One of the major environmental impacts the production of technetium-99m can have is from a meltdown of a nuclear reactor. Even though this is a very rare occurrence in history, the damage the meltdown of a reactor can produce is catastrophic and needs to be taken seriously. When a nuclear reactor does not have a viable source to cool it down during nuclear fission, nuclear meltdown will occur. From this nuclear meltdown, major catastrophic events can occur. Radiation leakage from the plant into the surrounding area from these meltdowns can cause extreme Biological and Ecological Impacts. Cancer Induction, Genetic Damage to Future Generations and Apoptosis are three of the most extreme reactions that high amounts of radiation can cause on humans