women. Researching upon uterine fibroids it is not understood the causes and fibroids grow quicker in African American women. The female hormones estrogen and progesterone can increase or decrease throughout women's life. When a woman goes through menopause it decreases estrogen. When going through menopause fibroids tend to shrink. Birth control pills can cause fibroids to grow because it is a hormonal drug that contains estrogen. Fibroids may cause some of these symptoms like changes in menstruation, heavy periods, and cramps. Vaginal bleeding other than menstrual cycle can cause anemia. Causes pain in the abdomen or lower back. It may inquire pain while acquiring sex or pressure when urinating. The uterus is enlarged, miscarriages, and infertility are other symptoms. When...
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...The Global Pharmaceutical Industry Case Analysis This case by Sarah Holland and Bernardo Bátiz-Lazostudies studies the evolution of the ethical pharmaceutical industry and analyses the various forces affecting the discovery, development, production, distribution and marketing of prescription drugs. The authors further analyses the critical issues of corporate social responsibility in the industry and the strategies being followed by major pharmaceutical companies and the challenges and opportunities for the future. This case bases its research to find evidence to support or disprove findings of a report published in the Gardiner by analysts at the investment bank of Dresdner Kleinwort Wasserstein which claimed that the world's major drugs companies are operating a business model that is unsustainable and rapidly running out of steam. On the surface however, the pharmaceuticals business seems like the epitome of a modern, mature industry that has found a comfortable way to make profits by the billion. According to the case large pharmaceuticals companies are currently facing the most challenging times since a decade. Even though the industry has made tremendous contributions to human well-being, its roles and actions are still criticized by the media and under constant scrutiny by national governments in their efforts to reduce expenditure in healthcare. Stringent laws and regulations have come in action which has made product approval, pricing and promotions costlier...
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...which are embedded in an inert excipients matrix designed to overcome the difficulties in administering capsules and improved physico-chemical stability compared to suspensions. The functional coating like drug coating, barrier coating, enteric polymer coating is usually applied in a fluid bed coating processor provides each subunit with the characteristic desired drug release properties. The size, shape and surface morphology of the pellets to be coated are the prerequisites for coating of pellets. Design of MUPS involves formulating pellets by different techniques and further compression of these pellets into rapidly disintegrating tablets; disintegrate rapidly in the oral cavity for the delivery of coated pellets into the gastrointestinal tract or the site of release of the drug. In spite of the challenges like content uniformity of the compressed tablets, ability of the film to withstand compression force. MUPS occupy a prominent role in formulating drugs due to their greater patient compliance, process, formulation and therapeutic advantages. A design principle of increasing importance for sustained, controlled, delayed, site specific or pulsatile release preparations is the compaction of coated particles into disintegrating multiple unit tablets. One challenge in the production of disintegrating multiple unit tablets is maintaining the modified drug release after compaction, as the application of the compaction pressure can...
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...THE ART OF CYBER WAR — ASYMMETRIC PAYOFFS LEAD TO MORE SPENDING ON PROTECTION 151 As Physical Security Converges With IT Security and Becomes More Network-Based, Can Cisco Compete? Cisco recently introduced new video surveillance IP cameras and monitoring software targeted for small businesses. As corporate security technology and services become increasingly network-delivered and database-driven, the physical security market presents a compelling incremental growth opportunity for Cisco that we believe can exceed the billion dollar annual revenue threshold in the next 35 years. The physical security industry has been undergoing a paradigm shift toward convergence, whereby previously disjointed functions of IT security and physical security are experiencing greater formal cooperation. Organizations continue to implement more IP-based video surveillance cameras and building access controls both to upgrade capabilities and to reduce operational costs. Deploying IP-based security upgrades capabilities and reduces operational costs. Through the IP network a security system can assign priority to data and automatically discover new nodes such as IP cameras and control sensors, eliminating the time and effort of manual provisioning. Shifting building access controls from isolated networks to existing IP networks that house data, voice, and video can improve incident detection and assessment, authenticating both the user and device to provide efficient integrity checks. • Video...
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...Decision Support System SYNOPSIS DSS Development 1. General idea of design and development process approaches: a. Traditional systems analysis and design, SDLC approach. b. An iterative, speedy prototyping c. Managers can develop their own personal DSS 2. Investigate alternative designs along with the development process approaches a. Building effective DSS is important matter b. Choose an approach that increases the chances of benefits of DSS c. Building a DSS is a difficult task since different employees have different job responsibilities and take different decisions. 3. Decision oriented Design Approach a. Pre design description and diagnosis of decision making functions b. Diagnosis of current decision making is to be prepared c. Determine how decisions are currently made 4. Decision orientation is the key a. Specify changes in decision process b. Flow chart the process c. Specify what specific improvements in the decision performance are to be made 5. Diagnostic Steps a. Collect data on present decision making b. Use interviews, observations or pervious records. c. Establish a logical description of the same d. Specify a norm as to how a decision should be made 6. Decision process audit plan a. What will be audited and by whom? b. Examine and diagram the process? c. Observe and collect data? d. Evaluate performance e. Reporting and recommendations are done accordingly 1 Decision Support System 7. Reaching a diagnosis a. Focus on identifying...
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